Matches 101 - 150 out of 165 < 1 2 3 4 >
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4870098 Antagonists of leukotriene D.sub.4  
This invention encompasses compounds of Formula I ##STR1## and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: Alk is alkylene or hydroxyalkylene...
4867970 Moistureless oral drug delivery formulation and method for preparing same  
Oral drug delivery systems are provided formed of compositions which include one or more hydrocolloids solids, such as gelatin, pectin, and sodium carboxymethyl cellulose, and preferably mixtures...
4857516 Coumaran derivatives and their pharmaceutical use  
A compound of the formula ##STR1## wherein R is a lower alkyl group, R 0 is hydrogen or an acyl group, R 1 and R 2 are lower alkyl groups which may optionally be substituted or wherein R 1 and...
4855318 Iodopropargyl ethers useful as antimicrobial agents  
Iodopropargyl ethers of the formula ##STR1## wherein A represents oxygen or a methylene group, R 1 denotes hydrogen or lower alkyl, R 2 and R 3 are identical or different and represent...
4851405 Aminomethyl heterocyclic compounds  
Fungicidally effective aminomethyl heterocyclic compounds of the formula ##STR1## in which X represents oxygen or sulphur, R represents hydrogen or alkyl, or represents in each case optionally...
4837211 Spironolactone composition  
A pharmaceutical composition, having utility as a diuretic or aldosterone antagonist, comprising spironolactone and an aqueous homogenizingly effective amount of a material selected from the group...
4831053 Composition for prophylaxis and therapy of hepatitis  
A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or...
4820724 Dual phase solvent carrier system  
A dual phase solvent carrier system for topically applying at least one pharmaceutically active compound comprised of the active compound dissolved in at least one delivery solvent and at least one...
4800202 Aminomethyltetrahydrofurans, fungicidal compositions and use  
Fungicidally active aminomethyltetrahydrofurans of the formula ##STR1## in which A represents a divalent alkylene or alkenylene chain which is in each case optionally substituted and R 1 and R...
4772627 Ground mixture  
A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.
4758561 N-substituted 2-aminomethylene-1,3-indanediones for treating arterial hypertension and spasmodic conditions  
The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R 1 is a hydrogen atom or a lower alkyl group such as...
4757067 Therapeutic application of N-substituted 2-aminomethylene-1,3-indanediones  
The present invention to pharmaceutical composition comprising an effective amount of products having the structural formula ##STR1## where R 1 is a hydrogen atom or a lower alkyl group such as...
4752614 Pharmaceutical compositions of tellerium and selenium compounds for the induction of in vivo and in vitro production of cytokines  
Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment...
4737493 7-((substitu ted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents  
Substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzofuranyl-, and benzo[b]thiofuranylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes are useful as analgesic...
4654209 Preparation for percutaneous administration  
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on...
4623657 Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use  
There are described compounds of the formula ##STR1## where each X is independently H, halogen, loweralkyl, loweralkoxy or OH; m is 1 or 2; and R is --H, O, ##STR2## CH(CH 2 ) n NR 1 CH 3 ,...
4613613 γ-butyrolactone derivatives, process for preparing the same and immunomodulating compositions containing the same as active ingredients  
A γ-butyrolactone derivative represented by the following formula: ##STR1## wherein R 1 represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a phenyl group; R 2...
4591601 Anticonvulsant dioxolane methane sulfamates  
Sulfamates of the following formula (I): ##STR1## wherein R 1 and R 2 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions...
4588591 Analgesic 2-oxa-spirocyclic compounds  
Analgesic 2-oxa-spirocyclic compounds of the formula ##STR1## where the wavy line bonds, p, n, m, A, q, X, Y, R, R 1 , R 2 and E are as defined in the specification, e.g.,...
4576961 Antibiotic heterocyclic oxygen compounds and use  
This invention relates to antibiotic substances, in particular to an antibiotic complex for use in the human and veterinary clinical practice and as an additive in feeds.
4560553 Use of eucalyptol for enhancing skin permeation of bio-affecting agents  
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
4558068 Spirobenzofuranones and their use in treating peptic ulcers  
Novel spirobenzofuranone compounds of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl and --X-- is ##STR2## and a pharmaceutically acceptable salt thereof, have gastric...
4542020 Long-lasting adhesive antifungal suppositories  
Antifungal suppositories are provided which preferably include nystatin as the antifungal agent, together with a hydrocolloid, such as sodium carboxymethylcellulose or hydroxypropylmethylcellulose...
4463013 Oxygen substituted amino-cyclohexyl-benzeneacetamides and -benzamides as water diuretic drugs  
Conditions of inappropriate hyperhydration in warm blooded animals can be treated with an essentially water only diuretic drug compound selected from the group ##STR1## wherein m, n, p, A, E, R, R...
4438130 Analgesic 1-oxa-, aza- and thia-spirocyclic compounds  
Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula ##STR1## wherein p, n, m, A, E, R, R 1 , R 2 , X, Y and Z are as defined in the specification, e.g.,...
