Matches 51 - 100 out of 164 < 1 2 3 4 >
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6011058 Seco-cholestane derivatives and methods of making the same  
The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates...
5998408 Triterpene derivatives with immunosuppressant activity  
The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
5977166 Enhanced flavors using menthone ketals  
A method is disclosed for enhancing flavors in low moisture consumable items, including chewing gum, using menthone ketals. Chewing gum, oral compositions, pharmaceuticals, and low moisture foods...
5977169 Substituted tetronic acids useful for treating HIV and other retroviruses  
This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the...
5907047 Papyracillic acid, method for preparation and its use as synthon for bioactive substances  
This invention relates to a new biologically active compound as shown in formula (I) and its biologically active derivatives; whereas derivatives are produced by the reaction of formula (I) with...
5902587 Camomile oils having a high natural poly-ynes content and process for their production  
Camomile oil having a high cis- and trans-spiroether content is produced in a process which includes steam distillation or aqueous distillation of fresh camomile or an extraction residue of camomile.
5902824 Phenyldihydrobenzofuranes  
Compounds of formula I are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV). They and pharmaceutical compositions in which they are active ingredients are useful...
5882881 Inhibition of cyst formation by cytoskeletal specific drugs  
The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an...
5883120 Antifungal activity of the spongistatins  
This invention relates generally to the field of antifungal agents and a pharmaceutical preparation containing those agents which appear to be potentially useful in the field of antifungal therapy....
5854036 Sesquiteterpenic dervatives  
The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol...
5854235 17-spiromethylene steroids  
The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula: ##STR1## wherein R a and R b are independently selected...
5721233 Derivatives of 2,3-dihydro benzofuranols  
Derivatives of 2,3-dihydro-5-benzofuranol, intermediates thereof, and processes useful for their preparation. These compounds are free radical scavengers and are useful in the treatment of...
5707844 Immunoassay reagents and methods for detecting brequinar and analogs  
The present invention is directed to immunoassay reagents including specific antibodies to quinoline carboxylic acids, such as brequinar; novel quinoline carboxylic acid haptens useful as standards...
5688826 Excitatory amino acid derivatives  
Compounds for formula I ##STR1## in which X represents O, NR a , S, SO or SO 2 and R is as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and...
5684031 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents  
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
5684041 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents  
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
5684002 Dihydorbenzofuran and related compounds useful as anti-inflammatory agents  
A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R'; (b) X and X' are independently O or S; (c) each Y is independently hydrogen or straight, branched or...
5683965 Substituted aryl keto-enolic heterocycles  
The aryl-keto-enolic heterocycles according to the invention have the formula (I), in which Het stands for a heterocyclic group from the series (a), (b) or (c), and X, Y, Z, n, A, B, E, L and M...
5646181 Method and compositions for treating impotence  
Pharmaceutical compositions in topical or parenteral form containing organic nitrites are effective in treating male impotence and erectile dysfunction through topical or intracavernosal...
5637310 Method of treating prostatic adenocarcinoma  
Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-α-reductase inhibiting compound or a combination of steroid 5-α-reductase inhibiting compounds.
5616609 Carcinostatic compound and production thereof  
Described are stelleramacrin A and stelleramacrin B represented by the following formulas (I) and (II), respectively: ##STR1## a process for the preparation thereof; and anticancer agents...
5610122 3-aryl-4-hydroxy-delta3-dihydrofuranone derivatives  
The present invention relates to a new 3-aryl-4-hydroxy-Δ 3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in...
5506257 Aminocyclohexylamides for antiarrhythmic and anaesthetic uses  
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
5489607 Use of enadoline in the treatment of benign prostatic enlargement  
The instant invention is a method of using known compounds, such as (-)-5α,7α,-8β-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4 .5]dec-8-yl]-4-benzofuranacetamide, as agents for treating benign...
5487776 Anti-fungal nail lacquer and method therefor  
An anti-fungal nail lacquer composition containing a film-forming agent, a solvent therefore, and an anti-fungal amount of griseofulvin which can be either in suspension or solution in the nail...
5486537 Topical anti-fungal composition for skin and keratinous tissue  
An antifungal composition which can be topically applied to skin and keratinous tissue and is active against the fungi Trichophyton mentagrophytes and Candida albicans includes griseofulvin...
5444082 3,9-disubstituted-spiro(5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same  
3,9-disubstituted-spiro[5.5]undecanes and ##STR1## wherein, R, Y, A, B and n are defined in the specification, pharmaceutical compositions containing same for the treatment of cardiovascular...
5369105 7-((substituted)amino-8-((substitute d)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders  
Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b]furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as...
5326784 Cycloalkylalkylamines which are sigma-receptor ligands and their application in therapy  
New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R 1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V 1 and V 2...
5300524 Spirocyclic PAF antagonists  
Compounds of general formula I; ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are variables. These compounds are antagonists of platelet activating factor (PAF) and as such are...
5298524 Acidic polycyclic ether antibiotic having an anticoccidial and growth promotant activity  
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic...
5288722 6-amino-6-desoxyfumagillols, production and use thereof  
The present invention relates to a compound of the formula: ##STR1## wherein R 1 is 2-methyl-1-propenyl group or isobutyl group; R 2 and R 3 are each hydrogen atom, an optionally substituted...
5266592 Compositions which have a physiological cooling effect, and active compounds suitable for these compositions  
Ketals, preferably glycerol ketals such as, for example, 1-menthone glycerol ketal or 3,3,5-trimethylcyclohexanone glycerol ketal, have a physiological cooling effect and are therefore suitable as...
5248686 Substituted cyclic amines and pharmaceutical composition containing them  
The invention relates to substituted arylamines and heteroarylamines, their preparation process and the pharmaceutical composition containing them. Said substituted amine is in accordance with the...
5240959 Aranorosinol-A and aranorosinol-B produced by Pseudoarachniotus roseus  
Aranorosinol-A and Aranorosinol-B are compounds of the formula ##STR1## in which R is H (Aranorosinol-A) or CH 2 COCH 3 (Aranorosinol-B); said compounds have antibacterial and antifungal activity.
5225436 Aryl substituted naphthalene derivatives  
Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic...
5223533 New benzylcyclanone derivatives process for preparing them and cosmetic and pharmaceutical compositions containing them  
The invention relates to the benzylcyclanone derivatives of formula: ##STR1## where R 1 and R 3 denote H, OH, linear or branched C 1 -C 8 alkyl or linear or branched C 1 -C 8 alkoxy, R 2 and...
5192798 Lipophilic polyamines useful for treating hypercholesterolemia  
This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto. Z 1 --(CH 2 ) n --Y 1 --X 1 ...
5135746 Control of protozoal disease  
A method for prophylaxis or treatment of protozoal disease which comprises administering to domestic animal a plant component having antiprotozoal activity in combination with an ionophore...
5112858 Antibiotic, aranorosin, a microbiological process for the preparation thereof, and the use thereof as a pharmaceutical  
A new antibiotic, aranorosin, a microbiological process for the preparation thereof, and the use thereof as a pharmaceutical. Aranorosin, a compound of the formula ##STR1## can be prepared with the...
5102908 Method of treating Acquired Immunedeficiency Syndrome (AIDS) using organic tellurium and selenium derivatives  
A method for the treatment of Acquired Immune Deficiency Syndrome is disclosed, which is based on the administration of a tellurium derivative of the formula: ##STR1## wherein Q is Te or Se; t is 1...
5082859 Derivatives of benzocycloalkenyldihydroxyalkanoic acids and medications containing them  
Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromoboxane A 2 receptors and antifungals, denoted by the formula I ##STR1## in which X=CH...
5064856 Novel HMG-CoA synthase inhibitors  
Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##
5039710 Homocyclic derivatives  
Aphidicolane derivatives of the formula: ##STR1## wherein R 1 stands for hydrogen or a hydroxy radical, R 2 stands for a hydroxy or methyl radical, or the group CR 1 R 2 stands for a keto...
5001128 HMG-COA reductase inhibitors  
Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy...
4985421 Fungicidal substituted dioxolanylethylamine  
Fungicidal substituted dioxolanylethylamine of the formula ##STR1## in which R represents alkyl, or represents in each case optionally substituted cycloalkylalkyl, aralkyl, cycloalkyl or aryl, and ...
4971981 Substituted dioxolan and dioxan derivatives useful as pesticides  
Novel substituted 1,3-dioxolan and 1,4-dioxan derivatives of formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each independently of the others represents hydrogen or C 1 -C 4 ...
4962207 Organic derivatives of tellurium and selenium  
The present application discloses novel potassium salts of particular tellurium and selenium compounds which are useful for the stimulation of the production of cytokines.
4873261 Pharmaceutical composition for treating ulcerative large intestinal disease  
A method for treating ulcerative large intestinal diseases with a pharmcautical composition containing, as the active ingredient, a sesquiterpene compound or a salt thereof.
4870098 Antagonists of leukotriene D.sub.4  
This invention encompasses compounds of Formula I ##STR1## and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: Alk is alkylene or hydroxyalkylene...
Matches 51 - 100 out of 164 < 1 2 3 4 >