Matches 401 - 450 out of 554 < 1 2 3 4 5 6 7 8 9 10 11 12 >
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4937264 Antihypercholesterolemic compounds  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I)...
4933165 Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors  
A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated myopathy is disclosed. The method comprises the adjunct administration of an effective amount of a...
4933364 Process for promoting growth and feed efficiency of food producing mammals  
A process for promoting growth and feed efficiency in food producing mammals is provided by administering to such mammals, growth promoting amounts of a zinc complex of a polyether antibiotic...
4929437 Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors  
A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated elevated transaminase levels is disclosed. The method comprises the adjunct administration of an...
4927851 Analogs of mevalonolactone and derivatives thereof  
Compounds of the formula ##STR1## in which Y is ##STR2## X is O or S; Z is --CHOH--CH 2 --CHOH--CH 2 --COOH, an ester or salt thereof or the lactone thereof; and each of R 1 R 2 and R 3 can...
4920109 Antifungal compositions and method of controlling mycotic infections  
Method of potentiating antifungal agents with 25-azasterol compound to produce superior antifungal compositions and use of the compositions to control mycotic infections is disclosed.
4919921 Compositions for topical use having melanin synthesis-inhibiting activity  
Compositions for topical use having melanin synthesis-inhibiting activity comprising kojic acid or its esters and vitamin C or its derivatives. The compositions have excellent human skin-whitening...
4916155 Crystalline calcium pseudomonate  
Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth...
4914127 3-Demethylmevalonic acid derivatives, a process for their preparation pharmaceutical products based on these compounds, their use and intermediates  
3-Demethylmevalonic acid derivatives of the formula I (δ-lactone) and Ia (corresponding dihydroxycarboxylic acid derivative) ##STR1## in which A-B, Z, R 1 , R 2 , R 3 and R 4 have the indicated...
4908381 Antimicrobial film-forming compositions  
The present invention provides a liquid composition that yields an abrasion resistant polymeric film on a surface that provides extended protection from microbial growth through slow release of a...
4898868 3-demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates  
3-Demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates...
4897382 Organic amide compounds derived from nitrogenous lipids  
Organic amide compounds of the formula ##STR1## wherein R 1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen...
4897397 Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents  
Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
4894391 Novel prostacyclin derivatives, process for the preparation thereof, and use thereof as medicinal agents  
5-Cyanoprostacyclins of Formula I ##STR1## wherein A is a --CH 2 --CH 2 --, trans--CHCH--, or --C.tbd.C-group, W is a free or functionally modified hydroxymethylene group or a free or...
4876280 Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, C 1 -3 alkyl, n-butyl, i-butyl or t-butyl, R 2 is hydrogen or C 1 -3 alkyl, R 3 is hydrogen or C 1 -3 alkyl, R 4 is hydrogen, C...
4876275 3,4-dihydro-2H-pyrans useful as pesticides  
3,4-dihydro-2H-pyrans of the formula I ##STR1## where R 1 is C 4 -C 20 -alkyl, C 4 -C 20 -alkoxyalkyl, aryl or C 7 -C 20 -arylalkyl, or is aryl or C 7 -C 20 -arylalkyl which bears from one...
4871756 Leukotriene antagonists  
Compounds having the formula: ##STR1## are antagonists of leukotrienes of C 4 , D 4 , E 4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic,...
4866090 Novel HMG-CoA reductase inhibitors  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and...
4857546 Novel HMG-CoA reductase inhibitors  
Novel 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and...
4855321 Antihypercholesterolemic compounds  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I)...
4847074 Whitening cosmetic  
A whitening cosmetic comprises kojic acid and cyclodextrins in addition to cosmetic base materials. The kojic acid may be included in cyclodextrins before being incorporated into the cosmetic. The...
4844892 Pheromones  
Compounds of formula ##STR1## in which R represents hydrogen, formyl or an alkanoyl group of two to twenty-five carbon atoms and R' represents an alkyl group of one to thirty-five carbon atoms are...
4839388 Prostacyclins and pharmaceuticals containing the same  
This invention relates to a novel prostacyclin represented by the formula: ##STR1## [wherein R 1 represents --CO 2 R 5 group or --CONR 6 R 7 group; A is (i) --CHCH--CH 2 CH 2 -- or ...
4824829 Non-dusting antibiotic, anticoccidial premix compositions and a process for their manufacture  
The invention provides novel antibiotic, anticoccidial premix compositions which exhibit reduced dusting and lower dermal toxicities and a process for their manufacture.
4824863 Antibiotic A80438  
New polyether antibiotic A80438, its acyl and alkyl ester, alkyl ether and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization...