4423040 Vehicle composition containing 1-substituted azacyclohexan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
4395416 1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics  
Derivatives of formula: ##STR1## in which Z< represents: either an amino group of struture >N-R 1 where R 1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl...
4371538 Spiro derivatives, process for their preparation and medications containing same  
The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R 1 and...
4361578 D-Homosteroids  
The invention is directed to 3-oxo-D-homosteroids and derivatives thereof which are useful as antiantigens.
4360531 Substituted cycloalkanes  
[2-Amino(substituted cycloaliphatic)]benzeneacetamide and benzamide compounds, e.g., trans-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1,4-dioxas piro[4.5]dec-8 -yl]benzeneacetamide, have useful...
4346101 Benzamide derivative analgesics  
Benzamide derivative analgesic compounds of the formula ##STR1## wherein P, Q, R 1 , R 2 , X and Y are as defined in the specification, e.g.,...
4344934 Therapeutic compositions with enhanced bioavailability  
Novel compositions comprising wetted mixtures of poorly soluble drugs with water soluble polymers useful in increasing bioavailability are disclosed.
4342779 7-Acetylspirobenzofuranone compound  
Novel 7-acetylspirobenzofuranone compound of the formula: ##STR1## has gastric secretion inhibitive, antiinflammatory and analgesic activities, and is of value as drugs.
4330554 Spirobenzofuranone compounds  
Novel spirobenzofuranone compounds of the formula: ##STR1## have gastric secretion inhibitive, antiinflammatory and analgesic activities, and are of value as drugs.
4321257 Potentiated medicaments  
Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal...
4309415 Method and composition for treating inflammatory disorders  
Compositions and use of γ-linolenic acid and related materials with (i) zinc, β-lactam antibiotics or other materials enhancing physiological 1-series PG synthesis and/or (ii) colchicine, Vinca...
4252693 Perfume compositions containing spirane derivatives  
New spirane derivatives useful as odor- and flavor-modifying ingredients for preparing perfumes, perfumed products, for the manufacture of artificial flavors or for flavoring foodstuffs, animal...
4229466 Sesquiterpene derivatives having anti-complementary activity  
A sesquiterpene derivative expressed by the general formula (I): ##STR1## wherein R 1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R 2 and R 3 , which may be the...
4212878 Phenylacetamide derivative analgesics  
N-[(1-Amino-4-(mono or di-oxygen-group-substituted)cyclohex-1-yl)methyl]phenylaceta mide derivatives of the formula 1 ##STR1## wherein R, R 1 , R 2 , R 3 , P, Q, X and Y are defined in the...
4209444 New prostaglandin-like diketals  
Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof, wherein A and D each are ketalized carbonyl groups; B is --CH 2 --,...
4205084 Control of insects with 2-ethyl-1,6-dioxaspiro[4.4]nonane  
The present invention relates to a composition for the control of insects of the order of Pityogenes chalcographus which comprises together with a carrier substance a compound of formula ##STR1##...
4197318 Potentiated antimicrobial medicaments  
Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quaternary ammonium compounds, bisdiguanides, anti-fungal...
4151273 Increasing the absorption rate of insoluble drugs  
The absorption in body fluids of poorly soluble drugs is enhanced by forming a glassy solid matrix of a carrier and the drug. A solution of the drug and the carrier is formed at an elevated...
4120830 Use of spirane derivatives to improve perfume compositions  
Spirane derivatives, most of them are new, useful as odor-modifying ingredients for manufacturing perfumes and perfumed products, and as flavor-modifying ingredients for the manufacture of...
4065573 4-Amino-4-phenylcyclohexanone ketal compositions and process of use  
A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be...
4064263 4,5-Benzospiro(2,4)-heptane (and hepta-4,6-diene)-1-carboxylic acid esters and compositions containing same  
2,2-Dimethyl-4,5-benzospiro(2,4)-heptane-1-carboxylic acid esters and 2,2-dimethyl-4,5-benzospiro(2,4)hepta-4,6-diene-1-carboxylic acid esters of the formula ##STR1## wherein R 1 and R 2 are...
4056625 Pesticidal compositions containing benzodioxole derivatives and methods of combating pests  
Substituted benzodioxoles of the formula: ##STR1## wherein R 1 and R 2 are hydrogen or alkyl of 1 to 6 carbon atoms or together with the linking carbon atom form a cycloalkane or cycloalkene ring...
4039664 Topical griseofulvin composition and method  
There is disclosed a composition and method for topically administering griseofulvin to a human or animal in a manner such that a high degree of epidermal, especially stratum corneum, retention of...
4004022 Spirolactone derivatives  
A compound of the formula ##STR1## wherein R 1 is lower alkyl; R 2 and R 3 are methyl, and R 2 forms cyclo-alkylene of 5 to 6 carbon atoms by combining with R 3 ; M is a substituent...
3972999 Griseofulvin dosage forms  
Completely miscible melt mixes of amorphous griseofulvin and certain polyglycolides or lactic acid modified polyglycolides are described which are formed by melting together griseofulvin and the...
Matches 101 - 150 out of 165 < 1 2 3 4 >