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6051571 Methods for treating medical dysfunctions and diseases using furan nitrone compounds  
Disclosed are methods for treating a patient with an acute central nervous system or cardiovascular disorder or a neurodegenerative, autoimmune or inflammatory disease using a pharmaceutical...
6048894 Substituted amide derivatives  
The present invention relates to a compound represented by general formula (I) or a pharmaceutically acceptable salt or ester thereof: ##STR1## [wherein each of ##STR2## is an aryl group or an...
6048882 Prophylactic and therapeutic agent for hepatic diseases  
Hepatic diseases can be prevented or treated by administering an isoprenylamine derivative represented by the general formula (II) ##STR1## [wherein n represents an integer of 4-12, m represents an...
6037365 Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation  
This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of...
6034109 Method for protection of heart by limiting metabolic and ionic abnormalities developed during ischemia following ischemia or resulting from ischemia  
A therapeutic and prophylactic method for protection of heart or heart tissue by limiting metabolic and ionic abnormalities developed during, following or associated with ischemia by administering...
6017956 N,N-disubstituted amic acid derivatives  
The present invention relates to a compound of the formula (I): ##STR1## wherein Ar 1 , Ar 2 , Ar 3 and Ar 4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon...
6017947 Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV  
useful for the inhibition of the replication of HIV-1, in vitro and in vivo.
6017914 Benzo[b]thiophene compounds, intermediates, formulations, and methods  
This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods.
6013666 Oxirane carboxylic acid derivative and its manufacturing method  
6008219 Bicyclic amine derivatives and their use as anti-psychotic agents  
This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D 3 receptors, in particular as antipsychotic agents.
6004988 Carboxylic acid derivatives, their preparation and their use  
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
5998469 Thioether furan nitrone compounds  
Disclosed are novel thioether furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating...
5998468 Furanone endothelin antagonists  
Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of...
5994396 Furansulfonic acid derivatives and pharmaceutical compositions containing the same  
Disclosed are furansulfonic acid derivatives and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating neurodegenerative,...
5977168 Wood preservative compositions containing dimethylfurancarboxyanilide derivatives  
A dimethylfurancarboxyanilide compound of the formula (I): ##STR1## wherein R 1 and R 2 are the same or different and each is hydrogen, (C 2 -C 6 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6...
5977169 Substituted tetronic acids useful for treating HIV and other retroviruses  
This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the...
5968910 Compositions containing two or three inhibitors of different HIV reverse transcriptases  
A composition and method for the prevention or treatment of HIV-1 infection comprising an HIV-1 reverse transcriptase-inhibiting heterocyclyl carb(ox/thio)anilide compound, a second HIV-1 reverse...
5952316 2-amino-1,3-propanediol compound and immunosuppressant  
2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted...
5942541 Substituted amino acid amide derivatives their preparation and use as fungicides  
There are described new amino acid amide derivatives, some of which are known, of the formula (I) ##STR1## in which R 1 to R 8 have the meaning given in the description, and a process for their...
5935776 Small molecule inhibition of RNA/ligand binding  
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A...
5932196 Buffered emulsion compositions containing actives subject to acid or base hydrolysis  
The present invention are for emulsion compositions and the process for making such compositions containing biological and cosmetic actives subject to hydrolysis of actives during processing and...
5922767 Substituted benzylurea derivatives and medicine containing the same  
Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1): ##STR1## wherein R 1 and R 2 are independently H, a halogen atom, or an alkyl or alkoxyl...
5914351 Anti-viral aromatic hydrazones  
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
5912248 Excitatory amino acid receptor antagonists  
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO 2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
5889038 Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds  
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
5889033 Method and composition for the treatment of apathy-amotivation syndrome  
In accordance with the present invention, neuropsychiatric symptoms of apathy-amotivation syndrome and particularly those symptoms in: Alzheimer's disease, multiple sclerosis, Huntington's chorea,...
5874464 Conformationally constrained diacylglycerol analogues  
Conformationally constrained diacylglycerol analogues, pharmaceutical compositions comprising such analogues, and methods of using such analogues as agonists and antagonists of protein kinase C.
5872121 Pesticidal hydrazide derivatives  
A compound of the formula ##STR1## wherein R is a) phenyl; phenyl(C 1 -C 4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of...
5869067 Bi-aromatic compounds and pharmaceutical and cosmetic compositions  
The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
5863947 Phenylglycine derivatives useful for treating disorders of the central nervous system  
A pharmaceutical compound of the formula: ##STR1## in which R 1 is hydrogen, hydroxy or C 1 -6 alkoxy, R 2 is hydrogen, carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or...
5856323 Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase  
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl...
5834460 Serine derivative  
A serine derivative represented by the general formula (I) ##STR1## (symbols in the formula represent the following meanings; X: a sulfur atom or an oxygen atom, Y: a nitrogen atom or CH, R 1...
5834508 Ketone derivatives  
A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent...
5824704 Anti-viral aromatic O-alkylated oximes, ethers and thioethers  
Compounds of the formula ##STR1## These compounds are useful for inhibiting the growth or replication of retroviruses such as HIV.
5824691 Guanidine derivatives as inhibitors of Na.sup.+ /H.sup.+ exchange in cells  
Guanidine derivatives of the formula: ##STR1## wherein Y is C--R 1 (in which R 1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) R 2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., ...
5821267 Amidino derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses amidino derivatives useful as nitric oxide synthase inhibitors.
5807886 Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase  
Compounds of the formula (I) ##STR1## wherein D represents a 5-membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by...
5770620 Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors  
The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using...
5750561 Compositions containing taxane derivatives  
The invention provides new compositions containing taxane derivatives, consisting of solutions of such derivatives in a solvent mixture composed of ethanol and polysorbate. These compositions are...
5750559 Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non-steroidal anti-inflammatory drugs  
The antireactive-antiasthmatic effect of inhaled loop diuretics is potentiated by the use of a combination of a loop diuretic and a non-steroidal anti-inflammatory drug as an inhalant for combating...
5744474 Treatment of incontinence  
Urinary incontinence in humans is treated by administration of venlafaxine or a compound chosen from a series of aryloxy propanamines.
5733931 Cyclohexanediurea derivative and process for its production  
The present invention provides a cyclohexanediurea derivative, inclusive of its salt, represented by the following formula (I): ##STR1## wherein R 1 and R 2 are the same or different and they...
5733924 DC 107 derivatives and treatment methods  
DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, wherein R 1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl,...
5733935 Hydroxylamine derivatives and fungicides containing the same  
A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R 1 and R 2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group,...
5726201 Gemfibrozil containing pharmaceutical compositions  
The invention relates to oral solid pharmaceutical composition containing as active ingredient gemfibrozil and conventional pharmaceutical auxiliary agents comprising as surfactant...
5725878 Pharmaceutical composition comprising HIV protease inhibiting compounds  
A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable...
5714142 Method and compositions for increasing the serum half-life of pharmacologically active agents by binding to transthyretin-selective ligands  
Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active...
5714484 α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors  
Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease...
5708021 Debittered ranitidine preparation  
Ranitidine salts with polycarboxylic acids, such as copolymers of acrylic and/or methacrylic acid with their lower alkyl esters, are water-soluble salts with a very reduced bitter taste. The salts...
5696151 Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants  
Compounds of the formula ##STR1## wherein X is O or S, useful for the inhibition of the replication of HIV-1 and reverse transcriptase mutants thereof, in vitro and in vivo.
Matches 201 - 250 out of 638 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >