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6071525 |
Whitening cosmetics containing mulberrin
The present invention relates to cosmetic products having a whitening effect, which comprises mulberrin. According to the present invention, an aqueous suspension of the Ramulus mori extract, which...
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6060505 |
Method of treating cancer using C-26 modified bryostatin
Disclosed are modified bryostatins and their use as anticancer drugs.
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6060507 |
Use of massoialactone for inhibition of fungal growth
Massoialactone is useful for preventing or at least inhibiting growth of a fungus. Accordingly, a fungicidal composition has massoialactone as an active antifungal compound together with an...
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6057342 |
Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof,...
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6054478 |
Antifungal sordaridin derivatives
Compounds of the formula (I) ##STR1## and pharmaceutically acceptable salts or metabolically labile derivatives thereof, processes for their preparation, their use as antifungal agents and...
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6040334 |
Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as a modality in cancer therapy
Methods of treating various cancers, such as prostatic adenocarcinoma, with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A), such as lovastatin, are provided. Dosing...
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6040335 |
Therapeutics for thrombocytopenia
Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: ##STR1## (where R is a group --NHCHR 1 R 2 , --N(CHR 1 R 2 ) 2 , --N(CHR 1 R 2 )CHR 3 R 4 , --N +...
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6034073 |
Solvent detergent emulsions having antiviral activity
Methods and pharmaceutical compositions for inactivating an envelope virus using an oil-in-water emulsion including an oil, a surfactant, and an organic phosphate-based solvent are disclosed. These...
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6030951 |
Chrysomycin derivative compounds and use as antitumor agents
Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be...
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6030997 |
Acid labile prodrugs
The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and a blocking group, characterized by the presence of a covalent...
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6030996 |
Mur D inhibiting compounds, compositions containing such compounds and methods of use
The present invention addresses compounds which inhibit Mur D. The compounds are represented by structural formula 1: ##STR1## wherein: X represents OH, OC 1 -6 alkyl, O-aryl, O-Har, uridinyl,...
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6028092 |
Salts of N-(4-Oxo-2-(1H-tetrazoyl-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)b enzamide
This invention relates to novel formulations of salts of certain benzopyran compounds, to compositions containing them and their use in the treatment of certain disorders.
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6025363 |
Composition for suppressing appetite
A method for promoting appetite suppression without promoting anxiety, by administering at least one kavalactone and at least one methylxanthine. The compositions balance the energizing effects of...
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6025389 |
Pharmaceutical and veterinary compositions of mupirocin and methods for their preparation
The invention is directed to a pharmaceutical composition comprising a cream base which comprises mupiricin dihydrate, a mineral oil, one or more fatty alcohols or fatty esters, a polyoxyethylene...
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RE36481 |
HMG-CoA reductase inhibitors
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and...
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6001870 |
Nasopharynx administration of mupirocin for prophylactic treatment of recurrent otitis media
Mupirocin or a salt or ester thereof may be used to treat recurrent sinusitis and recurrent otitis, in particular with novel spray or cream formulations adapted for administration to the nasopharynx.
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5998408 |
Triterpene derivatives with immunosuppressant activity
The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
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5990156 |
6-Carboxamido dihydropyran derivatives
Compounds of formula (I), ##STR1## wherein R 1 represents OR 5 , SR 5 , NR 5 R 6 , N(OR 5 )R 6 or N(NR 5 R 6 )R 6 ; X represents OH, N 3 , NR 3 R 4 or NR 4 CO 2 R 15 ; Y represents H or...
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5977120 |
Composition for achieving an alert, yet calm state
Compositions and a method for promoting an alert state without promoting anxiety, comprising at least one kavalactone and at least one methylxanthine. The compositions balance the energizing...
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5972996 |
4-cyano-4-deformylsordarin derivatives
4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in...
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5972993 |
Composition and method for treating rosacea and sensitive skin with free radical scavengers
A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the...
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5968983 |
Method and formulation for treating vascular disease
A therapeutic mixture comprised of L-arginine and inhibitors of Hmg--CoA-Reductase is disclosed for the treatment of diseases related to endothelial dysfunction, wherein the endothelial dysfunction...
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5965608 |
Xylomollin derivatives for use as insect feeding deterrents
Synthetic derivatives or intermediates of xylomollin are identified which can be used as insect feeding deterrents. The identified derivatives or intermediates exhibiting antifeeding activity...
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5962510 |
Antifungal composition
An aqueous composition is disclosed which comprises 0.1 to 20 g/l of polyene fungicide, 0.5 to 50 g/l of a suitable thickener and optionally 20 to 250 g/l of salt.
