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5234950 |
Tetrahydrofuran derivatives
The invention concerns a heterocyclic derivative of the formula I, ##STR1## wherein Ar 1 is optionally substituted phenyl or naphthyl; A 1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene...
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5234946 |
Substituted alkylamine derivatives
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
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5229418 |
Carboxylic acid derivatives
The invention relates to a salt of a basic histamine H 2 -receptor antagonist of formula (I) ##STR1## and a complex of bismuth with a carboxylic acid selected from tartaric acid, citric acid and...
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5227400 |
Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
A taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT 1 , T 1 is hydrogen, hydroxyl protecting group, or --COT 2 , T 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 ...
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5219886 |
Mercapto-acylamino acids
Novel mercapto-acylamino acids of the formula ##STR1## wherein Q is hydrogen or R 7 CO--; R 1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R 2 is hydrogen; lower alkyl; cyclolower...
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5217991 |
Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment...
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5216013 |
Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives
Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular...
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5196454 |
Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
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5192800 |
Glutaramide diuretic agents
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent...
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5190961 |
Thiourea derivatives and antimicrobial agent and antulcer agent containing the same
Thiourea derivatives represented by the formula (I) ##STR1## wherein R 1 and R 2 are the same or different and each represents a lower alkyl group, or R 1 or R 2 taken together represent a...
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5189035 |
Fungicidal furanone derivatives
The invention provides furanone derivatives of the general formula ##STR1## in which R 1 represents a halogen atom or an optionally substituted alkyl or alkoxy group, R 2 represents a halogen...
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5187192 |
Cyclobutyl derivatives having lipoxygenase inhibitory activity
Compounds of the structure ##STR1## where M is a pharmaceutically acceptable cation or a metabolically cleavable group, R is alkyl, cycloalkyl or --NR 1 R 2 , where R 1 and R 2 are hydrogen,...
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5183818 |
Arylalkylether and arylalkylthioether inhibitors of lipoxygenase enzyme activity
The present invention provides compounds having the structure Y-Het-[Q 1 ]-X-[Q 2 ]-Z which inhibit the catalytic action of lipoxygenase enzymes, particularly 5-lipoxygenase, and thereby reduce...
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5182300 |
Furosemide salts
Compounds of the formula ##STR1## wherein AA is a basic amino acid in optically active or racemic form having better bio-availability and a method of treating asthma.
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5179127 |
Halopropargyl acyl compound, compositions, microbicidal uses and processes of preparation
Compounds of the formula ##STR1## wherein A is selected from the group consisting of (1) phenyl, (2) naphthyl, (3) phenyl substituted with one or more halo, cyano, (C 1 -C 4 )alkyl, nitro, (C 1 ...
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5177081 |
Method and pharmaceutical composition for the treatment of schizophrenia
Persons suffering from negative symptoms of schizophrenia can be successfully treated using a histamine H 2 -antagonist which crosses the blood-brain barrier so as to interact with histamine-H 2 ...
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5162364 |
4-aminobutyric acid compounds, compositions, and method of use for treating disorders related to a dysfunction of GABA.sub.B receptors
A compound of formula (I): ##STR1## in which R, R 1 and R 2 are as defined in the description. Medicinal product, which is useful in treating disorders related to a dysfunction of GABA B receptors.
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5158973 |
Process and composition for inhibiting and controlling bacterial growth
A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount,...
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5153218 |
N,N',N'-trisubstituted-bis-amino-3-methylene-2,4(3H,5H)-furandione inhibitors of acyl-CoA:cholesterol-acyl transferase
The compound of the formula: ##STR1## in which X, Y and Z are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl or...
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5134128 |
Anti-inflammatory furanones
New 5-hydroxy-2-furanone compounds having anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.
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5124322 |
Dipeptide collagenase inhibitors
Novel compounds of formula (I), salts, solvates and hydrates thereof: ##STR1## in which: R 1 and R 2 are independently hydrogen; alkyl; alkoxy; halogen; or CF 3 ; R 3 is hydrogen; acyl, such...
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5120759 |
Tetrahydronaphthalene derivatives for improving short-term memory
Novel compounds of the formula ##STR1## wherein R 1 is lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkylthio-lower-alkyl or furyl, R 2 is lower-alkyl, phenyl-lower-alkyl or...
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5118683 |
Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
Compounds of the formula I ##STR1## wherein R 5 represents C 1 to C 6 -alkyl or the group --(CH 2 ) n --Z--(CH 2 ) m --Ar; Z represents O, S or --CH 2 --; n represents an integer of 1...
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5118704 |
Substituted 2-aminotetralins useful as dopaminergics
Optically active or racemic compounds are provided having the formula ##STR1## where R 2 , R 3 , R 4 and R 6 are defined in the specification; R 1 is selected from the group consisting of...
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5104874 |
Benzoquinone antiallergy and antinflammatory agents
A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergic and antiinflammatory agents.
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5093356 |
Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5091426 |
5-phenyl-2-furan ketones and use as antiepileptic agents
A method of preventing epileptic seizures in a human or lower animal subject susceptible to said seizures, comprising systemically administering to said subject a safe and effective amount of a...
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5090990 |
Industrial antimicrobial:uses for 2-(2-bromo-2-nitroethenyl)-furan
2-(2-bromo-2-nitroethenyl)-furan can be used as an antimicrobial in broad spectrum of uses. A novel process for preparing 2-(2-bromo-2-nitroethenyl)-furan has been found in which furfural is...
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5084464 |
Conjugated γ-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient
The present invention provides conjugated γ-hydroxybutenolide compounds represented by the general formula: ##STR1## wherein R represents, when n is 1, furyl groups, thienyl groups or naphthyl...
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5077303 |
Oxirane phenyl esters and fungicides containing these
Esters of the general formula I ##STR1## where A is hydrogen, alkyl, cycloalkyl, cycloalkenyl, naphthyl, biphenyl, hetaryl or phenyl, these radicals being substituted or unsubstituted, and X is CH...
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5077306 |
Fungicidal N,N'-diacylaminals
Fungicidal N,N'-diacylaminals of the formula ##STR1## in which R 1 is optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl, R 2 and R 3 are hydrogen or various organic...
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5075301 |
Furan derivatives useful for the treatment of gastro-intestinal disorders
A furan derivative and a pharmaceutically acceptable salt thereof having gastrointestinal enterokinetic activity which is expected to be used in a broad spectrum of diseases associated with...
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5068249 |
Aqueous ranitidine compositions stabilized with ethanol
The stability of aqueous formulations of ranitidine or a physiologically acceptable salt thereof is enhanced by the addition of ethanol.
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5064827 |
Polyhydroxybenzyloxpropanolamines
Compounds of the present invention, are represented by the general formula ##STR1## wherein R 1 group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon...
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5059611 |
Anti-inflammatory 5-hydroxy-2-furanones
New 5-hydroxy-2-furanone compounds have anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.
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5059623 |
Substituted cycloalkyl- and heterocyclyl-carboxanilides
A substituted cycloalkyl- or heterocyclyl-carboxanilide of the formula (I) ##STR1## in which X stands for an unsubstituted or an alkyl-substituted cycloalkyl or an unsubstituted or an...
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5053430 |
Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new 2,7-diamino-1,2,3,4-tetrahydronaphthalenes and processes for their preparation
Novel compounds having the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
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5045104 |
Synergistic compositin of 2-(2-bromo-2-nitroethenyl) furan and 2-bromo-2-nitropropane-1,3-diol and uses thereof
A synergistic mixture of 2-(2 bromo-2-nitroethenyl)furan and 2-bromo-2-nitropropane-1,3-diol is disclosed. The synergistic mixture can be used as an antimicrobial in a broad spectrum of uses; the...
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5045564 |
Anti-inflammatory 2-furanones
New 2-furanone compounds have calcium channel antagonist activity and are useful as anti-inflammatory agents and in treating psoriasis.
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5036081 |
Calcium absorption promoter
Alpha-glucosidase inhibitor is provided as a promoter of calcium absorption in mammals. The examples of the inhibitor are shown by the formula; ##STR1## wherein A stands for a C 1 -C 10 acyclic...
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5032590 |
Substituted hydroxylamines
Substituted hydroxylamines of the formula ##STR1## in which R 1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia...
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5023272 |
Use of 5-phenyl-2-furan esters and amides as antiepileptic agents
A method of preventing epileptic seizures in a human or mammal subject susceptible to said seizures, comprising systemically administering to said subject a safe and effective amount of a compound...
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5023269 |
3-aryloxy-3-substituted propanamines
The present invention provides 3-aryloxy-3-substituted propanamines capable of inhibiting the uptake of serotonin and norepinephrine.
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5021458 |
Amine derivatives and fungicides containing the same
Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as...
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5015644 |
Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the...
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5010104 |
Tricyclic compounds
Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and...
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5007790 |
Sustained-release oral drug dosage form
Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which...
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5008290 |
Sulphonamidoethyl compounds and pharmaceutical compositions comprising these compounds
The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.
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4999042 |
Phenyl oximino-acetate fungicides
Compounds of the fomrula (I): ##STR1## and sterioisomers thereof, wherein X is halogen, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl,...
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4997848 |
Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl of hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond,...
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