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7393846 |
Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
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7384947 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula
and its use for the treatment of hyper-proliferative disorders.
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7317115 |
Mandelates salts of substituted tetracyclic tetrahydrofuran derivatives
The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I)
the N-oxide forms and the stereochemically...
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7297691 |
Treatment of sleep disorders with cholinesterase inhibitors
The present invention is concerned with treatment of sleep disorders by administering a cholinesterase inhibitor, and in particular, by administering galantamine or a pharmaceutically acceptable...
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7288543 |
Opioid receptor antagonists
A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3′, E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate,...
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7285571 |
Herbal chemical composition for the treatment of cancer
The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7205335 |
Preparation of cis-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
The present invention concerns a process for preparing each of the 4 individual diastereomers of formula (I) in stereochemically pure form from a single enantiomerically pure precursor. The...
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7198808 |
Process for extracting compounds from plants
The present invention provides a method for selectively extracting acidic and/or non-acidic compounds from natural material such as plant tissue.
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7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
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7186752 |
Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
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7144885 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
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7144881 |
Arylcyclopropylcarboxylic amides as potassium channel openers
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined...
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7138427 |
5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia
The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed
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7094805 |
Total synthesis of merrilactone A
This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides...
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7091239 |
DNA polymerase inhibitors, mikanolide and dihydromikanolide
A method of treating proliferative diseases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of at least one compound selected from the group...
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7087641 |
4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents
The present invention provides a new class of compounds 4β-1″-[{2″-benzoyl substituted}anilino] podophyllotoxin exhibiting anti cancer activity and a process for preparing the same.
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7078434 |
Use of Ginkgo extract
The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing...
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7001924 |
Inhibitors of RNase P proteins as antibacterial compounds
The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The...
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6949574 |
(Oxime)carbamoyl fatty acid amide hydrolase inhibitors
The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical...
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6949510 |
Uses of diterpenoid triepoxides as an anti-proliferative agent
Combinations of diterpenoid triepoxides and anti-proliferative agents are used in a combination therapy to treat hyperproliferative disorders. Anti-proliferative agents of interest include agents...
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6946483 |
Aminoalkenylbenzoyl-benzofuran or benzothiophene, method for preparing same and compositions containing same
The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula:
These compounds are of use as medicaments, in particular in the treatment of...
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6943182 |
Cyclopentabenzofuran derivatives and their use
The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of...
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6939876 |
Prevention of addiction in pain management
The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in...
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6927223 |
Use of serotonin agents for adjunct therapy in the treatment of cancer
The invention provides a method for the treatment of cancer comprising administering a serotonin agent. Also provided is a method for the treatment of cachexia comprising administering a serotonin...
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6921756 |
Inhibitors of β-lactamase
The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
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6919372 |
Sustained release pharmaceutical compositions
The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic...
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6908630 |
Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2
A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone...
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6906099 |
Treatment of addiction and addiction-related behavior using a composition of topiramate
The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of...
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6906092 |
Method of inhibiting matrix metalloproteinases
The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I
More particularly, the...
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6894075 |
4′-demethyl-4′-O-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for the preparation thereof and anti-cancer composition comprising the same
The present invention provides a novel 4′-demethyl-4′-O-substituted-1-deoxypodophyllotoxin derivative, a geometric isomer thereof, a process for the preparation thereof, and an anticancer...
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6890946 |
Use of parthenolide to inhibit cancer
The invention provides a method comprising the use of parthenolide, including its analogs, to treat cancer or conditions characterized by abnormal angiogenesis.
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6887869 |
Mikanolide derivatives, their preparation and therapeutic uses
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general...
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6884791 |
Inhibitors of β-lactamase
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
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6878746 |
Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them
A compound selected from these of formula (I):
wherein:
R 1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl,...
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6835719 |
Pesticidal composition
An environmentally safe pesticidal liquid suspension composition including a mixture of sulfur combined with pyrethrins and/or pyrethroids is provided. The pesticidal composition is effective to...
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6808724 |
Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof
The present invention relates to a novel compound isolated from Artemisia Sylvatica , expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel...
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6800656 |
Tricyclic compounds and method of treating herpes virus
The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. Wherein: X=O, (CH 2 ) m , S,...
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6797693 |
Methods using PTPase inhibitors and insulin
This invention provides methods for utilizing a PTPase inhibiting compounds and one or more insulins in methods for use in control and maintenance of type II diabetes in a mammal, for improving the...
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6794408 |
Drechsleranol derivatives, processes for their preparation and their use
The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism Drechslera australlensis , ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524,...
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6773727 |
Use of gossypol and related terpenes for control of urban and agricultural pests
Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites...
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6770673 |
Therapeutic uses of arglabin in combination with other chemotherapy agents
Compositions and kits containing a first chemotherapeutic agent that includes arglabin or a derivative thereof and a second chemotherapeutic agent are described. The compositions and kits are...
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6762183 |
Active substance combinations having insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
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6759065 |
Extraction method, pharmaceutical composition and a cosmetic composition
A compound is extracted from vegetable material, wherein the vegetable material is reduced and treated with a solvent. According to the invention, the vegetable material is frozen using a liquid...
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6713454 |
Prodrugs of etoposide and etoposide analogs
The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or...
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6710089 |
Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6710075 |
Therapeutic compounds and methods
The present invention provides compounds having a cyclopentabenzofuran core and the use of such compounds in therapy as well as compositions comprising said compounds.
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6693127 |
Pharmaceutical compositions of arglabin and arglabin derivatives
Pharmaceutical compositions containing arglabin and arglabin derivatives are described. The compositions can be in unit dosage form and are useful for the treatment of cancer in humans.
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6677355 |
Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors
Compounds of the formula; are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also...
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