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7560483 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof  
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
RE39616 Aminoindan derivatives  
This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R 1 is hydrogen C 1-4 ...
7060727 Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof  
The present invention relates generally to prodrugs of fused GABA analogs, pharmaceutical compositions of prodrugs of fused GABA analogs, methods of making prodrugs of fused GABA analogs and...
6469056 Pharmaceutically active compounds, their preparation and use as ECE-inhibitors  
Pharmaceutically active compounds are prepared as described and used to produce pharmaceutical preparations for treating diseases.
6416789 Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage  
A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be...
6410574 Fungicidal composition and method for using the same  
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
6303569 Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents  
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: ##STR1## wherein: B is H, OH, OSiR 13 , a...
6290992 Foam formulation for termite control and method of application therefor  
A method of termite control consists of injecting a foam formulation above ground into the walls of a structure infested with termites or other undesirable pests. The inner spaces of affected walls...
6239175 Carbamoyloxy derivatives of mutiline and their use as antibacterials  
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R 1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is...
6180095 Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents  
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L 1 is a bifunctional...
6080784 Protein kinase C modulators N  
Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.
5981564 Water-soluble derivatives of paclitaxel, method for producing same and uses thereof  
The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol...
5922761 Methods for in vivo reduction of iron levels and compositions useful therefor  
In accordance with the present invention, there are provided methods for the in vivo reduction of free iron ion levels in a mammalian subject. The present invention employs a scavenging approach...
5773469 Diaryl antimicrobial agents  
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing...
5733924 DC 107 derivatives and treatment methods  
DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, wherein R 1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl,...
5709890 Polyaspartic acid and its analogues in combination with insecticides  
An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small...
5688817 Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics  
Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a...
5519043 Fluorenyl derivatives  
The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one...
5504109 Susbstituted amino acid amide derivatives their preparation and use  
Amino-acid derivatives of the formula ##STR1## in which R 1 represents alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cycloalkyl, cycloalkenyl, unsubstituted or...
5472973 Fluorenyl derivatives as anti-inflammatory agents  
The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one...
5385917 Carboxylic acid derivatives  
Carboxylic acid derivatives of the formula: ##STR1## are provided, which are useful for treatment of androgen dependent diseases.
5356931 Use of α-arylacrylic derivatives for controlling pests  
Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1; m is 0, 1, 2, 3 or 4; R 1 is cyano, cyanato, thiocyanato, nitro,...
5290774 Photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom  
This invention relates to a photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom. The stabilization is attained by adding polyhydric alcohol and boric...
5204370 Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase C  
The present invention provides novel substituted anthraquinones having the formula ##STR1## wherein R 1 and R 2 are independently H, C 1 -C 10 alkyl, aryl, arylalkyl, alkylaryl; n and m are...
5176914 Fungicidal carbocyclic anilide carbamates  
Fungicidal carbocyclic anilide carbamates of the formula ##STR1## in which X represents optionally alkyl-substituted cycloalkyl or optionally alkyl-substituted cycloalkenyl, Hal represents...
5140044 UCN-1028D derivatives  
A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.
5130306 5-Oxygenated HMG-COA reductase inhibitors  
Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) or (II): ##STR1## wherein position 5 of the polyhydronaphthyl ring is...
5112868 Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition  
The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical...
5102911 4-Substituted HMG-CoA reductase inhibitors  
HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##
5010104 Tricyclic compounds  
Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and...
5007790 Sustained-release oral drug dosage form  
Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which...
4971994 Thioureas  
Novel N-phenyl-N-carbonylthioureas of the formula I ##STR1## in which R 1 is C 1 -C 10 alkyl, phenyl-C 1 -C 7 alkyl; C 1 -C 10 alkyl or phenyl-C 1 -C 7 alkyl each of which is...
4946863 CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith  
The present invention relates to 3-aminomethyl derivatives of indane, dihydrobenzofurane, dihydrobenzothiophene, and indoline, acid addition salts thereof, isomers thereof, methods of preparation,...
4760061 Ether and ester derivatives of phenols  
Mono- or bis-complex esters or ethers of a phenol derivative of the formula NU--A--X--R 1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl;...
4693750 Direct tabletting agent  
The present invention provides a direct tabletting agent, consisting essentially of lactose and cellulose with a ratio of lactose to cellulose, referred to the weight, of from 95 to 40:5 to 60, the...
4686233 Pesticidal water-soluble aminoacid sulfenylated carbamates  
Pesticidal water-soluble aminoacid sulfenylated carbamates useful as broad spectrum insecticides and miticides, particularly useful as systemic insecticides.
4618623 Carbazic acid derivatives, process for their preparation and compositions containing the same  
The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds...
4602033 Combating pests with aryl N-oxalyl-N-methylcarbamates  
Aryl N-oxalyl-N-methyl-carbamates of the general formula ##STR1## in which X represents an alkoxy, alkenoxy, alkinoxy, aryloxy, alkylthio, alkenylthio, alkinylthio or arylthio radical, each of...
RE32145 Orally active tolciclate .[.(and tolnaftate).].  
It has been found that fungal diseases can be effectively treated systemically by oral administration of tolciclate or tolnaftate . The drugs drug will generally be administered in divided...
4570002 Carbazic acid derivatives  
The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds...
4551472 Unsymmetrical bis-carbamate compounds  
Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.
4551461 Soft contact lens ambient temperature disinfectant and rinsing solution and method  
Aqueous compositions for the ambient temperature or cold disinfection of soft contact lenses during non-wearing periods is provided. The composition includes water and a disinfectant composition...
4543362 P-Alkyl or cycloalkyl phenoxy alkanols and alkanol esters and process for the treatment of allergic conditions  
p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R 1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still...
4533675 Carbamates of colchicine for treatment of gout  
The present invention consists of derivatives of colchicine and thiocolchicine which are carbamates of the same and are illustrated by the formula below: ##STR1## where either X 1 or X 2 is a...
4505905 Cyclobutanone antibacterials  
Certain 7-oxobicyclo[3.2.0] hept-2-en-2-carboxylic acids, esters, and salts thereof useful as antibacterial agents or as intermediates for antibacterial agents, and methods for making and using them.
4486447 Pesticidal symmetrical bis-sulfenylated-bis carbamate compounds  
Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.
4426385 Insecticidal bicyclooxyphenyl ureas  
Novel bicyclooxyphenyl ureas, such as 1-(bicyclooxyphenyl)-benzoyl ureas, are provided which exhibit pesticidal activity. The compositions are conveniently prepared by reacting an isocyanate with...
4410519 Tetraline derivatives, their production and pharmaceutical compositions containing them  
An optically active or racemic 2-amino-5-hydroxy-1,2,3,4-tetrahydronaphthalene wherein the nitrogen atom of the amino group carrier two alkyl groups, one of which is unsubstituted and the other is...
4389417 Treatment of gray matter edema  
The invention relates to the treatment of gray matter edema in the brain or spinal chord by the administration of (indanyloxy)acetic acids, and analogs and salts thereof.
4348407 Orally active tolciclate and tolnaftate  
It has been found that fungal diseases can be effectively treated systemically by oral administration of tolciclate or tolnaftate. The drugs will generally be administered in divided daily doses in...
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