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9034921 Diphenylmethane derivatives as SGLT2 inhibitors  
A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A...
9029413 Treatment of viral infections by modulation of host cell metabolic pathways  
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets...
8969397 Systems and methods to treat pain locally  
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting...
8969390 Composition containing sorbitan monocaprylate and antimicrobial substances  
The invention relates to liquid compositions which contain a) from 40 to 99.9% by weight of sorbitan monocaprylate and b) from 0.1 to 60% by weight of one or more antimicrobial substances selected...
8927599 Use of statins as anticonvulsants, antiepileptics and neuroprotectors  
The use of statins as antiepileptic, anticonvulsant, neuroprotector and antioxidant compounds, potentially useful for the prevention and/or treatment of epilepsy, epileptic seizures, convulsions,...
8921320 Targeted osmotic lysis of cancer cells  
A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium,...
8877754 Compounds, pharmaceutical compositions and uses thereof  
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
8877715 Cytotoxic conjugates having neuropeptide Y receptor binding compound  
There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition...
8871800 Statin and omega-3 fatty acids for reduction of Apo-B levels  
Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are...
8858994 Pharmaceutical formulation comprising ezetimibe  
The present invention relates to novel formulations comprising ezetimibe as active ingredient. In particular the invention relates to a pharmaceutical composition comprising 5 to 20 wt-%...
8853256 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8853229 Composition containing statins and omega-3 fatty acids  
A combination is described comprising at least one omega-3 fatty acid, optionally esterified or salified, at least one statin, Coenzyme Q10, resveratrol, at least one policosanol, pantethine,...
8828450 Compositions for use against one or more pathogens  
The present invention relates to a composition for use against one or more pathogens, comprising at least one antagonistic micro-organism and at least one salt and/or derivatives thereof as...
8821932 Pharmaceutical compositions  
A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble...
8802718 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8772332 Arylpropionyl-alpha-pyrone antibacterial agents  
The invention provides a compound of formula (I): or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula...
8748483 Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome  
The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
8748484 Organometallic anti-cancer complexes  
An anti-cancer ruthenium complex containing organometallic triruthenium with two maltol ligands is claimed.
8734769 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8729060 Macrocyclic polyoxazole compounds and use thereof  
The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n′ and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as...
8716251 Pharmaceutical formulations containing an SGLT2 inhibitor  
Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical...
8697639 Compositions and methods for treating bacteria  
The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of...
8679534 HMG-CoA reductase inhibitor extended release formulation  
Controlled release oral solid dosage form for the reduction of serum cholesterol levels in humans include a drug comprising an alkyl ester of hydroxy substituted naphthalenes (e.g., lovastatin)...
8673943 Fluorinated derivatives of deferiprone  
The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts...
8623912 Fostriecin derivatives and the pharmaceutical uses thereof  
Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use...
8603989 Method for treating and preventing kidney stones employing an SGLT2 inhibitor and composition containing same  
Methods are provided for treating and/or preventing kidney stones, employing an SGLT2 inhibitor alone, or in combination with a supply of carbohydrate, and/or in combination with a diuretic agent....
8592439 Long-term treatment of symptomatic heart failure  
The main object here is the use of omega-3 polyunsaturated fatty acids (as ethyl esters, hereinafter called “n-3 PUFA”) as a medicament, either alone or in combination with other therapeutic...
8591935 Methods and compositions for treating pain comprising a statin  
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a...
8569362 Polyketide molecules as anticancer agents  
The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as...
8557835 Statin-carboxyalkylether combinations  
The invention is a pharmaceutical composition comprising a carboxyalkylether which lowers triglycerides and elevated HDL, and a statin which inhibits HMG-CoA reductase, thereby reducing LDL, said...
8536222 Addition compounds of guanidinoacetic acid  
The present invention provides new addition compounds of guanidinoacetic acid with malic acid, aspartic acid, ascorbic acid, succinic acid, pyruvic acid, fumaric acid, gluconic acid,...
8529890 Composition for the administration of polymeric drugs  
Provided are improvements in and relating to pharmaceutical compositions for oral administration of polymeric biological drug substances and to methods of treatment using such compositions. In...
8505730 Compositions, kits and regimens for the treatment of skin, especially décolletage  
Compositions, kits and regimens for treatment of damaged skin, especially décolletage, include application of a retinoid, hydroquinone or hydroquinone derivatives, and a composition containing a...
8501759 Use of fibrates  
The present invention, which is applicable in the pharmaceutical industry, relates to the use of fibrates, in particular fenofibrate, especially in the form of a solid oral composition, for the...
8501698 Crystal structures of SGLT2 inhibitors and processes for preparing same  
The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing...
8486374 Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses  
A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said...
8481591 Polymeric topical compositions  
The present invention relates to topical antibacterial compositions. The compositions comprise an antibacterial agent such as mupirocin, water, a polymer and a volatile solvent present in an...
8481570 1-methylnicotinaide derivatives and formulations of treatment of lipoprotein abnormalities  
The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.
8476259 Fasudil in combination therapies for the treatment of pulmonary arterial hypertension  
Preferred embodiments of the present invention are related to novel therapeutic drug combinations and methods for treating and/or preventing pulmonary arterial hypertension and/or stable angina....
8475840 Sustained release formulation for oral administration of HMG-CoA reductase inhibitor and method for the preparation thereof  
The sustained release formulation for oral administration of an HMG-CoA reductase inhibitor of the present invention can be easily and economically prepared and is capable of maintaining a...
8476314 Substance with sedative effect  
A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid in a pharmaceutically acceptable carrier. When administered at a daily dosage...
8414958 Implant and method for the manufacture thereof  
What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The...
8394851 Osmoprotective complexes for prevention of mitochondrial free radical damage related skin aging  
The present invention discloses a method to inhibit a free radical, including a mitochondrial free radical, comprising administering to a subject in need thereof an effective amount of a...
8383651 Compounds which selectively modulate the CB2 receptor  
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
8383614 Hypercholestrolemia and tendinous injuries  
This invention provides compositions and methods of inhibiting, suppressing, or treating a tendinous or musculoskeletal soft tissue injury. The invention further provides a method of ameliorating...
8377918 Apigenin for chemoprevention, and chemotherapy combined with therapeutic reagents  
Apigenin is a nontoxic compound. The present invention is appropriate for apigenin use in people who have a high risk of getting cancer, and in people who have cancer through chemoprevention and...
8372889 Methods for modulating metabolism  
The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention,...
8362086 Long acting injectable formulations  
The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation...
8361972 Pharmaceutical formulations containing an SGLT2 inhibitor  
Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical...
8349888 Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury  
The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention...