Matches 251 - 300 out of 381 < 1 2 3 4 5 6 7 8 >
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5162368 Butalactin and its use as pharmaceutical  
Butalactin, a compound of the formula I ##STR1## can be produced by cultivation of Streptomyces species Y-86,36923. Butalactin has an antibiotic activity.
5158962 Fungicidal substituted amino acid amides  
Fungicidal substituted amino acid amides of the formula ##STR1## in which Ar and Ar' are identical or different and represent unsubstituted or substituted aryl, unsubstituted or substituted...
5153218 N,N',N'-trisubstituted-bis-amino-3-methylene-2,4(3H,5H)-furandione inhibitors of acyl-CoA:cholesterol-acyl transferase  
The compound of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or...
5145703 Thio-alkanones, process for their preparation and their use  
The invention relates to new thio-alkanones of the formula ##STR1## in which X represents an oxygen or sulphur atom, R 1 represents hydrogen or a C 1 -C 2 -alkyl group and the broken lines...
5134128 Anti-inflammatory furanones  
New 5-hydroxy-2-furanone compounds having anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.
5128370 Furans and lactones from sterptomycetes and the use thereof  
New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof. It is possible with the aid of various streptomycetes species to prepared new compounds...
5116869 2-substituted-2-cyclopentenones  
2-Substituted-2-cyclopentenones represented by the formula (I): ##STR1## wherein A is a hydroxyl group or ##STR2## and B is a hydrogen atom or A and B are bonded together to form one bonding arm; ...
5112848 Furan and pyrrole containing lipoxygenase inhibiting compounds  
Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.
5084464 Conjugated γ-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient  
The present invention provides conjugated γ-hydroxybutenolide compounds represented by the general formula: ##STR1## wherein R represents, when n is 1, furyl groups, thienyl groups or naphthyl...
5071872 Method for improving interleukin-2 activity using aci-reductone compounds  
A method for improving interleukin-2 induced lymphocyte killing of cancer cells comprises administering to a patient having cancer an effective amount of at least one aci-reductone compound...
5064856 Novel HMG-CoA synthase inhibitors  
Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##
5059611 Anti-inflammatory 5-hydroxy-2-furanones  
New 5-hydroxy-2-furanone compounds have anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.
5053430 Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new 2,7-diamino-1,2,3,4-tetrahydronaphthalenes and processes for their preparation  
Novel compounds having the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
5043459 Saccharoascorbic acid derivatives and production thereof  
This invention relates to novel saccharoascorbic acid derivatives and their production. The derivatives are represented by the general formula set forth below, for example, an amido, a thioester or...
5043356 Composition and method for rejuvenating skin using vitamin A propionate  
Topically applied compositions for the accelerated rejuvenation of skin and an associated method of skin care treatment are disclosed utilizing vitamin A propionate of the general formula ##STR1##...
5032590 Substituted hydroxylamines  
Substituted hydroxylamines of the formula ##STR1## in which R 1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia...
5032611 Lactone compound of agricultural utility  
Disclosed in the present invention are: a substance F-0368 or salts thereof having the following structural formula ##STR1## a method for production of the substance F-0368 or salts thereof,...
5026725 Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones  
This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and...
5002967 Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase  
The compounds of the present invention comprise substituted phenolic thioethers, sulfoxides, and disulfides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the...
4980371 Antiretroviral furan ketones  
Furan ketone derivatives thereof having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula ##STR1## wherein Y is a bond, oxygen or divalent...
4977185 Antiretroviral aryloxy substituted furan ketones  
Novel furan ketone derivatives having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula ##STR1## wherein Y represents a bond, oxygen or...
4954524 Carbacylcins, their preparation and use as medicinal agents  
Carbacyclin derivatives of Formula I ##STR1## wherein R 1 is hydrogen or OR 2 , wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, ##STR2## or a heterocyclic residue; or R 1 is NHR 3 wherein R 3...
4952605 Manoalide analogs  
Analogs of the marine natural product manoalide are useful in treating mammals, including humans, in need of a drug having analgesic/anti-inflammatory, immunosuppressive, and/or antiproliferative...
4950818 Method for treating ulcer  
A novel and useful method for treating and/or preventing ulcer in human beings is provided which comprises administering an effective amount of a pharmaceutical composition comprising at least one...
4946845 Naphthalene anti-psoriatic agents  
Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R 1 and R 2 are the same and are lower alkoxy or optionally substituted phenoxy, R 3 ...
4945107 Insect attractant  
As an attractant composition for cockroaches, a furanone compound having the formula ##STR1## where R' is H or CH 3 ; R" is H, a straight chain or cyclic hydrocarbon moiety of 1 to 12 carbon...
4943584 (p-Phenoxyphenoxy)-methyl-five-membered hetaryls  
Novel (p-phenoxyphenoxy)-methyl-five-membered heeroaromatic radicals of the formula ##STR1## where the substituents have the following meanings: R 1 , R 2 , R 3 hydrogen, halogen, C 1 -C 8 ...
4914111 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents  
Thiophene (or furan)-2-sulfonamides with a 4-benzyl substituent are effective in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.
4906658 Fluoro-sulfones  
Compounds of Formula I ##STR1## the pharmaceutically acceptable salts, and the gamma-lactone form thereof are described. They are antagonists of leukotrienes and SRS-A.
4904681 D-cycloserine and its prodrugs as cognitive enhancers  
The compound D-4-amino-3-isoxazolidone, its pharmaceutically-acceptable salts and its prodrug compounds are described as having cognitive-enhancing activity.
4897397 Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents  
Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
4874782 Furanone derivatives  
This invention provides certain furanone derivatives, their pharmaceutical formulations, and their use in a method for treating inflammation, asthma, or allergies.
4871756 Leukotriene antagonists  
Compounds having the formula: ##STR1## are antagonists of leukotrienes of C 4 , D 4 , E 4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic,...
4855319 Control of pests with annonaceous acetogenins  
Tetrahydrofuranoid acetogenins characteristic of the Annonaceae plant family have been found to have potent pesticidal and feeding deterrent activity against a diverse variety of pests such as...
4855318 Iodopropargyl ethers useful as antimicrobial agents  
Iodopropargyl ethers of the formula ##STR1## wherein A represents oxygen or a methylene group, R 1 denotes hydrogen or lower alkyl, R 2 and R 3 are identical or different and represent...
4855320 5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them  
The present invention provides 5-arylalkyl-4-alkoxy-2(5H)-furanones of the formula: ##STR1## wherein the oxygen atoms on C-5 and C-α, relative to one another, are in the threo-position, with the...
4853403 3-phenylthiomethylstyrene derivative, process for preparing the same, and antiallergic agent and tyrosinekinase inhibiting agent containing the same  
A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R 1 is hydrogen atom or R 2 is hydrogen atom, a process for...
4851435 Antiviral and antitumor xanthate pharmaceutical compositions  
The invention refers to antiviral and antitumor compositions which are useful for the control of viruses and tumors and which, in addition to a known antiviral or antitumor active xanthate, contain...
4845123 Reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by sustained-release inhibitors of β- g  
A method for the reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by inhibiting the activity of β-glucuronidase in a mammal which comprises the...
4843093 Butyrolactone derivatives, process for production thereof and use therefor  
Butyrolactone derivatives having the formula ##STR1## wherein R is a C 4 -C 10 alkyl group, which have an appetite-regulating effect, a process for their production, and compositions containing...
4839385 Use of manoalide and its derivatives for modifying calcium homeostasis  
Compounds derived form the marine sponge Laffariella variabilis and known by the name manoalide, and its derivatives, modify calcium homeostasis.
4810724 Fungicidal compositions  
N-Acylated N-phenyl-aminotetrahydro-2-furanones of the formula ##STR1## wherein R represents C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy or halogen, R 1 represents C 1 -C 3 -alkyl, C 1 -C 4 ...
4797417 Furanone derivatives, process for preparation thereof and use thereof  
The invention relates to novel furanone derivatives, having an aldose reductase-inhibitory activity, of the formula ##STR1## wherein A is a lower alkylene group, R 1 is a carboxy, hydroxy,...
4786651 Treatment of cutaneous hyperproliferative dermatoses with manoalide  
Manoalide and its derivatives are useful in the treatment of cutaneous hyperproliferative dermatoses.
4766148 Biphenylylpropionic acid derivative and pharmaceutical composition containing the same  
Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R 1 is a lower...
4743619 Method of treating hepatitis  
The invention disclosed herein provides a method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected...
4738984 Antirhinovirus agents  
Compounds of the following general structure are useful as antirhinovirus agents: ##STR1## wherein R is a straight or branched hydrocarbon chain having from 12 to 16 carbon atoms and is saturated...
4728666 Heteroaromatic acetylenes useful as antihypertensive agents  
Heterocyclic acetylenes of the formula (I): ##STR1## wherein Y and R 1 are substituents such as hydrogen, alkyl, alkoxy, chloro or fluoro, m is 0-2, R 2 is branched alkyl and Het is an aromatic...
4725302 Substituted phenylhydrazines and phenyloxadiazolinones and pesticidal usage thereof  
Phenylhydrazines of the formula I ##STR1## wherein R 1 is --A--R--Z, A is oxygen, sulfur, ##STR2## R is C 1 -C 6 -alkylene, C 1 -C 6 -haloalkyl-C 1 -C 6 -alkylene, C 1 -C 6 -alkoxy-C 1 ...
4680307 Carbacyclin analogs  
A compound of the formula: ##STR1## wherein X 1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R a and R b are each independently a hydrogen atom, a C 1 -C 4 ...
Matches 251 - 300 out of 381 < 1 2 3 4 5 6 7 8 >