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7579372 |
Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit...
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7557139 |
Triptolide analogs for the treatment of autoimmune and inflammatory disorders
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
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7528168 |
Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases
The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically...
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7524883 |
Eponemycin and epoxomicin analogs and uses thereof
The present invention provides compounds having formula (1): wherein R 1 -R 6 , A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
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7521478 |
Total synthesis of myriaporones
Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each...
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7476650 |
Enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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7411000 |
Process of inhibiting cell death in injured cartilage
Processes for inhibiting apoptotic cell death and glycosaminoglycan release from injured cartilage is provided. Inhibition is accomplished using caspase inhibitors.
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7405194 |
Therapeutic agents and methods of use thereof for the treatment of melanoma
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis...
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7351739 |
Bioactive compounds and methods of uses thereof
In one aspect, the present invention provides compounds having formula I or IV as shown below:
as further defined herein. In additional aspects, the present invention provides compositions and...
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7348307 |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one...
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7345046 |
Heteroaryl-fused pyrimidinyl compounds as anticancer agents
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the...
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7332523 |
TNP-470 polymer conjugates and use thereof
The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470...
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7312237 |
Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders.
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7250157 |
Dermatological compositions and methods
Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin...
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7229979 |
Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents
Methods of treating a host suffering from restenosis are provided. The methods include delivery of a stent coated with a hypoestoxide, hypoestoxide derivative or hypoestoxide agonist compound to a...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7157420 |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by...
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7144917 |
Inhibitors of matrix metalloproteinases
The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune...
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7129271 |
Compounds for pest control and methods for their use
Compounds, compositions, and methods that employ an eremophilane sesguiterpene are presented for controlling an arthropod pest population. The compounds have minimal adverse or toxic effects on...
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7109238 |
Calcilytic compounds
Novel calcilytic compounds and methods of using them are provided.
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7105482 |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one...
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7056947 |
Aza-peptide epoxides
The present invention provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention...
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7015244 |
Inhalable chemical debridement for COPD
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.
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7012091 |
Inhalable inhibitors of inflammation in the respiratory tract
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation to inhibit inflammatory responses in the respiratory tract are disclosed.
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6949584 |
TNP-470 species, polymer conjugates and use thereof
The present invention relates to conjugates of water-soluble polymers and o-(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the...
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6946441 |
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression,...
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6916843 |
Anti-inflammatory actions of cytochrome P450 expoxygenase-derived eicosanoids
Epoxyeicosatrienoic acids (EETs) are products of cytocrome P450 epoxygenases that have vasodilatory properties similar to endotheilum-derived hyperpolarizing factor (EDHF). The cytochrome P450...
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6903052 |
Nematicidal compositions and methods
The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6803382 |
Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
The invention relates to novel 1-oxaspiro[2,5]octan-6-ol derivatives of general formula (I): and also to a method for preparing them, and to their use in pharmaceutical compositions for use in...
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6777441 |
Triptolide analogs for the treatment of autoimmune and inflammatory disorders
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
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6774123 |
Methods and compositions for inactivating viruses
Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating...
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6773727 |
Use of gossypol and related terpenes for control of urban and agricultural pests
Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites...
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6740678 |
Method of treatment of cardiovascular injuries
The present invention provides a method for treating cardiovascular ailments. The method involves first screening an individual to determine their risk of having the potential for unstable plaques....
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6734204 |
Serotonin potentiation by oleamide analogs
Analogs related to oleamide are employed for potentiating the 5-HT 2A and 5-HT 1A responses to serotonin (5-HT). With respect to the potentiation of the 5-HT 2A receptor response, it is...
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6703415 |
Inhibitors of matrix metallaproteinases
The invention provides compounds that inhibit MMPs; methods for treating or preventing cancer, angiogenesis, arthritis, connective tissue disease, cardiovascular disease, inflammation or autoimmune...
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6693130 |
Inhibitors of epoxide hydrolases for the treatment of hypertension
The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure...
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6673834 |
Hydroperylene derivatives
Compounds of the formula I are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur.
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6638970 |
Substituted alkylene diamine compounds
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage...
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6632837 |
Compositions containing a selenium monobromide-oil reaction product and epichlorohydrin and methods of making the same
A composition of selenium monobromide-oil reaction product including a reaction product of selenium momobromide-in-oil prepared from eleostearic acid and selenium monobromide, which contains at...
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6620844 |
Method for reducing blood insulin levels by reducing in vivo cathepsin L activity
Methods and compositions are provided for modulating blood insulin levels of animals by targeting the gene and gene products of cathepsins, particularly cathepsins L, K, and S, and especially...
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6620843 |
Anticancer treatment using triptolide prodrugs
Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents...
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6566394 |
Salicylamide derivatives
Salicylamide derivatives represented by formulae ( 1 a ) and ( 1 b ); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active...
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6565865 |
Topical composition comprising a three membered cyclic compound-based cosmetic bonding agent
The present invention relates to cosmetic compositions that comprise: a) a safe and effective amount of a three membered functional cyclic bonding agent having the structure wherein X represents...
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6528539 |
Stable formulation containing fumagillin
The invention relates to a stable fumagillin formulation and to the method of use thereof in treating and/or combating intestinal infections.
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6489357 |
Tobacco cembranoids block the expression of the behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptors
The subject invention relates the use of cembranoids to inhibit nicotine addiction at the behavioral level. The subject host is sensitized to nicotine. Cembranoids are then administered to reduce...
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6486178 |
Indane derivatives
The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R 1 represents hydrogen atom, nitro...
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6462078 |
Epoxyvibsanin B
This invention relates to a new compound, epoxyvibsanin B, which can be used to treat an IL-12 overproduction-related disorder such as an inflammatory disease.
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6436993 |
Use of RAR antagonists as modulators of hormone mediated processes
In accordance with the present invention, it has been discovered that retinoic acid receptor (RAR) antagonists are capable of modulating processes mediated by other members of the steroid/thyroid...
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