4822804 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them  
Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI 2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI 2 , ...
4816480 Method for the preparation of feed premix in compositions of maduramicin  
A method for the preparation of feed premix compositions of the antibiotic maduramicin which have improved stability of the antibiotic at elevated temperatures and the stable feed premix...
4814347 Anthelmintic spiroketals and method of use  
This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of...
4812474 Kojic acid ether-ester derivatives  
Kojic acid ether-ester derivatives of formula I ##STR1## are useful pharmacological agents for the prevention, management or alleviation of elastase mediated diseases or conditions.
4804679 Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl )-3,5-dihydroxyhept-6-enoic acids and derivatives thereof  
Compounds of the formula ##STR1## wherein R 1 is C 1 -3 alkyl, and Z is ##STR2## wherein R 7 is hydrogen, R 8 or M, wherein R 8 is a physiologically acceptable and hydrolyzable ester...
4786651 Treatment of cutaneous hyperproliferative dermatoses with manoalide  
Manoalide and its derivatives are useful in the treatment of cutaneous hyperproliferative dermatoses.
4771070 CL-1957A antibiotic compound  
A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties. The antimicrobial compound...
4761426 Lysocellin-containing composition and process for promoting growth and feed efficiency of food producing animals  
A growth promoting and feed efficiency-enhancing amount of a lysocellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts...
4753959 Antibiotic lactone compound  
The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.
4742077 Bicyclic allylether derivatives, processes for their production and their use  
Compounds of formula I ##STR1## wherein R 1 represents a group of formula ##STR2## whereby R 4 and R 5 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy or...
4738982 HMG-CoA reductase inhibitors  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I)...
4725621 CL-1957E antibiotic compound and its production  
A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957E which also exhibits antitumor properties. The antimicrobial compound...
4725302 Substituted phenylhydrazines and phenyloxadiazolinones and pesticidal usage thereof  
Phenylhydrazines of the formula I ##STR1## wherein R 1 is --A--R--Z, A is oxygen, sulfur, ##STR2## R is C 1 -C 6 -alkylene, C 1 -C 6 -haloalkyl-C 1 -C 6 -alkylene, C 1 -C 6 -alkoxy-C 1 ...
4725440 Antifungal pastille formulation and method  
An antifungal pastille formulation, preferably containing nystatin as the antifungal agent, is provided which is soft and smooth in texture and when dissolved slowly in the mouth does not cause...
4725620 2H-pyran-2,6-(3H)-dione derivatives with anti-allergic activity  
Achiral compounds of a 2H-pyran-2,6(3H)-dione derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof, where R is --(CH 2 ) m OH or --CH((CH 2 ) n CH 2 OH) 2 where m is...
4719229 Antihypercholesterolemic agents  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents are represented by the following structural formulae (I) and (II):...
4713393 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4710513 Substituted pyranone inhibitors of cholesterol synthesis  
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit...
4707493 19-epi-dianemycin as an anticoccidial and antibacterial agent  
Antibiotic 19-epi-dianemycin, process for its preparation by fermenting a new strain of Streptomyces hygroscopicus, and isolation from the fermentation broth; and its use as an anticoccidial agent...
4680307 Carbacyclin analogs  
A compound of the formula: ##STR1## wherein X 1 is a free or an esterified carboxyl group, or a group of the formula: ##STR2## (R a and R b are each independently a hydrogen atom, a C 1 -C 4 ...
4673687 New chemotherapeutic agents for the control of plant and animal diseases  
A chemotherapeutic composition for the control of plant diseases caused by mycoplasma-like organisms, rickettsia-like organisms, or seed-borne legume viruses. The composition is composed...
4665092 Styrene derivatives, their use as antiallergic agents and intemediate epoxides for their synthesis  
Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R 1 =H or CH 3 ; R 2 =phenyl, substituted...
4654334 Manganese-containing antibiotic agents  
Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as...
4654363 Synthetic analogs of mevinolin  
Certain 6-(substituted-naphthyl)hydrocarbyl-4-hydroxytetrahydropyran -2-ones are unexpectedly potent in the treatment of familial hypercholesterolemia, hyperlipemia and atherosclerosis by virtue of...
4638002 2,3,4-trinor-1,5-inter-meta-phenylene-prostacyclin compounds useful in inhibiting thrombocyte aggregation  
The invention relates to new 2,3,4-trinor-1,5-inter-m-phenylene-PGI 2 derivatives of the formula (I) ##STR1## wherein A stands for carboxy, cyano, tetrazolyl or --COOR 3 or --CONR 1 R 2 ; R...
Matches 401 - 450 out of 554 < 1 2 3 4 5 6 7 8 9 10 11 12 >