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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7544712 |
Treatment of coronavirus infection
A method for treating coronavirus infection by administering to a subject in need of the treatment an effective amount of one or more of the following compounds: aklavin, sanguinarine, amiodarone,...
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7329689 |
Monohydrate hydrochloride of the 4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylaminomethyl-naphtalen-2-yl) ester
A compound having formula (I) and a process for the preparation thereof are described.
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7138122 |
Therapeutic systems
A compound comprising a target cell-specific portion and human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity...
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7045512 |
Fungicidal phenoxyphenylhydrazine derivatives
A fungicidally active compound of the formula:
a)
wherein
Q is —NY—NH—, —N═N—, or
X is oxygen, sulfur, sulfoxide, or sulfone; n is 0 or 1; Y is hydrogen, C 1 –C 4 ...
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6867231 |
Therapeutic systems
A compound comprising a target cell-specific portion and human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity...
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6825224 |
Prodrugs of carbamate inhibitors of IMPDH
The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6753298 |
Agents for combating Neospora spec
Compositions for controlling diseases caused by protozoans of the genus Neospora, which are characterized in that they comprise one or more active compounds which inhibit the microtubulin system of...
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6716875 |
Synergistic therapeutic compositions of ACE and renin inhibitors and methods
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
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6696488 |
(Hydroxyethyl)ureas as inhibitors of alzheimer's β-amyloid production
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein...
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6686391 |
N-chlorophenylcarbamate and N-chlorophenylthiocarbamate compositions
Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof....
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6589986 |
Methods of treating anxiety disorders
This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula: wherein: R 1 is H, alkyl,...
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6534546 |
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
Compounds represented by the general formula (1): (where R 1 is SR 6 or NR 7 R 8 , where R 6 is typically an alkyl group having 1-6 carbon atoms, R 7 is a hydrogen atom, an alkyl group...
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6498188 |
Methods of treatment for cancer or viral infections
Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof....
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6458781 |
Substituted diarylalkyl amides as calcium channel antagonists
The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I...
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6416789 |
Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage
A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be...
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6375999 |
Methods for treating potatoes
A sprout inhibitor for potatoes is introduced into a potato storage facility as a gas phase carried in an air stream. The liquid sprout inhibitor may be heated prior to injection into a flowing air...
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6297275 |
Method for controlling fungi using phenylhydrazine derivatives
A method for controlling fungi using a phenylhydrazine derivative compound of the formula: ##STR1## wherein: X is phenyl, phenylalkoxy, phenoxy, or benzyl, alone or in combination with one or...
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6274586 |
Combatting parasitic fungi with a combination of an active agent inhibiting respiration in the cytochrome complex III and of fenazaquine
The present nvention relates to compositions for controlling harmful fungi which comprise, as active ingredients, at least one compound which inhibits respiration on the cytochrome complex III and...
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6232339 |
Phenylcarbamates, their preparation, and compositions comprising them
Phenylcarbamates of the formula I ##STR1## where: R 1 is C 1 -C 4 -alkyl; R 2 is cyano, nitro, trifluoromethyl, halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy; m is 0, 1 or 2,...
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6197805 |
Broad spectrum antimicrobial mixtures
This invention is directed to a broad spectrum antimicrobial composition which comprises a mixture of an iodopropynyl compound in combination with 2-(methoxycarbonylamino)benzimidazole and, where...
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6177460 |
Method of treatment for cancer or viral infections
Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof....
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6172108 |
Hydrazide compounds
Compounds of formula (I): R--NH--A--CO--NH--NH--(W) n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O) r wherein r is 0, 1 or 2, Z represents a group selected from aryl,...
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6117900 |
Use of retigabine for the treatment of neuropathic pain
The invention relates to the use of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene
of formula I ##STR1## or its pharmaceutically utilizable salts, for the prophylaxis and treatment...
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6060484 |
Anti-viral method
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6043284 |
Anti-atherosclerotic diaryl compounds
The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT...
