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7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
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7595327 |
Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase
This invention provides compounds of Formula I, having the structure:
that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA),...
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7592467 |
Inhibitors of prolyl endopeptidase
The present invention relates to novel inhibitors of prolyl endopeptidase of formula (1)
wherein I, A, X, Y and Z are specified in the description. The compounds are useful for the treatment of...
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7589121 |
Use of furan alkyls for preparing a drug for treating obesity and cosmetically treating overweight
The invention relates to the use of one or several synthetic or natural furan alkyls for preparing a drug preventing and/or treating obesity or overweight. The use of one or several synthetic or...
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7582677 |
Lignan formulations
A topical formulation which includes a lignan or lignan ester in a dermatologically acceptable vehicle. The formulation can be either a cosmetic formulation or a pharmaceutical formulation.
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7569603 |
Ester compound and its use in pest control
An ester compound represented by the formula (I):
has excellent pest controlling activity and is useful as an active ingredient for a pest controlling agent.
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7569602 |
Furan derivatives as EP4 receptor antagonists
A compound of formula (I):
or a salt, solvate and chemically protected form thereof, wherein one of R 2 and R 5 is: (i) H or an optionally substituted C 1-4 alkyl group; or (ii) an...
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7557247 |
Crystalline form of β2 adrenergic receptor agonist
The invention provides a novel β 2 adrenergic receptor agonist in crystalline salt form. The invention also provides pharmaceutical compositions comprising the novel β 2 adrenergic receptor...
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7553867 |
Furan or thiophene derivative and medicinal use thereof
The present invention provides a compound represented by the formula (I):
[wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or...
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7544667 |
Hypocholesterolemic compounds
The present invention relates to novel hypocholesterolemic compounds of formula (I) useful in the treatment and prevention of atherosclerosis and for the reduction of cholesterol levels as well as...
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7534768 |
Treatment of DNA viral infections
The synergistic combination of a loop diuretic and a cardiac glycoside is useful in the treatment of DNA viral infections.
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7528274 |
Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and...
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7528166 |
Lignan derivatives
Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.
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7517893 |
Bichalcophenes and their prodrugs as antiprotozoal agents
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium...
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7511073 |
Amines that inhibit a mammalian anandamide transporter, and methods of use thereof
One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7495024 |
Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
The method of treating patients be administering phenylalkyl N-hydroxurea derivatives for combating atherosclerotic plaque and cardiovascular diseases and compositions for this use.
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7485752 |
Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7449481 |
Thio-substituted biaryl-methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
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7438900 |
Dendritic encapsulation of active agents
A pharmaceutical composition comprising an active agent bound to a scaffold for dendritic encapsulation wherein said scaffold is covalently or non-covalently attached to a polysaccharide. More...
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7435750 |
Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I:
wherein Ar 1 , Ar 3 , A, B and D are defined herein. The...
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7432289 |
5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors
Compounds of formula (I):
or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7417068 |
EP4 receptor antagonists
A compound of formula (I):
or a salt, solvate and chemically protected form thereof, wherein one of R 2 and R 5 is:
(i) H or an optionally substituted C 1-4 alkyl group; or (ii)an...
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7410999 |
Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure...
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7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
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7405311 |
Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential...
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7396843 |
5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
Compounds of formula (I):
or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7393846 |
Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
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7371777 |
Cyclic compound and PPAR agonist
The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester...
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7371396 |
Dermatological and cosmetic compositions
The present invention relates to a dermatological and/or cosmetic composition comprising a furfuryl derivative of formula (I), and its use in the treatment of dermatological disorders especially...
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7368475 |
Furanose-type bicyclic carbohydrates with biological activity
The synthesis and study of biological activity of a series of new molecules with potential antimicrobial activity are described. The molecules are bicyclic carbohydrates, based on furanose sugars....
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7365089 |
Triazolo-quinolin derivatives useful as adenosine receptor ligands
The present invention relates to adenosine A 3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
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7361679 |
2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same
The present invention relates to a 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof, and also relates to a pharmaceutical agent and a VLA-4 and/or LPAM-1 antagonist each of which...
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7354604 |
Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
An aqueous disinfecting solution and dry powdered composition which may be dissolved in water to provide the solution. The solution has a pH of from 0.6 to 7 and comprises (a) hydrogen peroxide in...
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7354595 |
High concentration dinotefuran formulations
A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the...
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7335673 |
2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts...
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7332518 |
Carboxamides as fungicides in agriculture
The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R 1 is CH 2 R 2 , CH 2 CH═CHR 2 , CH═C═CHR 2 or...
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7317039 |
Deuterated substituted dihydrofuranones and medicaments containing these compounds
The invention concerns deuterated substituted dihydrofuranones and pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated substituted...
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7294641 |
Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
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7294639 |
Biaromatic ligand activators of PPARγ receptors
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I):
and are well suited,...
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7285571 |
Herbal chemical composition for the treatment of cancer
The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer...
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7282519 |
Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated diuretic compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or...
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7264822 |
Conjugated drug-polymer coated stent
One aspect of the invention is a system for treating vascular conditions, including a catheter, a stent coupled to the catheter, and a polymeric coating on the stent comprising at least one...
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7256203 |
Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
A compound of Formula (I):
wherein:
X is selected from the group consisting of O, S, and NR 17 , where R 17 is hydrogen or lower alkyl; A and Y are CH, N, NR 17 , O, or S; C 1 and C 2 ...
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7244753 |
Cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least...
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7223791 |
Function regulator for retinoid relative receptor
The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulating agent comprising a compound represented by the formula:
wherein one of R 1 and R...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7202247 |
1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7199148 |
Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
The present invention concerns the compounds having the formula
N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
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