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7417068 EP4 receptor antagonists  
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R 2 and R 5 is: (i) H or an optionally substituted C 1-4 alkyl group; or (ii)an...
7410999 Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection  
The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure...
7407989 Compounds useful for modulating abnormal cell proliferation  
There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
7405311 Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states  
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential...
7396843 5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors  
Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7393846 Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders  
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
7384962 Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them  
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
7378529 Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
7371777 Cyclic compound and PPAR agonist  
The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester...
7371396 Dermatological and cosmetic compositions  
The present invention relates to a dermatological and/or cosmetic composition comprising a furfuryl derivative of formula (I), and its use in the treatment of dermatological disorders especially...
7368475 Furanose-type bicyclic carbohydrates with biological activity  
The synthesis and study of biological activity of a series of new molecules with potential antimicrobial activity are described. The molecules are bicyclic carbohydrates, based on furanose sugars....
7365089 Triazolo-quinolin derivatives useful as adenosine receptor ligands  
The present invention relates to adenosine A 3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
7361679 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same  
The present invention relates to a 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof, and also relates to a pharmaceutical agent and a VLA-4 and/or LPAM-1 antagonist each of which...
7354604 Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol  
An aqueous disinfecting solution and dry powdered composition which may be dissolved in water to provide the solution. The solution has a pH of from 0.6 to 7 and comprises (a) hydrogen peroxide in...
7335673 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage  
A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts...
7332518 Carboxamides as fungicides in agriculture  
The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R 1 is CH 2 R 2 , CH 2 CH═CHR 2 , CH═C═CHR 2 or...
7317125 Diacylglycerol acyltransferase inhibitors  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
7317039 Deuterated substituted dihydrofuranones and medicaments containing these compounds  
The invention concerns deuterated substituted dihydrofuranones and pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated substituted...
7297714 Inhibitors of cathepsin S  
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
7294641 Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses  
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
7294639 Biaromatic ligand activators of PPARγ receptors  
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited,...
7288567 Inhibitors of histone deacetylase  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
7285571 Herbal chemical composition for the treatment of cancer  
The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer...
7282519 Nitrosated and nitrosylated diuretic compounds, compositions and methods of use  
The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or...
7264822 Conjugated drug-polymer coated stent  
One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one...
7256203 Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents  
A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR 17 , where R 17 is hydrogen or lower alkyl; A and Y are CH, N, NR 17 , O, or S; C 1 and C 2 ...
7244753 Cyclooxygenase-2 selective inhibitors, compositions and methods of use  
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least...
7223791 Function regulator for retinoid relative receptor  
The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula: wherein one of R 1 and R...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
7202247 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders  
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents...
7199148 Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors  
The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
7192940 Ether compounds  
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
7189753 Preemptive prophylaxis of migraine  
A method of preventing the headache phase of migraine in a human comprises administration of a 5HT 1 receptor agonist or administration of an over-the-counter or nonprescription drug to said human...
7186742 Benzamide inhibitors of the P2X7 receptor  
The present invention provides benzamide inhibitors of the P2X 7 receptor of the formula: wherein R 1 –R 3 are as defined herein. The compounds of the invention are useful in the treatment...
7183318 Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them  
The invention concerns compounds of formula (1): R-A-R′ wherein: A is as defined in the description; R represent a group (V), (VI), (VII), or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are...
7183300 Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogues thereof  
Substituted aryl aminomethyl thiazole ureas and analogues thereof that act as inhibitors of viral capsid formation, including HIV capsid formation, are provided here. Generally the virus capsid...
7183297 Biphenyl-derivatives as p38-kinase inhibitors  
Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7160910 Anti-sickling agents  
The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non-toxic, and...
7157458 Bifunctional energy-reversible acyl-compositions  
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
7151118 Biphenylcarboxylic amide derivatives as p38-kinase inhibitors  
Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7144902 Prodrugs of thrombin inhibitors  
The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like...
7144897 Hydroxy alkyl amines  
Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of...
7141246 Lubricious coating  
A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction...
7138414 Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals  
The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives. Compounds are described of the...
7132448 High concentration topical insecticide containing insect growth regulator  
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an...
7129268 Peroxisome proliferator activated receptor-active arylene acetic acid derivatives  
Novel compounds of the general formula (I), wherein Ar, R 1 , R 2 , X 1 , X 2 , Y 1 , Y, and Z are as defined in the specification, the use of these compounds as pharmaceutical compositions,...
7122564 Biaromatic ligand activators of PPARγ receptors  
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited,...
7119085 Methods to treat alzheimer's disease  
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
7115605 Peptide deformylase inhibitors  
PDF inhibitors and novel methods for their use are provided.
7105552 Heterocyclic analogs of diphenylethylene compounds  
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
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