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7622465 |
Costunolide derivatives
Disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a...
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7605158 |
Carbamoyl-type benzofuran derivatives
The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]:
wherein Ring Z is a group of the formula:
etc.; A is a single bond, and the like; Y is a...
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7595064 |
Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals
A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii)...
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7585888 |
Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
This invention relates to novel benzofuran and benzothiophene derivatives of the general formula
and their use for the treatment of hyper-proliferative disorders.
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7579023 |
Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals
A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii)...
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7544676 |
Sulfamoyl benzamides and methods of their use
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
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7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I)
or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
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7538137 |
1-O-β-D-glucopyranosylgeraniol-10,5-olide and use thereof
A novel natural compound having various therapeutically effects is provided. The compound is obtainable from Sibiraea leaves by aqueous extraction and is represented by a formula (1) as follows.
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7534903 |
Use of amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl-compounds in the treatment of cardiac arrhythmia and other disease states
The use of compounds corresponding to formula I:
in which R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meanings given in the description for treating cardiac arrhythmias and other disease...
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7504428 |
2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
The present invention a method of treating anxiety by administering compounds that are active on the GABA B receptor, having formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as...
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7498357 |
Chalcone compounds
The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In...
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7470724 |
Phosphonate compounds having immuno-modulatory activity
The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of...
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7420001 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7419967 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7393825 |
Microdose therapy
Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve...
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7378441 |
Resistance-repellent retroviral protease inhibitors
Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV...
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7371774 |
Benzofurans and benzothiophenes
The invention relates to compounds of the general formula (I) below:
in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1.
These compounds can be used in the treatment of...
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7351735 |
Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
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7332522 |
Liver function protecting or ameliorating agent
A liver function protecting or improving agent which comprises a compound represented by the formula (I)
{in the formula (I), R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 may be the...
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7273886 |
Benzofuran inhibitors of factor VIIa
Compounds of Formula I are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds...
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7241756 |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
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7220749 |
Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated...
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7208467 |
Lipid-altering compositions for the treatment of infertility
SR-BI is present at relatively high levels on the membranes of hepatocytes and steroidogenic tissues, including the adrenal gland, testes, and ovaries, where it mediates the uptake and transport of...
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7189761 |
Nitric oxide donor composition and method for treatment of anal disorders
A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders...
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7189758 |
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
A compound of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
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7179791 |
Inhibiting GS-FDH to modulate NO bioactivity
Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of...
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7169768 |
Method of decreasing atherosclerosis and its complications
A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
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7153871 |
Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II:
wherein R 1 , R 2 , R 3 , R 4 ,...
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7148240 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
The invention relates to benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes...
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7129270 |
Nonsteroidal antiinflammatory agents
Compounds of Formula 1
are useful in the treatment of inflammation.
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7115252 |
Therapeutic compositions and methods of use thereof
A method and composition for the restoration and maintenance of gingival and periodontal health are provided. The composition includes a potassium as an essential ingredient, which acts as an...
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7101912 |
Carbidopa prodrugs and derivatives, and compositions and uses thereof
Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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6964784 |
METHOD OF PREPARATION AND COMPOSITION OF A WATER SOLUBLE EXTRACT OF THE BIOACTIVE COMPONENT OF THE PLANT SPECIES UNCARIA FOR ENHANCING IMMUNE, ANTI-INFLAMMATORY, ANTI-TUMOR AND DNA REPAIR PROCESSES OF WARM BLOODED ANIMALS
A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii)...
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6903134 |
Formulation comprising benzofuranone derivatives for protection against oxidative stress
The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of...
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6878745 |
Selective preventives/remedies for progressive lesions after organ damage
Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the...
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6858632 |
Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance
Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)
in which...
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6828341 |
Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
Described are cyclohexylamine derivatives of Formula I and pharmaceutically acceptable salts thereof, wherein R 1 , g, *, R, V, B, E, Y, G, H, X 1 , and d are as defined in the description. The...
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6784177 |
Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension, and improving oxygen consumption, quality...
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6713506 |
Tea polyphenol esters and analogs thereof for cancer prevention and treatment
Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6677372 |
N-(3-benzofuranyl)urea-derivatives
N-(3-benzofuranyl)urea-derivatives are prepared by reacting of 3-amino-substituted benzofuranes with appropriate substituted isocyanates or isothiocyanates. The N(3-benzofuranyl)urea-derivatives...
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6670355 |
Method of treating cardiovascular disease
This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with...
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6610687 |
Benzofuranylsulfonates
The invention relates to benzofuranylsulfonates of the general formula (I), their preparation and their use for the treatment of inflammation.
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6610652 |
Microdose therapy
Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve...
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6589970 |
6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
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6573295 |
Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a...
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6548086 |
Pharmaceutical composition comprising extract from plant Cryptolepis buchanani for treating immunodeficiency
Pharmaceutical composition and a method useful for treating immunodeficiency in animals or human beings, said composition comprising effective amount of the extract obtained from any part of plant ...
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6524623 |
Therapeutic compositions and methods of use thereof
A therapeutic composition and a method of using the composition are provided. The composition includes an osmotic agent and an active agent. The osmotic agent improves the delivery of the active...
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