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5693666 |
6,7-modified paclitaxels
The present invention provides paclitaxel derivatives of formula I ##STR1## and pharmaceutical compositions.
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5688819 |
Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH...
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5688817 |
Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics
Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a...
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5665763 |
Therapeutic phenoxyalkylpyridazines and intermediates therefor
Compounds of the formula ##STR1## wherein: R 1 , R 2 , R 3 and R 4 are as defined in the specification, Y is alkylene of 3 to 9 carbon atoms, R 5 is alkoxycarbonyl, alkyltetrazolyl, phenyl...
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5665767 |
Crystalline cyclodextrin complexes of ranitidine hydrochloride, process for their preparation and pharmaceutical compositions containing the same
The present invention relates to cyclodextrin inclusion complexes of ranitidine hydrochloride which exhibit a novel, to date unknown crystalline structure, being significantly different from those...
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5665768 |
Heteroaryl cycloalkenyl hydroxyureas
Certain novel heteroaryl cycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein...
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5663198 |
Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation
Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation. Drug formulations comprising micronized particles...
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5658904 |
1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5658942 |
Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond,...
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5656652 |
Compositions containing histamine-H.sub.2 -receptor antagonists at low dosage
Compositions for oral administration for the treatment of gastric disorders comprising histamine H 2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H 2 ...
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5650397 |
Antioccidial method
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified o-phenylenediamine or benzimidazole. The present invention is also directed...
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5648381 |
Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof
Compounds of use in therapy and having the formula: ##STR1## in which R 2 and R 3 independently denote H, C 1 -C 4 alkoxy or OH and (A, B)=(oxygen, oxygen) in which case one out of R and R 1 ...
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5646180 |
Treatment of the CNS effects of HIV
Methods and compositions for treating the central nervous system (CNS) effects of HIV, particularly AIDS related dementia.
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5643960 |
Method of delaying onset of alzheimer's disease symptoms
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The method involves the administration to...
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5635531 |
3'-aminocarbonyloxy paclitaxels
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
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5633244 |
Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic
A synergistic pharmaceutical combination or composition is disclosed for the treatment of gastritis and peptic ulcer containing a therapeutic amount of a histamine H 2 receptor blocking agent,...
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5629026 |
Compositions containing histamine-H2-receptor antagonists at low dosage
Compositions for oral administration for the treatment of gastric disorders comprising histamine H 2 -receptor antagonist and antacid, optionally buffered to promote local absorption of the H 2 ...
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5622980 |
Oral compositions of H2-antagonists
The present invention provides a pharmaceutical composition for the oral administration of an H 2 -antagonist. The composition includes an H 2 -antagonist and a silicate taste-masking agent...
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5610181 |
Derivatives of amino-ascorbic acid, the processes for their preparation and use
The invention relates to the process for the preparation of new derivatives of amino-ascorbic acid, their acid and alkali salts, processes for preparation and action. According to this invention...
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5607978 |
Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime,...
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5604228 |
Substituted guanidines having high binding to the sigma receptor and the use thereof
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and...
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5602172 |
Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
The present invention provides methods for treating Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium parvum in a subject in need of such treatment. The methods comprise...
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5599817 |
Xanthine derivatives as diuretic agents
A method for stimulating diuresis comprising administering a composition comprising 8-(3-oxocyclopentyl)-1,3-di-n-propyl-7H-purine-2,6-dione and, optionally, a loop diuretic, is disclosed.
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5589490 |
Benzoic acid substituted derivatives having cardiovascular activity
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5587367 |
Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol
A pharmaceutical or cosmetic composition is disclosed comprising in combination a retinoid and a sterol capable of inhibiting the biosynthesis of cholesterol resulting in a synergistic effect in...
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5580893 |
Nitroxyalkylamide derivatives
Nitroxyalkylamide compounds having the formula: R 1 --(A) n --CONH--B'--ONO 2 wherein R 1 is an optionally substituted furyl, furyloxy, thienyl, thienyloxy, isoxazolyl, phenoxy, phenylthio or...
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5578632 |
Medicaments for the treatment of gastrointestinal dysfunction
The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R 1 represents a hydrogen atom or a C 1 -10 alkyl, C 3 -7 cycloalkyl, C 3 -7 cycloalkyl-(C 1 -4) alkyl, C...
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5574054 |
Quaternary ammonium salts and use thereof as medicine
Novel quaternary ammonium salts having utility in the medical field for treating gastrointestinal disorders.
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5571825 |
Method of selectively inhibiting prostaglandin G/H synthase-2
The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a...
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5567735 |
Therapeutic amides
Amides having formula I: ##STR1## wherein E, X, R 2 and R 3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo...
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5565466 |
Methods for modulating the human sexual response
The invention is directed to improved methods for modulating the human sexual response by administering a vasodilator to the circulation by a route of administration that avoids the "first-pass"...
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5559144 |
Furyl and thienyl alkynyl-N-hydroxy urea derivatives
Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or...
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5559150 |
N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
The present invention is directed to novel compounds that are non-peptidic thrombin inhibitors. The compounds have the structure: ##STR1## and pharmaceutically acceptable salts thereof; wherein R 1...
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5554633 |
Substituted amines as tachykinin receptor antagonists
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR 9 , where R 9 is...
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5547969 |
Method for the treatment of bradyphrenia in Parkinson's disease patients
The neuropsychiatric symptom of bradyphrenia in a Parkinson's Disease patient may be ameliorated by treating the patient with a histamine H 2 -antagonist that passes the blood brain barrier....
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5543425 |
Method of inhibiting platelet aggregation using phenyl amidine thio derivatives
This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##
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5536746 |
Insecticidal phenylhydrazine derivatives
Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes,...
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5532267 |
Amidinonaphthyl furancarboxylate derivatives and acid addition salts therof
Amidinonaphthyl furancarboxylate derivatives of the formula I ##STR1## wherein A is a single bond or A denotes (a) a phenyl group, cyclopentyl group, or cyclohexyl group, (b) an alkenylphenyl...
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5516789 |
Lipoxygenase and cyclooxygenase inhibiting compounds
Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B 4 ,...
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5514694 |
Peptidyl ketoamides
A novel class of peptide α-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally...
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5514702 |
Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity
The present invention provides certain (substituted carbocyclic aryl)amidoalkyl- and (substituted heterocyclic aryl)amidoalkyl-N-Hydroxy urea compounds which inhibit lipoxygenase enzyme activity...
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5502079 |
N-phenylalkyl substituted α-amino carboxamide derivatives and process for their preparation
N-phenylalkyl substituted α-amino carboxamide derivatives of formula (I) ##STR1## wherein R is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted...
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5494926 |
2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR 8 (R 8 is H or C...
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5484800 |
Lipid-based liquid medicinal composition
The present invention is directed to liquid medicinal suspension compositions for the administration of doses of active pharmaceutical agents such as H 2 -antagonists. H 2 -antagonists are known...
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5482966 |
Oxime derivatives
The invention concerns oxime derivatives of the formula I ##STR1## wherein R 4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and...
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5478854 |
Deoxy taxols
Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of...
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5476669 |
Method for treatment of gastro intestinal disorders
A method is disclosed for preventing the recurrence of duodenal ulcer associated with Campylobacter pylori (Helicobacter pylori) infection in a patient suffering from duodenal ulcer disease...
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5468774 |
Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A.sub .
There are disclosed compounds of the formula: ##STR1## wherein X is O; R 1 and R 2 are each, independently, hydrogen, C 1 -C 10 alkyl, C 3 -C 20 cycloalkyl, phenylloweralkyl, or...
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5466690 |
Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is...
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