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7629381 |
Use of specific cyklolignans
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said...
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7592337 |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
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RE40901 |
Taxane derivatives and processes for the preparation thereof
A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-β-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by...
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7531695 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
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7521476 |
Aminoacetonitrile derivatives suitable for controlling parasites
The invention relates to compounds of the general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 8′ , R 9 , W, a, b and n have the significances given in claim 1 , and...
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7517907 |
Pharmaceutical/cosmetic compositions comprising a novel RARbeta receptor-activating ligand
Novel ligand compounds having the structural formula (I):
and the salts and optical/geometrical isomers thereof are suited for formulation into pharmaceutical compositions useful in human or...
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7423164 |
Synthesis of ionic liquids
Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic liqand with the salt of a metal cation and its conjugate anion. The liquids are...
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7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily...
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7384947 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula
and its use for the treatment of hyper-proliferative disorders.
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7348358 |
Use of cyclolignans
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said...
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7264822 |
Conjugated drug-polymer coated stent
One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one...
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7241805 |
Modified release formulations of a bupropion salt
The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of...
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7211570 |
Treatment of EBV and KHSV infection
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
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7176236 |
Water-soluble etoposide analogs and methods of use thereof
Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-n
itroanilino)-4-desoxy-podophyllotoxin (8) and...
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7144885 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
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7115659 |
Method of treating a condition by administering a prostaglandin derivative
2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified α-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a...
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7098188 |
Anticonvulsant derivative salts
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the...
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7094805 |
Total synthesis of merrilactone A
This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides...
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7087641 |
4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents
The present invention provides a new class of compounds 4β-1″-[{2″-benzoyl substituted}anilino] podophyllotoxin exhibiting anti cancer activity and a process for preparing the same.
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7074837 |
Processes for preparation of bicyclic compounds and intermediates therefor
A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or...
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7041650 |
Anticonvulsant derivative salts
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the...
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7041318 |
Milling process for the production of finely milled medicinal substances
The present invention is a method of milling materials to form a fine powder with a median particle size below 10 micrometer which is suitable for inhalation and which has substantially no...
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6974801 |
Inhibitors and methods of use thereof
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them,...
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6964968 |
Method for the treatment or prevention of viral infection using nucleoside analogues
Viral infections selected from the group consisting of herpes simplex virus, varicella zoster virus, respiratory syncytial virus and cytomegalovirus can be treated by administering to the host a...
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6906101 |
Taxane derivatives and processes for the preparation thereof
A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-β-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by...
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6906099 |
Treatment of addiction and addiction-related behavior using a composition of topiramate
The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of...
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6903133 |
Anticancer compounds
This invention features compounds having formula (I):
wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , T, X, and Y are as defined herein. This invention also features a method for treating...
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6894075 |
4′-demethyl-4′-O-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for the preparation thereof and anti-cancer composition comprising the same
The present invention provides a novel 4′-demethyl-4′-O-substituted-1-deoxypodophyllotoxin derivative, a geometric isomer thereof, a process for the preparation thereof, and an anticancer...
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6878706 |
Cyanamides useful as reversible inhibitors of cysteine proteases
Compounds according to the following formula (I):
wherein the variables Q and R 1 to R 6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F,...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6660728 |
Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
The present invention relates to thienyl substituted acylguanidine derivatives, such as compounds of formula (I) in which R 1 , R 2 , R 4 , R 6 , A, B and D have the meanings indicated in the...
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6653322 |
Therapeutic combinations of RAR antagonists and RXR agonists and use thereof
The present invention provides compositions and methods for treating an animal, preferably a human, suffering from or predisposed to a physical disorder by administering an effective amount of a...
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6653344 |
Pharmaceutical preparations containing a dibenzocyclooctane lignan derivative for treatment of neurodegenerative disease
The present invention relates to the use of a dibenzocyclooctane lignan derivative of the following general formula (I) for treatment of neurodegenerative disorders: wherein R 1 is H or C 1-4 ...
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6649644 |
Method of treating HIV infection by combined use of a cytotoxic agent and a non-nucleoside reverse transcriptase inhibitor
This invention relates to a method of treating human immunodeficiency virus (HIV) infection in a mammal comprising administering to the mammal a therapeutically effective amount of a combination...
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6624154 |
Compositions and methods for treatment of hyperproliferative diseases
The invention relates to compositions comprising a retinoid X receptor agonist and an agent capable of activating protein kinase A. The invention also relates to methods of treating...
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6583172 |
Anticonvulsant derivatives useful in treating chronic neurodegenerative disorders
Anticonvulsant derivatives useful in treating chronic neurodegenerative conditions are disclosed.
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6515029 |
Absorbent article having a hydrophilic lotionized bodyside liner
An absorbent article having a bodyside liner includes a hydrophilic lotion formulation on the outer bodyfacing surface thereof. The hydrophilic lotion formulation comprises from about 10 to about...
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6511681 |
Aqueous solubility pharmaceutical formulations
A formulation of a sparingly water-soluble, crystalline pharmaceutically active agent wherein the active agent is converted to and stabilized in its amorphous form as a solid solution of a normally...
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6495523 |
Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration
Anticonvulsant compounds of the general formula I: where X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as...
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6469060 |
Compositions based on iodopropynyl-and formaldehyde donor compounds and to their use as preservatives
Compositions having broad effectiveness against bacterial and fungi, which comprise (a) an iodopropynylbutyl compound and (b) one or more formaldehyde donor compounds, the formaldehyde donor...
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6462076 |
Beta-amino acid nitrile derivatives as cathepsin K inhibitors
The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease...
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6420377 |
Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: T I —L—T II (I) wherein: T I ...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6410567 |
Pesticide containing a photosensitizer and an attractant
The present invention relates to a new pesticide which is based on a photosensitizer or combination of photosensitizers of the tetrapyrrole and/or tetraazapyrrole series which may comprise a...
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6395772 |
Method for blocking endothelial cell-leukocyte attachment by inhibiting expression of adhesion molecules on the vascular endothelium for therapeutic applications
A method for blocking the attachment of leukocytes to endothelial cells/lining of the blood vessels using a plant derived protoberberine alkaloid, berberine or its pharmaceutically acceptable...
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6369099 |
Method of locking 1 α-OH of vitamin D compounds in axial orientation
A method of modifying or altering the structure of a 1α-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a...
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6362222 |
Analgesic use of podophyllotoxin for treating pain conditions in female genital organs
A method of treating a disease condition intermediated by a center of stimuli which regulates autonomic activity of an internal organ involves administration of an effective amount of podophyllotoxin.
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6355679 |
Preservative compositions based on iodopropynl- and formaldehyde donor compounds
Compositions having broad effectiveness against bacteria and fungi, which comprise (a) an iodopropynylbutyl compound and (b) one or more formaldehyde donor compounds, the formaldehyde donor...
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6353014 |
15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
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