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7544668 |
Saponins derived from Ilex pubescens and method of purifying the same
Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens . The chemical structures and some properties of the triterpene saponin...
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7528167 |
Inhibitors of papilloma virus
A compound of formula (I) or its enantiomers or diastereoisomers thereof:
wherein: A, X, W, R 1 , Y; R 3 ; and R 4 are as defined herein.
The compounds of the invention may be used as...
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7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily...
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7371778 |
Spiro and dispiro 1,2,4-trioxolane antimalarials
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one...
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7354936 |
2-phenylpyran-4-one derivatives
The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula
processes for their preparation, pharmaceutical compositions containing them, and their medical...
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7297691 |
Treatment of sleep disorders with cholinesterase inhibitors
The present invention is concerned with treatment of sleep disorders by administering a cholinesterase inhibitor, and in particular, by administering galantamine or a pharmaceutically acceptable...
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7276533 |
Compositions useful for the treatment of pathologies responding to the activation of PPAR-gamma receptor
This invention features the use of the spirolaxine of formula (I) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the Type 2 insulin-resistant...
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7244750 |
Active substance combinations having insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
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7241741 |
Methods and compositions for the treatment of asthma and related disorders
The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual...
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7232845 |
Active substance combinations comprising insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
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7205289 |
Combinations of active ingredients with insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
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7141603 |
Antitumor agents
The present invention provides compounds of general formula I or II:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have any of the values defined in the specification, and...
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7098225 |
Active compound combinations having insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
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6992093 |
Method of inhibiting lipofibroblast to myofibroblast transdifferentiation
Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.
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6977270 |
Tocotrienolquinone cyclization product with an anti-hypercholesterol effect
A description is given of the use of at least one compound of the formula I
where
R 1 , R 2 , R 3 and R 4 independently of one another are H or C 1 -C 6 -alkyl; and the use of a compound of...
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6962938 |
Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE)
The present application describes novel spiro-cyclic β-amino acid derivatives of formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or...
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6933261 |
2,4,5-Trisubstituted phenylketoenols
The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I)
in which
Het represents one of the groups
wherein A, B, D, G, X, Y and Z have the meaning given...
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6908918 |
Antitumor agents
The present invention provides compounds of general formula I or II:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have any of the values defined in the specification, and...
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6894074 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I)
in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above
and agonists and/or antagonists...
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6893651 |
Active ingredient combinations having insecticidal and acaricidal properties
The invention relates to insecticidal and acaricidal mixtures comprising certain cyclic ketoenols and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against...
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6863902 |
Immediate release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6861391 |
Trifluoromethyl-substituted spirocyclic ketoenols
Trifluoromethyl-substituted spirocyclic ketoenols of the formula (I) are provided
wherein
Het represents one of the groups
and G, V, W, X, Y, and Z are as defined in the specification....
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6846837 |
Topical administration of basic antifungal compositions to treat fungal infections of the nails
Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a...
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6825230 |
Spiro and dispiro 1,2,4-trixolane antimalarials
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one...
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6808724 |
Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof
The present invention relates to a novel compound isolated from Artemisia Sylvatica , expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel...
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6746990 |
2-phenyl-substituted heterocyclic 1,3-ketoenols as herbicides and pesticides
The present invention relates to new compounds of the formula (I): in which X, Y and Z have the meanings given in the description and Het represents one of the groups: in which A, B, D and G...
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6716874 |
Synergistic insecticide mixtures
The invention relates to insecticidal mixtures comprising compounds of the formula (I) in which X′, Y′, Z′, n, G′, A′ and B′ are as defined above and agonists and/or antagonists of...
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6689808 |
Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them
The invention relates to compounds of formula (I): wherein R 1 represents alkyl or ureido, R 2 represents alkyl or hydrogen, or R 1 and R 2 together form a 5- or 6-membered ring, R 3 ...
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6686389 |
2,3-dihydrobenzofuran derivatives
2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R 1 represents a hydrogen atom or an acyl group; R 2 , R 3 and R 4 represent a hydrogen atom, a lower alkyl group or a lower...
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6592902 |
Controlled release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6589976 |
Utilizing spirocyclic phenyl keto-enols as pesticides and herbicides
The invention relates to novel spirocyclic phenylketoenols of the formula in which Het represents one of the groups in which Q represents and X, Y, Z, m, n, R 6 , R 9 , R 10 and R 11 are...
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6559186 |
Compositions and methods of treatment of sympathetically maintained pain
Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other...
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6555566 |
Methods and materials for treating and preventing inflammation of mucosal tissue
The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it...
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6514996 |
Derivatives of benzofuran or benzodioxole
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
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6440999 |
Intimal thickening inhibitory agent
An intimal thickening inhibitory agent comprising, as an active ingredient, a compound represented by formula (1): wherein x represents an oxygen atom or a group of formula (2) —S—(O) n ...
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6436988 |
Use of 3-(2,4,6-trimethylphenyl)-4-neopentylcarbonyloxy-5,5- tetramethylene-&Dgr 3-dihydrofuran-2-one for controlling the white fly
The present application relates to the use of 3-(2,4,6-trimethylphenyl) -4-neopentylcarbonyloxy-5,5-tetramethylene-Δ 3 -dihydrofuran-2-one for controlling insects of the family Aleurodidae (white...
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6417225 |
Prophylactic/therapeutic agents for atherosclerosis
Herein disclosed are prophylactic/therapeutic agents for atherosclerosis containing a compound of general formula (1): wherein R 1 represents a hydrogen atom or an acyl group, R 2 represents a...
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6410590 |
Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable...
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6387948 |
8-Acetylarteminolide and process for preparing same
8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention...
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6380257 |
Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical
The present invention relates to new aromatic di-keto derivatives and to their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents. The derivatives are...
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6376539 |
Substituted bicyclic lactones
The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or...
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6369101 |
Therapeutic method to treat herpes virus infection
A therapeutic method is provided for treating a mammal afflicted with a herpesvirus infection, comprising administering an effective amount of a compound of formula I: wherein R 1 -R 11 , have...
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6310091 |
Fungicidal saponin, CAY-1, and isolation thereof from Capsium species fruit
A novel antifungal compound, "CAY-1", was isolated from the dried fruit of Capsicum frutescens (cayenne pepper), purified to homogeneity, and characterized as a novel sterol glycoside (a saponin)...
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6300370 |
Camomile oils having a high content of natural poly-ynes and process for their preparation
Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.
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6197815 |
Amino acid chelates to reduce still births and increase birth weight in non-human animals
Metal amino acid chelates for animals are beneficial for facilitating and promoting growth by increasing desired metallic ion uptake. The present invention is directed to a process for providing an...
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6153636 |
Fungicidal compositions
A novel fungicidal composition comprising a fungicidally effective amount of a combination consisting of (A) the known aminomethyl heterocycle of the formula ##STR1## and (B) at least one other...
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6121274 |
Dihydrobenzofurane
The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors.
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6060075 |
Check mite composition and a process for preparing the same
This invention relates to a composition for controlling house dust mites. The composition comprises neem seed kernel extract containing azadirachtin, an alcoholic extract of plant resins, plant...
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6054475 |
Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders
Compounds of formula (I) ##STR1## and the salts of these compounds, are efficacious PDE (phosphodiesterase) inhibitors.
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6011058 |
Seco-cholestane derivatives and methods of making the same
The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates...
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