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5684031 |
Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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5684041 |
Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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5684002 |
Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R'; (b) X and X' are independently O or S; (c) each Y is independently hydrogen or straight, branched or...
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5674876 |
ρ-heteroatom-substituted phenols and uses thereof
The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having the structure formula ##STR1## wherein m is 0 to 3, n is 0 to 4 when Het is nitrogen, wherein R...
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5668180 |
Alkoxyaryl compounds
A compound selected from those of formula (I): ##STR1## in which A, R, Y, R 1 , R 2 and R 3 are as defined in the description, and a medicinal product containing the same useful for treating a...
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5665334 |
Benzofuran derivatives and methods for their use as stabilizers and sunscreens against HIV radiations
Compounds of the general formula I ##STR1## R and R 1 , which can be the same or different, are hydrogen or a C 1 -C 8 straight or branched alkyl group, R 2 is hydrogen or the group OR 4 ,...
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5663203 |
Agents containing prostacyclin derivatives for topical application
The invention relates to a dermal application form of prostacyclin derivatives of Formula I ##STR1## wherein R 1 means hydrogen or alkyl of 1-10 carbon atoms, A is a --CH 2 --CH 2 --,...
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5658904 |
1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5643943 |
Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
Methods for treating vascular inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and...
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5637610 |
Composition containing dioxabicyclo [3.3.0] octane derivative
A food, drink, pharmaceutical, cosmetic composition or food additive comprising a dioxabicyclo[3.3.0]octane derivative represented by the following general formula (I): ##STR1## wherein R 1 , R 2 ,...
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5627205 |
Substituted phenoxyisobutyric acids and esters
New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Z are as...
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5627200 |
β.sub.3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia
This invention relates to methods for treating intestinal motility disorders, intestinal ulcerations, including inflammatory bowel disease, ulcerative colitis, Crohn's disease and proctitis, and...
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5622974 |
α-substituted-3-benzyl-benzofurans
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are α-substituted with ether, thioether amino, cyano or halo that are...
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5622989 |
Amino-benzofuryl-and thienyl-derivatives
6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the...
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5620998 |
N-acyl-N-heterocyclylalkylamino acid compounds and method of use thereof
The invention relates to N-acyl-N-heterocyclylalkylamino acids of the formula ##STR1## wherein Y 1 is O, S or N(R) and R is hydrogen or C 1 -C 7 alkyl; X 1 is --CO-- or --S(O) m -- and the...
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5612368 |
O-arylmethyl-N-(thio)acylhydroxylamines
The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar, X, R 1 and R 2 are as defined in the description and a medicinal product containing the same in order...
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5605896 |
Bicyclic heterocyclic derivatives having α.sub.1 adrenergic and 5HT.sub.1A activities
This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and...
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5604228 |
Substituted guanidines having high binding to the sigma receptor and the use thereof
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and...
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5597809 |
Treatment of optic neuritis
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
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5594028 |
Anti-tumor method and compounds
This invention provides certain sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.
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5589512 |
Method for treating borderline personality disorder with serotonin re-uptake blockers
There is disclosed a method for treating borderline personality disorder in a patient by administering a nontoxic dose of a serotonin re-uptake blocker. Preferably, the serotonin re-uptake blocker...
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5587367 |
Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol
A pharmaceutical or cosmetic composition is disclosed comprising in combination a retinoid and a sterol capable of inhibiting the biosynthesis of cholesterol resulting in a synergistic effect in...
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5583152 |
Method for treating vasospastic cardiovascular diseases heterocyclic amide derivatives
The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts...
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5583128 |
Contraception in female primates without affecting the menstrual cycle
The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those...
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5576321 |
Compounds having effects on serotonin-related systems
A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1 A receptor. The...
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5569669 |
Alkylaminoindane compounds
The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 2 ', R 2 ", R 2 '", R 3 and n are as defined in the description, an optical isomer, and an...
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5565488 |
Oxalylamino-benzofuran- and benzothienyl-derivatives
The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The...
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5565485 |
Biphenyl compounds useful or endothelin antagonists
Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension,...
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5565191 |
Cosmetic and dermatological compositions for the protection against UV radiation containing stilbene derivatives
Stilbene derivatives of formula (I) ##STR1## wherein A, R 1 and R 2 are as defined in the following, are useful for the protection against UV radiation.
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5554641 |
Nonpeptides as tachykinin antagonists
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK 3 antagonists expected to be useful in the treatment of pain,...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5523309 |
Benzofuran pharmaceutical compounds
The present invention provides a compound of formula I ##STR1## wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C...
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5523319 |
Compounds of the benzo-heterocycle family
The present application relates to novel compounds of the benzo-heterocycle family as well as to processes for their preparation and to the intermediate compounds obtained.
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5523321 |
Prostacyclins, their analogs or prostaglandins and thromboxane antagonists for treatment of thrombotic and thromboembolic syndromes
Combination products containing a prostaglandin (PG), prostacyclin (PC) or a prostacyclin analog (PCA) and a thromboxane receptor antagonist (TXAA) are suitable for joint application to thrombotic...
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5510379 |
Sulfonate ACAT inhibitors
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
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5506257 |
Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
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5496853 |
Benzoxa condensed ring compounds, process for producing the same and pharmaceutical composition comprising the same
Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In the...
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5494926 |
2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR 8 (R 8 is H or C...
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5492929 |
Condensed heterocyclic compounds useful for inhibiting acyl-CoA
Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom...
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5491152 |
Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT),...
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5488050 |
Methods and products for treating presbyopia
This invention is directed to treatment for increasing the accommodative ability of the eye, for the purpose of decreasing the severity of clinically evident presbyopia, an age-related loss of...
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5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
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5480645 |
Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular,...
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5480912 |
Method of treating HIV-1 with α-substituted benzenemethanamine derivatives
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
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5478844 |
Method of using aminocoumaran derivatives for treating cerebrovascular diseases
A novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R 1 and R 2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R 3 ,...
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5472978 |
Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents optionally substituted phenyl, naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or indazolyl; Z represents O,...
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5468470 |
Benzofuran derivatives and the use thereof as stabilizers against UV radiations
Compounds of the general formula I ##STR1## wherein R-R 4 are as defined in the description, have stabilizing activity against UV radiation and are useful in cosmetics and dermatology.
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5462965 |
Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases
A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with...
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5459139 |
2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
The synthesis and the biological evaluation of a series of basic ethers of 2-benzyl-3-arylbenzofurans as antitumor agents is described. These compounds bind significantly to the...
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5459161 |
Process for the preparation of substituted benzofuran derivatives
Substituted benzofuran derivatives of the formula (I): ##STR1## wherein one of R 1 and R 2 is hydrogen or halogen and the other is, independently, an amino group or a C 2 -C 4 alkanoyl amino...
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