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7084128 |
Method for reducing intraocular pressure
The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a...
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7081449 |
Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′...
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7071173 |
Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine
A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig
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7056894 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof
The present invention provides compounds having the formula:
wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are...
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7053064 |
Compounds for the treatment of tobacco dependence and withdrawal
The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or...
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7049303 |
Inhibition of viruses
Disclosed is a pharmaceutical composition comprising a ribonucleoside analogue in accordance with general formula I or II as herein defined, in admixture with a physiologically acceptable excipient...
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7045309 |
9-substituted adenine derivatives as prodrug regulators of cell and tissue function
The present invention relates to 9-substituted adenine derivatives represented by formula (I)
wherein W is selected from the group consisting of H, halogen, azido and amino group; X is...
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7030100 |
Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of...
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7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
The present invention provides compounds having the formula:
wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted...
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7018985 |
Composition and method for inhibiting platelet aggregation
The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method...
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6995145 |
Methods and compositions for modulating drug activity through telomere damage
The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in...
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6987095 |
Fish feed with increased nucleotide content
The present invention provides for the improved uptake of feed additives, pigments for use in coloring the flesh and the like. This improved intestinal uptake of foodstuffs and additives is...
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6977246 |
Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y 2 and/or P2Y 4 purinergic receptor. They are useful in the...
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6974802 |
Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine
A method of treating HBV or HIV infections comprising administering to an individual an effective amount of the compound of formula IId′:
wherein R 2 is the residue of an aliphatic...
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6958324 |
Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount...
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6949522 |
β-2′- or 3′-halonucleosides
The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or...
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6919320 |
Pharmaceutical compositions containing deoxyribonucleosides for wound healing
The invention relates to compositions comprising 2′-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial...
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6897201 |
Compositions and methods for the treatment of glaucoma or ocular hypertension
The present invention is directed to a method of reducing intraocular pressure. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a...
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6858591 |
Antibiotic AA 896 analogs
The invention provides compounds of the Formula 1
wherein the definitions of m, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are in the specification....
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6838447 |
Particulate compositions for chemical synthesis
Disclosed are compositions that include triboelectrically chargeable nucleotide particles of less than 50 μm diameter and carrier particles. In one example, a substrate is selectively patterned...
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6833361 |
Nucleosides having bicyclic sugar moiety
Conformationally restricted 2′, 4′-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or linking...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6800616 |
Treatment of HIV infections
Disclosed is a method of treating an HIV-infected host including administering to the host a therapeutic agent that is cytotoxic or cytostatic with respect to CD4+ T cells, but has reduced...
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6787526 |
Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described...
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6784161 |
Method for the treatment or prevention of flavivirus infections using nucleoside analogues
The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount...
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6762170 |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
There are provided according to the invention, novel compounds of formula (I) wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations...
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6703376 |
Use of uridine triphosphates and related compounds for the prevention and treatment of pneumonia in immobilized patients
A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises...
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6689759 |
Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6680303 |
3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6677310 |
Ring-expanded nucleosides and nucleotides
The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded (“fat”) heterocyclic ring, in place of purine, and an unmodified or modified...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6660723 |
Phosphalohydrins and methods for medicinal administration
The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH 3 and —CH...
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6660721 |
Anti-HCV nucleoside derivatives
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known...
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6624203 |
Nucleic acid bases used in ophthalmic solutions
An ophthalmic solutions that are broad ranged and effective in low concentrations relative to state of the art systems. In particular it has been found that ophthalmic solutions comprising 0.00001...
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6620796 |
Combinatorial library synthesis and pharmaceutically active compounds produced thereby
The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications,...
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6599887 |
Methods of treating viral infections using antiviral liponucleotides
Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral...
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6596700 |
Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described...
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6593306 |
Methods for modulation and inhibition of telomerase
It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
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6569837 |
β-L-2′-deoxy pyrimidine nucleosides for the treatment of hepatitis B
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
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6562801 |
PpGpp and pppGpp as immunomodulatory agents
The present invention relates generally to the fields of immunopreventive therapy and vaccine development. More particularly, it concerns compositions and methods of use of the bacterial...
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RE38090 |
3′-substituted nucleoside derivative
The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents...
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6528042 |
Compositions of flavonoids for use as cytoprotectants and methods of making and using them
Non-naturally-occurring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. These compositions comprise a flavonoid or derivative thereof and...
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6512004 |
Promoters of neural regeneration
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
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6506736 |
Method for obtaining and using a combination of a purine nucleotide and nitrogen monoxide donor for treating sexual dysfunction
A method for treating a human being having or suspected of having sexual dysfunction or a disorder of physiological and/or anatomical response to sexual stimulation, said dysfunction or disorder...
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6495528 |
2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2...
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6475985 |
Nucleosides with antiviral and anticancer activity
The invention provides nucleosides of formulae (I), (II), (V) and (VII) as described in the specification which possess antiviral and anticancer activity. Treatment of breast cancer is a preferred...
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6465441 |
Screening method for modulation of human mast cell activation
Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the...
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6440946 |
Multiple-agents-binding compound, production and use thereof
The present invention is to provide a multiple-agents-binding compound comprising a compound having anti-HIV activity and having no affinity for cell surface protein bound together with a same or...
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6440469 |
Plant protein for nutritional products and method of making same
The present invention relates generally to a method of producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese or nucleotides. More...
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6420347 |
Method of treating ciliary dyskinesia with uridine triphosphates and related compounds
A method of stimulating ciliary beat frequency in a subject in need of such treatment is disclosed. The method comprises administering to the airways, ears, eyes, or genito-urinary tract of the...
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