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8168671 |
Synthesis of thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds and their derivatives and use thereof
Inexpensive and facile methods of preparing fused heterocycles such as thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds, and their derivatives are disclosed. Also disclosed are...
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8133906 |
Method of treating amblyopia
The present invention relates to a method of treating or alleviating the symptoms of amblyopia. It is based on the discovery that repeated administration of a specific drug, which is known to be...
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8124653 |
Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
Disclosed is a composition that includes a tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with phenylketonuria that...
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8114890 |
Anti-constipation composition
An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of...
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8110601 |
Compound, α1 adrenergic receptor antagonistic agent, and composition
A novel compound, a novel α1 adrenergic receptor antagonistic agent, and a novel composition are provided which are capable of exerting a therapeutic effect on treatment of hypertension as well as ...
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8088821 |
Fused cyclic compounds
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug...
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8084493 |
Pharmaceutical composition of peptide drug and enzyme-inhibition compounds
The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of...
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8084492 |
Benzofuran compound and pharmaceutical composition containing the same
The present invention relates to a compound having a leukotriene (particularly leukotriene B4) inhibitory action, and useful for the prophylaxis or treatment of diseases such as allergy, asthma,...
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8080582 |
Derivatives of 8-epiblechnic acid and their effects on down-regulation of endothelin (ETA) receptor mRNA
The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as...
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8071613 |
Anti-constipation composition
An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure...
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7998965 |
Glutamate aggrecanase inhibitors
The present invention relates to modulators of metalloproteinase activity.
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7994171 |
Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and...
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7981929 |
Benzofuran derived HIV protease inhibitors
Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV...
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7977380 |
Inhibitors of plasma kallikrein
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
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7919519 |
S1P receptor modulating compounds and use thereof
The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with...
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7915300 |
Cysteine protease inhibitors
A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo;R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl;R4 is H; orR3 together with R4 and the...
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7893084 |
Viral polymerase inhibitors
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR1, or CR1, wherein R1 is defined herein; represents either a single or a double...
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7884129 |
Composition comprising the alcohol compound isolated from the extract of cucurbitaceae family plant having anti-adipogenic and anti-obesity activity
The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the...
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7875632 |
Selective serotonin receptor inverse agonists as therapeutics for disease
Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods...
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7872044 |
Inhibitors of chymase
The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and...
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7855193 |
S1P receptor modulating compounds and use thereof
The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with...
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7846925 |
Azolidinone-vinyl fused-benzene derivatives
The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases,...
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7834004 |
Sulfonyl-substituted bicyclic compounds as modulators of PPAR
Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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7834054 |
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
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7825158 |
Therapeutic agent for substance dependence
The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such...
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7820154 |
Use of IL-1 antagonists to treat gout
Methods of treating, inhibiting, or ameliorating gout, including chronic acute (refractory) gout, pseudogout, or drug-induced gout, in a human subject in need thereof, comprising administering to a...
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7795242 |
Methods and compositions for immunomodulation
Novel antigens are provided herein. The antigens are associated with recognition of CD1 molecules by T cells. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a...
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7776922 |
Substituted [(phenylethanoyl)amino]benzamides
The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of...
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7754700 |
Composition and methods for alleviating symptoms of neurotoxicity
A composition for alleviating symptoms associated with neurotoxicity. The composition may comprise compounds for preventing glutamate mediated neurotoxicity. The composition may include one or more...
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7745445 |
Compounds and compositions as PPAR modulators
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of...
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7723380 |
Antiviral protease inhibitors
The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic...
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7714023 |
Treatment or prophylaxis of migraine or headache disorders using citalopram, escitalopram or citalopram metabolites
Methods for prophylaxis of or treating or preventing migraine or migraine headaches, or other headache disorders include administering to a subject in need of treatment a therapeutically effective...
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7700620 |
C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the...
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7687540 |
Substituted propane phosphinic acid esters
The present invention relates to certain esters of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1 and R2 are as defined herein. The compounds of this invention...
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7683088 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by...
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7662824 |
Acylhydrazones as kinase modulators
The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly...
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7655681 |
Method of treating and diagnosing sleep disordered breathing and means for carrying out the method
A method of treating or preventing Obstructive Sleep Apnea (OSA) comprises the administration of a pharmacologically effective amount of zonisamide to a patient in need thereof, with the proviso...
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7632861 |
Substituted heterocyclic ethers and their use in CNS disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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7625944 |
Inhibitors of plasma kallikrein
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
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7622500 |
Antiparasitic agents
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic...
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7601712 |
Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor...
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7589122 |
Method for soybean aphid population suppression and monitoring using aphid- and host-plant-associated semiochemical compositions
Soybean volatile compounds, soybean aphid-induced volatile compounds and soybean aphid sex pheromones are semiochemicals of the invention used to suppress soybean aphid population. Methyl...
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7585891 |
Pesticidal (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxole derivatives
Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where...
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7579370 |
Fused heterocycles
This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or...
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7576122 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular...
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7569605 |
Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
The present invention relates to a method of treating a central nervous system disorder, such as a mood disorder (e.g., major depressive disorder) or an anxiety disorder (e.g., general anxiety...
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7569604 |
Heterocyclic derivatives for modulation of calcium channels
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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7553834 |
Method for the targeted treatment of depression
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
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7547723 |
Comprehensive pharmacologic therapy for treatment of a dysfunction
The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination...
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7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment...
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