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6040339 |
Urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use
Compounds of formula (I): ##STR1## wherein: R 1 is alkyl; R 2a , R 2b , R 2c and R 2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic...
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5994398 |
Arylsulfonamides as phospholipase A.sub.2 inhibitors
Arylsulfonamides which have the general structure: with the symbols R 1 , R 2 , R 3 , R 4 , A and n representing the groups and integers provided in the detailed description are provided herein....
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5962511 |
Drugs for allergic and eosinophilic diseases
A method of inhibiting human IL-5 gene transcriptions mRNA expression and protein production by human T-cells using one or more compounds selected from those shown by formula I shown below (where R...
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5942541 |
Substituted amino acid amide derivatives their preparation and use as fungicides
There are described new amino acid amide derivatives, some of which are known, of the formula (I) ##STR1## in which R 1 to R 8 have the meaning given in the description, and a process for their...
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5886046 |
Dicarbonyl-containing compounds
This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other...
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5874465 |
Hydrazinecarboxylate miticides and insecticides
Compounds having the structural formula: ##STR1## wherein: R is C 1 -C 6 hydroxyalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 7 -C 9 aralkyl, or nitroso; R' is C 1 -C 4 alkyl; and R" is C...
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5852053 |
Use of 2-4-amino-4-(4-fluorobenzylamino) (-1-ethoxy-carbonylaminobenzene for the prophylaxis and treatment of the neurodegenerative disorders
The use of the compound I ##STR1## or its pharmaceutically utilizable salts for the propylaxis and treatment of the squelae of chronic reduced cerebral blood supply, in particular of stroke, and...
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5849789 |
Use of 4-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene for the prophylaxis and treatment of reduced cerebral blood supply
The use of the compound I ##STR1## or its pharmaceutically utilizable salts for the propylaxis and treatment of the sequel of chronic reduced cerebral blood supply, in particular of stroke, and for...
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5830854 |
Method of treating cystic fibrosis using a tachykinin receptor antagonist
Tachykinin receptor antagonists are useful for the treatment of cystic fibrosis.
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5773465 |
Tartronic acids, their acetalic ethers and o-esters
Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C 2 -C 12 ...
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5733935 |
Hydroxylamine derivatives and fungicides containing the same
A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R 1 and R 2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group,...
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5709890 |
Polyaspartic acid and its analogues in combination with insecticides
An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small...
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5658945 |
Urethanes and ureas that induce cytokine production
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or...
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5616612 |
Urethanes and ureas that enhance the growth of bone marrow progenitor cells
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or...
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5545640 |
Protease inhibiting succinic acid derivatives
Disclosed herein are compounds which inhibit human immunodeficiency virus (HIV) protease activity and inhibit HIV replication in human cells. Thus, the compounds are indicated for the treatment of...
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5459149 |
Penta-2,4-dienamides and use as pesticides
The present Application discloses pesticidally active compounds of formula (I): Q(CH 2 ) a (O) b Q 1 CR 2 =CR 3 CR 4 =CR 5 CXNR 1 R x or a salt or propesticide thereof, wherein Q is an...
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5436267 |
N-phenylcarbamate compound, process for preparing the sasme and biocidal composition for control of harmful organisms
A novel N-phenylcarbamate compound or its salt where possible, which is useful as the active ingredient of a biocidal composition for control of harmful organisms, is represented by the following...
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5393776 |
Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for...
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5384328 |
Oxysulfonyl carbamates
The present invention is directed to compounds of the following general Formula I, methods for using the compounds of Formula I, pharmaceutical compositions thereof, and processes for preparing the...
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5356931 |
Use of α-arylacrylic derivatives for controlling pests
Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1; m is 0, 1, 2, 3 or 4; R 1 is cyano, cyanato, thiocyanato, nitro,...
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5344845 |
Compound and use of the same as medicine
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate,
or a pharmaceutically acceptable salt thereof. These compounds...
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5268389 |
Thiocarboxylate ester compounds compositions containing the same
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such...
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5151443 |
Method of controlling termites
A method of controlling termites employing substituted phenoxy, phenylthio and anilino compounds.
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