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RE36331 |
Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them
Solutions which contain L-carnitine and alkanoyl L-carnitine are useful for stabilizing blood for transfusions.
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5962480 |
Drug for ameliorating brain diseases
The present invention discloses a drug for ameliorating brain diseases which comprises as an active ingredient a compound represented by the following formula (1): ##STR1## or a salt thereof....
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5952376 |
Trienyl compounds
Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.
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5948814 |
Genistein for the treatment of cystic fibrosis
A method of treating cystic fibrosis by generating cystic fibrosis transmembrane conductance regulator (CFTR) function in cells containing mutant CFTR and the therapeutic composition for treatment...
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5948816 |
4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
Compounds represented by general formula (I) and salts thereof useful as non-tolerance-inducing antiviral agents, wherein A is O, CH 2 or S; R 1 is lower alkoxycarbonyl, or the like; R 2 is H,...
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5935996 |
Composition for stimulating osteogenesis and preventingreduction of bone salt
It is an object of this invention to provide a composition capable of being used for foods and pharmaceuticals, which stimulates osteogenesis and has an effect for preventing reduction of a bone...
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5935995 |
Prodrugs for the therapy of tumors and inflammatory disorders
Compounds of the formula I glycosyl-Y --C(Y)--X--! p --W(R) n --Z--C(Y)-active compound (I) are described which are suitable for the...
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5932196 |
Buffered emulsion compositions containing actives subject to acid or base hydrolysis
The present invention are for emulsion compositions and the process for making such compositions containing biological and cosmetic actives subject to hydrolysis of actives during processing and...
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5929101 |
Use of insulin sensitizing agents to treat hypertension
The present invention provides a method for treatin hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.
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5925616 |
Treatment of fungal infections using a combination of an anti-fungal compound and an H-alkyl heterocyclic compound
A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to...
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5919768 |
Di- and trivalent small molecule selectin inhibitors
The present invention provides compounds having structure (II), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.
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5912266 |
Beta.sub.2 integrin cell adhesion molecule inhibitors
This invention concerns compositions and methods utilizing a compound of the formula: ##STR1## for reducing or controlling inflammation and treating pathological conditions mediated by...
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5912019 |
Compounds for reducing ischemia/reperfusion injury
Disclosed herein are compositions containing NO donors, inhibitors of iNOS induction, and endopeptidase inhibitors, and methods for their use for combating injury induced by ischemia and...
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5902805 |
Method for treatment of acne and/or the effects of ageing using HMG-coenzyme A-reductase inhibitor and compositions for performing the same
A method for the treatment of acne and/or the effects of ageing, by administering, to a subject in need thereof, a composition containing an effective amount of at least one HMG-Coenzyme...
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5885992 |
Triterpene derivative and medicinal composition
The invention is composed of a hederagenin derivative of the following formula or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising of this compound as an...
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5876763 |
Glycerol enhanced rehydration formulation
A rehydration formulation which enhances a subjects ability to quickly recover from dehydration. The rehydration formulation includes a glycerol solution combined with a carbohydrate or sodium to...
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5877212 |
Molecular complex and control-release of alpha hydroxyacids
Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release...
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5874103 |
Ionophore antibiotic formulations
An aqueous base suspension concentrate of an ionophore antibiotic or ionophore antibiotics capable of aqueous dilution (if desired) and capable (with or without such aqueous dilution) of being...
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5869523 |
Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin
Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin Process for the manufacture of 6β-(3-substitutedamino) propionyloxy forskolin derivatives of the general...
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5863773 |
Antifungal corynecandin
Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, wherein R is: ##STR2## --C(O)--R 1 wherein R 1 is...
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5863912 |
Method of treatment of hormone-unresponsive metastiatic prostate cancer
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
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5854280 |
Antifungal sordaridin derivatives
A compound of formula ##STR1## wherein Z is a tetrahydro-pyrano group selected from ##STR2## having antifungal activity processes for their preparation and their use in medicines.
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5846966 |
Combinations of hydroxy-substituted azetidinone compounds and HMG CoA Reductase Inhibitors
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar 1 and Ar 2 are aryl or R 4 -substituted aryl; Ar 3 ...
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5840753 |
1,2 diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
The present invention relates to the derivatives of formula: ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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5834473 |
Method for treating coccidiosis
The invention is directed to methods for the treatment of coccidiosis and compositions designed to be administered to animals infected with coccidiosis-inducing organism. The compositions contain...
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5830871 |
Inhibitors of E-, P- and L-selectin binding
Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition...
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