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7612103 |
Pleuromutilin derivatives as antimicrobials
Compounds of formula
wherein
R 1 and R 1 ′ are hydrogen or deuterium, R 2 , R 3 and R 4 are hydrogen or deuterium, R 5 is the residue of an amino acid, X is S or N-ALK,
is...
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RE40861 |
Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
Compounds of formula (I)
wherein the groups are as defined in the description are disclosed.
The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine...
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7531572 |
Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl...
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7511095 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs...
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7211570 |
Treatment of EBV and KHSV infection
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
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7199081 |
Aqueous compositions for seed treatment
An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight:
a) 2–10% of a...
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7160907 |
Pleuromutilin derivatives
Pleuromutilin compounds of the formula:
are of use in anti-bacterial therapy.
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7087642 |
Inhibitors of IMPDH enzyme
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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7067553 |
Thiourea compounds and the pharmaceutical compositions containing the same
The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid...
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7053150 |
Segmented polymers and their conjugates
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
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7026354 |
Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria
Compositions including an aromatic compound for inhibiting the production of exoproteins by Gram positive bacteria are disclosed. The aromatic inhibitory compounds of the present invention have the...
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6998419 |
3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1...
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6949574 |
(Oxime)carbamoyl fatty acid amide hydrolase inhibitors
The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical...
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6943148 |
Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic...
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6812218 |
Lipid derivatives of polythiourea
The present invention relates to novel compounds which make it possible to transfer nucleic acids into cells. These novel compounds are lipid derivatives of polythiourea. They are useful for the in...
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6774180 |
Synthesis of high molecular weight non-peptidic polymer derivatives
High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the...
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6730700 |
3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1 -R 4...
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6696487 |
Fungicidal phenyl(thio)urea and phenyl(thio)carbamate derivatives
The invention relates to compounds of formula (I), and also to salts thereof, which have fungicidal activities: in which the various radicals and substituents are as defined in the description,...
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6689774 |
Zinc ionophores as therapeutic agents
The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof....
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6677308 |
Meta-substituted phenylene sulphonamide derivatives
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula...
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6673788 |
Electrophilic ketones for the treatment of herpesvirus infections
A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula II: wherein each of R 1 , R 2 , and R 3 is...
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6653309 |
Inhibitors of IMPDH enzyme technical field of the invention
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6630509 |
Phenalkyloxy-phenyl derivatives
The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical...
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6620798 |
Synergistic agents for enhancing tissue repair
Methods for the repair, reconstruction and protection of tissue using compositions containing flavonoids and/or flavonols, including simultaneous administration of agents in order to obtain...
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6573297 |
(2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same
A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C 3-30 expressed by R 1 and the...
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6548540 |
Method of treating cancer using dithiocarbamate derivatives
Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by...
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6524564 |
Urethane(meth)acrylates containing siloxane groups and able to undergo free-radical polymerization
The present invention relates to free-radically polymerizable, siloxane-containing urethane (meth)acrylates which comprise, in incorporated form, a) at least one compound which contains at least...
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6506794 |
Aqueous fungicide dispersion
An aqueous dispersion comprising a halopropargyl compound (HPC) and a partially hydrolysed polyvinyl alcohol (PHPVA). The aqueous dispersions are useful for inhibiting the growth of micro-organisms...
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6500849 |
1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino 1,3-propanediols and related compounds
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and...
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6498188 |
Methods of treatment for cancer or viral infections
Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof....
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6407090 |
Zinc ionophores as anti-apoptotic agents
The present invention provides methods and compositions comprising one or more zinc ionophores for blocking apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and...
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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6331531 |
Method for controlling harmful organisms in crops of useful plants
Method for controlling harmful organisms in genetically modified cotton plants which contain a gene derived from Bacillus thuringiensis which encodes and expresses an insecticidally active protein,...
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6309633 |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently...
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6303649 |
Naphthalene derivatives
##STR1## A compound of formula (I), wherein R 1 is carboxy or protected carboxy, R 2 and R 3 are each independently hydrogen, hydroxy, or protected hydroxy, R 4 is hydrogen or halogen, R 5 is...
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6124349 |
Method for preparation of pharmaceutical-grade dithiocarbamate
The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a...
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6103768 |
Fatty acid based compositions and methods for the control of plant infections and pests
The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination...
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6075023 |
Method for combatting fish mycoses and one-celled ectoparasites
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6030924 |
Solid formulations
The novel solid formulations obtained by low pressure extrusion of a mixture comprising at least one active ingredient; and at least one defoaming agent and/or foam breaking agent from the ...
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6020317 |
Glycerol derivative, device and pharmaceutical composition
The object of the invention is to provide a lipid device functionally equivalent to the so-called cationic liposome and of lesser toxicity and a lipid or the like as a component of the device. The...
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5989597 |
Process for sterilizing soil
A process for continuously and instantaneously sterilizing soil comprising the steps of applying a water-activated chemical fumigant below the surface of the soil which simultaneously applying...
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5973000 |
Hair revitalization tonic composition containing a lipid derivative and use thereof
The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and...
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5922761 |
Methods for in vivo reduction of iron levels and compositions useful therefor
In accordance with the present invention, there are provided methods for the in vivo reduction of free iron ion levels in a mammalian subject. The present invention employs a scavenging approach...
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5858402 |
Methods for in vivo reduction of cyanide levels and compositions useful therefor
In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in...
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5846997 |
Liquid formulations
The present invention relates to water-emulsifiable liquid formulations of insecticidal active compounds, characterized in that they contain a) 2.5 to 30% of active compound, b) 5 to 77.5% of...
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5811456 |
Monoamine oxidase B inhibitors, processes for their preparation and use thereof
Novel monoamine oxidase B inhibitors of formula (I), wherein R 1 H, an optionally substituted benzyloxy or phenylethoxy group; p=0-3; R 3 H, a CN, OH, CCH group, a C 1 -C 3 ...
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5773014 |
Compositions and methods for inhibiting the formation of unwanted skin pigmentation
Compositions for inhibiting the formation of unwanted skin pigmentation combine high tyrosinase blocking capabilities with stability in cosmetic preparations, absence of significant cytotoxic...
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5763480 |
Inhibitors of cell-medicated disorders
The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The...
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5753667 |
1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, their preparation and their therapeutic application
The present invention provides a compound of formula (I) ##STR1## in which R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group, R 2 represents a hydrogen atom or a straight or branched (C...
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