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7622500 |
Antiparasitic agents
The present invention relates to compounds of the formula (I)
and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as...
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7601712 |
Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
A compound represented by formula (I)
wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7589122 |
Method for soybean aphid population suppression and monitoring using aphid- and host-plant-associated semiochemical compositions
Soybean volatile compounds, soybean aphid-induced volatile compounds and soybean aphid sex pheromones are semiochemicals of the invention used to suppress soybean aphid population. Methyl...
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7585891 |
Pesticidal (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxole derivatives
Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where...
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7579371 |
Methods of using [3.2.0] heterocyclic compounds and analogs thereof
Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a...
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7579370 |
Fused heterocycles
This invention provides fused heterocycles having the formula:
in which R 1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or...
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7576122 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular...
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7569605 |
Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
The present invention relates to a method of treating a central nervous system disorder, such as a mood disorder (e.g., major depressive disorder) or an anxiety disorder (e.g., general anxiety...
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7569604 |
Heterocyclic derivatives for modulation of calcium channels
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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7560576 |
Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro
-5-isobenzo-furancarbonitrile,...
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7553834 |
Method for the targeted treatment of depression
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
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7547723 |
Comprehensive pharmacologic therapy for treatment of a dysfunction
The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination...
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7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I)
or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
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7524882 |
PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of...
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7524878 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7521570 |
Medicinal compositions containing 6-hydroxybenzbromarone or salts thereof
To provide highly safe therapeutic or preventive agents for hyperuricemia, more specifically uricosuric agents, which have potent uricosuric effect and do not cause grave hepatic disorder....
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7517908 |
Method for augmenting the effects of serotonin reuptake inhibitors
A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an...
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7507839 |
Therapeutic ion channel blocking agents and methods of use thereof
Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3...
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7498349 |
Biaryl compounds having anti-infective activity
Aromatic compounds exemplified by exhibit antimicrobial activity.
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7488752 |
Thrombin receptor antagonists
Heterocyclic-substituted tricyclics of the formula
or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein z,1 represents an optional double bond,...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7476690 |
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of...
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7470799 |
Dihydrobenzofuran derivatives and uses thereof
Compounds of formula I are provided:
wherein each of R 1 , R 2 , y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of...
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7439374 |
Azabenzofuran substituted thioureas; inhibitors of viral replication
The present invention provides compounds of Formula 1,
wherein the variables Ar, A 1 , A 2 , A 3 , A 4 , R 5 , R 6 , R 7 , V, W, X, and Y are defined herein.
Certain compounds of Formula 1...
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7420069 |
Crystalline composition containing escitalopram
Crystalline particles of escitalopram oxalate with a particle size of at least 40 μm is disclosed. Method for the manufacture of said crystalline particles and pharmaceutical compositions...
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7420068 |
Crystalline composition containing escitalopram
The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01% (w/w) of...
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7420066 |
Benzofuran derivatives useful for treating hyper-proliferative disorders
The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of...
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7420001 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7417158 |
Cationic substituted benzofurans as antimicrobial agents
A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods...
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7405311 |
Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential...
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7396857 |
Therapeutic combinations for the treatment or prevention of depression
Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment...
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7384956 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Anti-constipation composition
An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure...
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7368477 |
Benzofuranyl alkanamine derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 1′ , R 2 , R 3 , R 4 , n, and Ar are as defined, and described in classes and...
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7368476 |
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone...
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7361684 |
Screening of compounds for treatment of atherosclerosis and heart attack
Transgenic animals that do not express functional SR-BI and ApoE develop severe atherosclerosis, by age four weeks in transgenic mice. Moreover, these animals exhibit progressive heart dysfunction...
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7348359 |
Retinoid X receptor modulators
The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to...
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7345068 |
Aromatic amino acid derivatives and medicinal compositions
1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt:
wherein,
R 1 is a hydrogen atom or an amino-protecting group, R 2 is a...
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7323494 |
Compounds and methods
Disclosed is a compound of having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables...
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7323493 |
Solid pharmaceutical composition containing benzofuran derivatives
The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the...
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7312239 |
Medicament for prevention and/or therapy of arterial wall disorder
An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided...
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7291639 |
Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
This invention provides methods of inhibiting plasminogen activator inhibitor-1 (PAI-1) in a mammal, utilizing compounds of the formula:
wherein: A is C or N; B is O, S, N, or CH═CH;
...
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7273886 |
Benzofuran inhibitors of factor VIIa
Compounds of Formula I are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds...
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7273863 |
Benzophenones as inhibitors of reverse transcriptase
The present invention includes benzophenone compounds (I)
which are useful in the treatment of HIV infections.
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7268161 |
Comprehensive pharmacologic therapy for treatment of obesity including cysteine
The comprehensive pharmacologic therapy for treatment of obesity including Cysteine is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or...
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7265152 |
Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections...
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7265151 |
Treatment of neurotic disorders
Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided,...
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7211600 |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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