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7618949 |
Drug-eluting stents coated with P2Y12 receptor antagonist compound
The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
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7612047 |
Degradation-resistant mononucleoside phosphate compounds
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7608600 |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention...
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7608599 |
Antiviral phosphoramidates
The invention provides novel nucleoside compounds of formula I wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5 R 6 , R 8a , R 9 and R 10 are as defined herein which are useful for the treatment of...
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7608597 |
Methods and compositions for treating hepatitis C virus
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
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7592326 |
Method for stimulating the immune, inflammatory or neuroprotective response
Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune...
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7589076 |
Substituted aryl piperidinylalkynyladenosines as A2AR agonists
A 2A agonists of formula (I) is provided, wherein R 1 , R 2 , R 4 , R 5 , X, Y, Z, n, p, and q are as described herein.
Also provided are compositions comprising and methods of using compounds...
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7585850 |
Stable and active complexes of adenosine and adenosine phosphates with aminoalcohols for the treatment of pulmonary artery hypertension, cardiac failure and other diseases
The invention is directed to compositions and methods which permit the oral use of adenosine and adenosine phosphates for cardiovascular applications such as pulmonary artery hypertension, cardiac...
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7582616 |
Nucleoside transport inhibitors
Compounds or compositions that are inhibitors and/or ligands of nucleoside transporters; and methods of treating cancer, heart disease and stroke, as well as AIDS and other infectious diseases.
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7576068 |
Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus
This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention...
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7566703 |
Semi-soft C-class immunostimulatory oligonucleotides
The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for...
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7557093 |
Composition for promoting collagen production
The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the...
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7557092 |
Purinergic modulation of smell
Disclosed are compositions and methods for modulating odor sensitivity, as well as screening methods for detecting compounds that modulate odor sensitivity.
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7553823 |
C-pyrazole A2A receptor agonists
2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for...
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7534423 |
Method for inducing an elevated level of adenosine in an individual
This invention concerns a method of inducing an elevated level of adenosine in an individual by administering to said individual an effective amount of either i) recombinant protein CD73 or ii) a...
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7524517 |
Methods and compositions for P2X receptor calcium entry channels and other calcium entry mechanisms
This invention relates generally to a method of increasing cytosolic Ca 2+ levels in mammalian cells comprising contacting P2X receptor Ca 2+ entry channels or any and all other Ca 2+ entry...
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7521432 |
Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
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7517862 |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods...
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7514417 |
A1 adenosine receptor agonists
Disclosed are novel compounds that are partial and full A 1 adenosine receptor agonists having the structure of Formula I:
which are useful for treating various disease states, in particular...
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7468357 |
Nucleosides with anti-hepatitis B virus activity
A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally...
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7462604 |
Hair growth promotor composition
A hair growth promotor which is an ethanol or aqueous ethanol preparation comprising, as active ingredients for a hair growth promotor, (A) at least one compound selected from fatty acids having a...
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7452870 |
Drug-eluting stents coated with P2Y12 receptor antagonist compound
The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
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7439349 |
Method for preparation of large volume batches of poly-ICLC with increased biological potency; therapeutic, clinical and veterinary uses thereof
Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for...
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7435724 |
Degradation-resistant mononucleoside phosphate compounds
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7427606 |
Method to reduce inflammatory response in transplanted tissue
The present invention provides a therapeutic method for treating biological diseases that includes the administration of an effective amount of a suitable antibiotic agent, antifungal agent or...
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7425546 |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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7419965 |
Nucleotide lipid ester derivatives
The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formula
wherein R 1 , R 2 , R 3 , X and Y are defined as described herein and salts...
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7399754 |
N2-quinoline or isoquinoline substituted purine derivatives
Novel compound having the following formula:
wherein W represents a hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or an optionally substituted C...
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7387798 |
Method and composition for resuscitation
The key obstacle for current resuscitation is the acutely limited time window. The major reason for the limited time window is that the brain and spinal cord are extremely vulnerable to...
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7378401 |
Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
The present invention is directed to the systemic administration of Fosfluridine Tidoxil, (5-fluorouridine)-5′-phosphoric acid (3-dodecylmercapto-2-decyloxy)propylester or a salt thereof, for the...
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7378400 |
Method to reduce an inflammatory response from arthritis
The present invention provides a therapeutic method for treating an inflammatory response caused by autoimmune stimulation, comprising the administration to a patient in need thereof of an...
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7368439 |
Dinucleoside poly(borano)phosphate derivatives and uses thereof
The present invention provides dinucleoside boranophosphate derivatives of the general formula I:
wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine...
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7354907 |
Short immunomodulatory oligonucleotides
The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The...
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7348315 |
Methods of treating heart failure with modified ATP, ADP and AMP compounds
Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing...
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7345028 |
Energy-protective composition comprising adenosine phosphates
Compositions comprising inorganic phosphate and the nucleotides adenosine diphosphate and adenosine monophosphate; and their use for neutralizing effects of excess incident energy on the human...
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7341990 |
Methods and uses of leukotriene B4 hydroxylases to treat diseases
Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B 4 (LTB 4 ) in those in need of such treatment using...
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7332479 |
Extracellular NAD+ and cADPR as potent anti-inflammatory agents
A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or...
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7323453 |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds
The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7323451 |
Crystalline and amorphous forms of beta-L-2′-deoxythymidine
Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns,...
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7319093 |
Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives
2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and...
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7304043 |
β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
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7297686 |
Chromium complex with insulin-like activity
A chromium complex for use in treating metabolic disorders, particularly Type 1 and Type 2 diabetes.
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7262176 |
Adenosine A3 receptor agonists
Disclosed are novel compounds that are A 3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia.
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7256183 |
Method for treating or preventing inflammatory diseases
The present invention provides a method of preventing or treating an inflammatory disease, including but not limited to, sinusitis, rhinitis, conjunctivitis, asthma, dermatitis, inflammatory bowel...
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7238529 |
Methods and compositions for treating ocular disorders
The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of...
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7235535 |
Method of enhancing drainage of lacrimal system with purinergic receptor agonists
A method and preparation for enhancing drainage of lacrimal system in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a...
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7223744 |
Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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RE39573 |
Antimutagenic compositions for treatment and prevention of photodamage to skin
A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is...
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7192932 |
Use of immunomodulating agents
Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are...
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