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7265152 |
Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections...
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7211600 |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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7173061 |
Compounds for imaging alzheimer's disease
The invention provides compounds of formula (I) or a salt thereof, radiolabelled versions thereof, and their use in the diagnosis or in vivo imaging of Amyloid-associated diseases such as...
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7160916 |
Method of increasing bone density or treating osteoporosis
This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula:
A...
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7157491 |
Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents
This invention provides estrogen receptor modulators having the structure
where R 1 –R 5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
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7157489 |
HIV protease inhibitors
Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant...
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7148254 |
2-Phenylbenzofuran derivatives, a process for preparing them, and their use
The present invention relates to 2-phenylbenzofurans of formula (I)
which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for...
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7148240 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
The invention relates to benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes...
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7141604 |
Citalopram for the treatment of elevated blood pressure
The invention relates to the use of citalopram or a pharmaceutically acceptable salt thereof for the preparation of pharmaceutical compositions suitable for the treatment of elevated (high) blood...
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7132445 |
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
There are disclosed compounds of the formula
or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic...
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7129268 |
Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
Novel compounds of the general formula (I),
wherein Ar, R 1 , R 2 , X 1 , X 2 , Y 1 , Y, and Z are as defined in the specification, the use of these compounds as pharmaceutical compositions,...
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7122547 |
Anthranilic acid amides and the use thereof as medicaments
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7105568 |
Compounds for treatment of cardiac arrhythmia and methods of use
The subject invention provides novel compounds for treatment of cardiac arrhythmia and methods of use.
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7101912 |
Carbidopa prodrugs and derivatives, and compositions and uses thereof
Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and...
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7101867 |
Benzofuran derivatives, their production and use
Compounds represented by the formula:
wherein R 1 and R 2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R 1 and R 2 may form, together with the adjacent carbon atom, a...
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7098232 |
Treatment and prevention of gastrointestinal disease using antagonists of partial agonists of 5HT1a receptors
The present invention provides a method for preventing and treating gastrointestinal diseases such as dyspepsia, irritable bowel disease and chemotherapy-associated nausea by administering an...
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7091240 |
Tubulin binding ligands and corresponding prodrug constructs
A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo...
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7087635 |
3-substituted oxindole β3 agonists
The present invention relates to a β3 adrenergic receptor agonist of formula I:
or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and,...
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7071227 |
Antiviral compositions and methods of use
Purified antiviral compounds, pharmaceutical formulations containing the compounds, and methods of use of the compounds are provided. The compositions of the invention are isolated antiviral...
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7049334 |
Enhancement of learning and memory and treatment of amnesia
A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I):
A is H, R, or
...
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7045518 |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention...
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7037932 |
Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors
There is provided a heretoaryloxy 3-substituted propanamine compound of formula (I): wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5...
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7037933 |
Compounds for treatment of cardiac arrhythmia, synthesis, and methods of use
The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns...
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7022733 |
Substituted 2-phenyl benzofurans as estrogenic agents
This invention provides estrogen receptor modulators of formula I, having the structure
wherein
R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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7015246 |
Benzofuran derivatives
The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.
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7008950 |
Benzofurans as suppressors of neurodegeneration
A compound of the formula:
wherein R 1 and R 2 each is H or a hydrocarbon group which may be substituted, or R 1 and R 2 form a 3- to 8-membered carbo or heterocyclic ring which may be...
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7008636 |
2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure
or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance...
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7005448 |
Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
The present invention provides novel compounds, compositions containing the compounds of the invention in a pharmaceutically acceptable excipient and methods for using the compositions for lowering...
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7001924 |
Inhibitors of RNase P proteins as antibacterial compounds
The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The...
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6962929 |
Pentafluorobenzenesulfonamides and analogs
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
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6946483 |
Aminoalkenylbenzoyl-benzofuran or benzothiophene, method for preparing same and compositions containing same
The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicaments, in particular in the treatment of...
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6939865 |
Pharmaceutical dronedarone composition for parenteral administration
A subject-matter of the invention is a pharmaceutical composition for parenteral administration, characterized in that it comprises: dronedarone or one of its pharmaceutically acceptable salts as...
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6933317 |
PGD2 receptor antagonistic pharmaceutical compositions
Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGD 2 receptor:
wherein Y is bicyclic ring; R 1 is optionally substituted...
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6921774 |
Compounds and their use as glycine transport inhibitors
The invention provides novel compounds of the formula I below:
wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine...
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6911469 |
Sulfonamide compounds and pharmaceutical use thereof
A sulfonamide compound of the formula (I):
R 1 —SO 2 NHCO—A—X—R 2 (I)
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6908944 |
Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula I:
It has been surprisingly discovered that the pharmaceutical composition of the...
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6903086 |
Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists
This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I:
wherein G 1 is selected from the group consisting of a, b 1 and b 2 ,...
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6884821 |
Carboxylic acid derivatives and drugs containing the same
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
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6878706 |
Cyanamides useful as reversible inhibitors of cysteine proteases
Compounds according to the following formula (I):
wherein the variables Q and R 1 to R 6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F,...
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6869939 |
Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
The present invention provides aqueous parenteral formulations containing an antiarrhythmic agent, such as amiodarone, and a sulfoalkyl ether cyclodextrin. The liquid formulations are clear,...
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6867218 |
Compounds, their preparation and use
The present invention relates to compounds of the general formula (I)
The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
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6861444 |
Bicyclic compounds
Compounds of the general formula (I):
or a salt thereof, wherein R 1 is hydrogen, hydroxyl or halogen; R 2 is NHSO 2 CH 3 , SO 2 NHCH 3 or the like; R 5 and R 6 each independently is...
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6849649 |
N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally...
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6825185 |
Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective...
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6818666 |
Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them
Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.
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