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7579373 |
Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or...
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7495028 |
R-bambuterol, its preparation and therapeutic uses
R-enantiomer of Bambuterol, its preparation and therapeutic uses are disclosed. A composition includes R-Bambuterol or its therapeutically acceptable salt. A composition of R-Bambuterol includes at...
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7488757 |
Invisible antimicrobial glove and hand antiseptic
An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual,...
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7368478 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula:
wherein G 1 and G 2 are each independently...
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7235585 |
Enzyme activated self-immolative n-substituted nitrogen mustard prodrugs
This invention pertains to certain enzyme (CPG2) activated self-immolative nitrogen mustard prodrugs, which are useful in enzyme prodrug therapy (EPT), such as ADEPT and GDEPT, for the treatment of...
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7122576 |
Carbamate compounds for use in preventing or treating bipolar disorder
This invention is directed to a method for preventing or treating bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of...
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7115660 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula (I): wherein G 1 and G 2 are each independently...
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7087643 |
Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a...
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7078436 |
Carbamate compounds for use in preventing or treating anxiety disorders
This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected...
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7056919 |
Synergistic combination of fungicides to protect wood and wood-based products and wood treated by such combination as well as methods of making the same
A wood treatment composition having a synergistic combination of fungicides which may include two or more compounds. These combinations are shown to be especially effective in providing resistance...
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6838482 |
Fungicidal composition
The present invention provides a fungicidal composition characterized by containing as active ingredients (a) a compound represented by the formula I:
(wherein Ar is a substituted or...
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6815464 |
Carbamate compounds for use in the treatment of pain
This invention is directed to a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6599935 |
Felbamate derived compounds
The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate...
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6589985 |
Carbamate compounds for use in preventing or treating movement disorders
This invention is directed to a method for preventing or treating movement disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected...
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6586466 |
Carbohydrazide-protease inhibitors
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or...
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6548540 |
Method of treating cancer using dithiocarbamate derivatives
Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by...
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6545027 |
Methods of modulating NF-kB transcription factor
A method of modulating NF-kB transcription factor comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R 1 and R 3 are independently...
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6541513 |
Carbamate compounds for use in preventing or treating psychotic disorders
This invention is directed to a method for preventing or treating psychotic disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected...
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6515019 |
Methods of providing symptomatic and prophylactic treatment for medical and neurological conditions
Methods are disclosed for prophylactically and chronically preventing symptomatic depression, neuronal cell injury and cell death in systemic and neurological conditions, populations with...
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6436421 |
Pesticide compositions
The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method...
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6416789 |
Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage
A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be...
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6331542 |
Protease inhibitors
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or...
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6319949 |
Pesticidal sprays
A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant...
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6290992 |
Foam formulation for termite control and method of application therefor
A method of termite control consists of injecting a foam formulation above ground into the walls of a structure infested with termites or other undesirable pests. The inner spaces of affected walls...
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6288110 |
Pharmaceutical compositions comprising disulfiram
Disulfiram (tetraethylthiuram disulfide) is shown to inhibit angiogenesis and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and to prevent cell...
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6225345 |
Azahexane derivatives as substrate isosters of retroviral asparate proteases
The invention relates to compounds of formula (I): ##STR1## wherein R 1 and R 10 are each independently of the other lower alkoxycarbonyl; either R 2 , R 3 and R 4 are each independently of the...
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6177067 |
Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof
Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula: ##STR1## wherein R 1 and R 2 are each independently a C 1 -30 hydrocarbon group...
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6127412 |
Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
The optically pure forms of monocarbamates of halogenated 2-phenyl-1,2-ethanediol and dicarbamates of 2-phenyl-1,2-ethanediol have been found to be effective in the treatment of disorders of the...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6066656 |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition...
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6034123 |
Method for altering blood lipid levels
Use of bambuterol or a pharmaceutically acceptable salt thereof for the manufacture of a pharmaceutical preparation with lipid lowering effect.
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6034117 |
Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method
This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl...
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6005002 |
Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production
The invention provides compounds of formula (I) and (II) wherein X and Y are independently chlorine, bromine, iodine, a mesyl group CH 3 SO 3 or a tosyl group OSO 2 phenyl (wherein phenyl is...
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5973000 |
Hair revitalization tonic composition containing a lipid derivative and use thereof
The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and...
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5942540 |
Methods of providing symptomatic and prophylactic neuroprotection
Methods are disclosed for prophylactically and chronically preventing symptomatic depression, neuronal cell injury and cell death in systemic and neurological conditions, populations with...
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5773469 |
Diaryl antimicrobial agents
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing...
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5763364 |
Thixotropic aqueous plant protection agent suspensions
The invention relates to thixotropic aqueous suspension concentrates of plant protection agents. The invention furthermore relates to the use of these agents in plant protection and the use of...
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5728728 |
Methods of providing neuroprotection
Novel methods are disclosed for treating acute and chronic neurological disease and attenuating further neuronal cell death in neurological diseases, employing a glycine site antagonist at the NMDA...
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5709890 |
Polyaspartic acid and its analogues in combination with insecticides
An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small...
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5656660 |
Compositions and methods for treating mast-cell mediated conditions
The present invention describes compounds, methods and compositions effective to treat mast cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The...
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5462966 |
Methods for the prevention and control of cellular damage resulting from coronary artery occlusion-reperfusion
Methods for protecting warm-blooded animals against the formation of myocardial infarct through the administration of 2-phenyl-1,3-propanediol dicarbamate are disclosed.
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5389674 |
Fungicidal compositions and methods for production thereof
Novel and improved fungicidal dithiocarbamate particulate compositions comprising one or more components selected from dithiocarbamates and bisdithiocarbamoyl disulfides and an effective amount of...
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5373021 |
Use of disulfiram for Neuronal Protection
This invention discloses a rapid-diffusion injectable formulation, comprising disulfiram or a suitable salt or analog of disulfiram. Unlike slow-release injectable formulations designed to ensure...
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5356931 |
Use of α-arylacrylic derivatives for controlling pests
Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1; m is 0, 1, 2, 3 or 4; R 1 is cyano, cyanato, thiocyanato, nitro,...
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5294430 |
Use of dithiocarbamates to treat myelosuppression
A process for preventing or ameliorating the myelosuppression which can occur in a mammal such as a human cancer patient being treated with a platinum-free antineoplastic drug is provided,...
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5290808 |
Method to control the intake of food
Novel methods and compositions for the suppression of the desire for food consumption in warm-blooded animals consisting essentially of the administration of 2-phenyl-1,3-propanediol dicarbamate...
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5256690 |
Method for treating and controlling the symptoms of neurodegenerative disease and neuropsychopharmacological disorders
A method for treating and controlling the symptoms of neuropsychopharmacological disorders and neurodegenerative diseases associated with or resulting from excessive activation of the...
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5208236 |
N-(acylaminomethyl)glutaryl amino acids and use
Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: R 1 and R 3 are independently hydroxy, lower...
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5206264 |
Use of disulfiram to prevent cardiovascular damage
A method is disclosed for reducing cardiovascular damage caused by hypoxic or ischemic events such as heart attack and cardiac arrest. This method involves the administration of disulfiram, or a...
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