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7625945 |
Andrographolide and analogues as inhibitors of TNFα and IL-1β expression
This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula:
wherein R 1 and R 2 are defined herein. It also relates to is a...
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7601854 |
Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata , especially to the new compounds of following structural formula:
and...
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7592368 |
Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
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7585882 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I:
wherein R 1 , R 2 ,...
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7547726 |
AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the...
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7538139 |
Sugar derivatives comprising oxiranes or α, β-unsaturated γ-lactones, process for their preparation and their utilisation as pesticides
A method for controlling pests, the method comprising applying an effective amount to pests or their locus of one or more compounds of general formula (I)
wherein R 1 and R 2 represent,...
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7514439 |
Oxime derivative and preparations thereof
The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]:
wherein Ring A is aryl or heteroaryl;
...
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7459481 |
Stimulation of CPT-1 as a means to reduce weight
This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1)...
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7375133 |
Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a...
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7345091 |
Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a...
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7323495 |
Synthetic lactone formulations and method of use
Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti-bacterial, anti-fungal and...
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7320997 |
Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a...
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7317008 |
Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The...
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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7285571 |
Herbal chemical composition for the treatment of cancer
The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer...
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7230013 |
C10 carbamoyloxy substituted taxane compositions
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7223792 |
Cytotoxic annonaceous acetogenins from Annona muricata
Acetogenins isolated from Annona muricata of the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective...
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7205289 |
Combinations of active ingredients with insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
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RE39530 |
3-amino-3-arylpropan-1-ol-compounds, their preparation and use
3-amino-3-arylpropan-1-ol compounds corresponding to the formula I
in which R 1 to R 5 , A and X have the meanings according to claim 1, and their preparation and use as medicaments.
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7189753 |
Preemptive prophylaxis of migraine
A method of preventing the headache phase of migraine in a human comprises administration of a 5HT 1 receptor agonist or administration of an over-the-counter or nonprescription drug to said human...
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7183316 |
Treatment of HPV caused diseases
Human papillomavirus (HPV) protein expression is downregulated in patients infected with HPV by administration of PPARγ ligand, selective inhibitor of cyclooxygenase-2 (COX-2), diaryl heterocycle,...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7132449 |
Inhibitors of cruzipain and other cysteine proteases
Compounds of general formula (I):
wherein R 1 , R 2 , Y, (X) o , (W) n , (V) m , Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors...
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7132448 |
High concentration topical insecticide containing insect growth regulator
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7078435 |
Autoinducer compounds
Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated...
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7078434 |
Use of Ginkgo extract
The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing...
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7078404 |
Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use
The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of formula...
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7056946 |
C10 carbonate taxane compositions
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7053118 |
Lactone compounds and methods of use
The subject invention provides novel compositions of biologically active compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject...
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7037937 |
Cytotoxic compounds
Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular...
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7026353 |
Inhibition of Gram positive bacteria
A method of inhibiting the growth of a Gram positive bacterium, the method comprising treating the bacterium with an effective amount of one or more furanones having the Formula as set out in the...
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7008666 |
Method of inhibiting overactivity of phagocytes or lymphocytes in an individual
The invention relates to a method of inhibiting myeloperoxidase activity in neutrophils in an individual by administering to the individual an effective amount of a lignan, where said lignan is...
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6992104 |
C7 carbonate taxane compositions
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6984662 |
High concentration topical insecticide containing insect growth regulator
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an...
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6969731 |
Protease inhibitors that overcome drug resistance
HIV protease inhibitors are among the most powerful drugs in suppressing HIV in human patients. However, HIV developed resistance to all protease inhibitor drugs so far marketed or used in clinical...
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6964981 |
Tetrahydrofuran derivatives and their use as NK-1 antagonists
The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic...
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6906088 |
Taxanes having a C10 carbamoyloxy substituent
Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6906051 |
Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I:
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6900242 |
Lactone formulations and method of use
Compounds of Formula Ia and Ic having a lactone structure and an methylene group at the alpha-position of the lactone structure and methods for using and making the compounds have been disclosed....
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6878744 |
Vitamin C compositions
Vitamin C compositions comprise a Vitamin C compound, preferably a mineral ascorbate, and at least one compound of the group of 4-hydroxy-5-methyl-3(2H)-furanone and 3-hydroxy kojic acid.
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6878742 |
Heterocyclic sulfonamide inhibitors of beta amyloid production
Compounds of Formula (I),
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or...
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6875784 |
Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are...
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6864283 |
Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
Compounds of formula (I) wherein R 1 is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C 1 -C 18 alkyl, substituted or unsubstituted C 2 -C 18 ...
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6864278 |
Antifungal agents of sordarin derivatives
Sordarin derivatives prepared from C-11-hydroxysordarin are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of...
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6835747 |
Ft-0554a substances and process for the preparation thereof
The present invention relates to obtain novel FT-0554A substance useful for infectious disease of parasite, especially helminth and more particularly relates to the novel FT-0554A substance...
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6831105 |
Compositions comprising ether compounds and pharmaceutical uses therefor
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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6828328 |
Analgesic combination of muscarinic agonists
This invention relates to the combination of muscarinic agonists with narcotic analgesics, non-steroidal anti-inflammatory drugs or other analgesic drugs and to their use as antinociception (pain...
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6818670 |
Active ingredient combination having insecticidal and acaricidal characteristics
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the groups W,...
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