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6432924 |
Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
A composition, device, kit and method for countering or diagnosing cytidine deaminase or deoxycytidine deaminase over-expression or a disorder associated with it, or an increase in number or...
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6407076 |
Adenosine analogues and related method of treatment
A compound of formula (I) wherein R 2 represents C 1-3 alkyl, halogen or hydrogen; R 3 represents a fluorinated straight or branched alkyl group of 1-6 carbon atoms; and salts and solvates...
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6403566 |
Nucleosides having bicyclic sugar moiety
Conformationally restricted 2′, 4′—bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or...
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6403567 |
N-pyrazole A2A adenosine receptor agonists
2-adenosine N-pyrazole compositions having the following formula: and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic...
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6399093 |
Method and composition to treat musculoskeletal disorders
A method and composition for the treatment of musculoskeletal disorders in mammals by the application of a topical composition comprising a permeation enhancing amount of one or more penetration...
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6391859 |
&lsqb 5-Carboxamido or 5-fluoro&rsqb -&lsqb 2′,3′-unsaturated or 3′-modified&rsqb -pyrimidine nucleosides
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6387889 |
Medicinal compositions for treating eye diseases
Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a...
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6379882 |
Method for selecting compounds for treating ischemia-related cellular damage
A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke...
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6372723 |
Compositions and methods for preventing restenosis following revascularization procedures
In the present invention, a method is provided which reduces or prevents restenosis following revascularization procedures. It has now been found that selective stimulation of adenosine A 2A ...
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6358934 |
Anti-retroviral activity of 2′,3′-dideoxy-3′-fluoronucleosides
Use of a compound of the formula wherein Base is thymine, Cytosine, adenine or guanine, or a physiologically acceptable salt thereof, for therapeutic or prophylactic control or treatment of...
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6342484 |
Method and compositions for promotion of wound treatment
The present invention comprises compositions and preparations for the promotion of wound healing in an animal. Methods for preparing the compositions as well as methods for using the compositions...
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6339073 |
Uses of nicotinamide adenine dinucleotide and its derivatives for treatment of malignant and infectious diseases
This invention provides a method of killing tumor cells or microorganisms which comprises contacting the tumor cells or the microorganisms with an amount of nicotinamide adenine dinucleotide (NAD)...
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6333315 |
4'-C-ethynyl purine nucleoside compounds
The invention provides 4'-C-ethynyl purine nucleosides represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of purine and derivatives thereof; X...
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6329349 |
Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid A and adenosine receptor agents
Materials and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises methods of sequential administration of a plurality of...
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6326359 |
Adenosine A2A receptor agonists as antiinflammatory agents
The present invention provides compounds of formula (I): ##STR1## and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions...
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6316423 |
Method of treating ischemic, hypoxic and anoxic brain damage
The present invention provides a method of treating ischemic, hypoxic or anoxic brain damage in an animal comprising administering to an animal afflicted with ischemic, hypoxic, or anoxic brain...
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6294522 |
N6 heterocyclic 8-modified adenosine derivatives
N 6 heterocyclic 8 modified adenosine derivatives that are selective, partial or full adenosine A 1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity,...
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6288113 |
Angiogenesis promoters
An angiogenesis promoter containing a compound of the following formula (I) ##STR1## wherein R 1 is acyl, R 2 is alkyl, R 3 and R 4 are the same or different and each is hydrogen atom or...
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6271212 |
Prodrug azide compositions and compounds
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
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6268351 |
Methods for inducing proliferation in auditory receptor epithelium
The present invention provides novel methods for stimulating proliferation in auditory receptor epithelium. Administration of agents that activate cAMP production result in demonstrable...
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6258794 |
Treatment of mental conditions including depression
The invention provides methods of treating a patient suffering from depression by increasing circulating adenosine levels in the patient. The invention also features diagnostic methods for...
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6258793 |
N6 heterocyclic 5' modified adenosine derivatives
N 6 heterocyclic 5' modified adenosine derivatives that are adenosine A 1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function,...
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6255291 |
Composition and method for treating cancer and immunological disorders resulting in chronic conditions
A composition containing alph-alanine, adenosine compound and a glucan. Methods for treating cancer and immunological disorders with said composition.
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6242429 |
Arabinosyladenine derivatives
Antiviral Ara-A derivatives having resistance to metabolism by adenosinedeaminase (ADA) are 2-substituted arabinosyladenine derivatives represented by the formula (I) and pharmaceutically...
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6242428 |
Nucleoside analogs and uses in treating Plasmodium falciparum infection
The invention relates to novel nucleosides and nucleoside dimers containing an L-sugar in at least one of the nucleosides, and their pharmaceutical compositions.
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6235317 |
Additive for stimulants
An additive for stimulants, useful in particular to reduce the health-damaging effects of coffee beverages, contains one or several vitamins, dandelion root extract, and, if required, one or...
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6232300 |
Treatment of HIV by administration of β-D-2', 3'-didehydro-2',3'-dideoxy-5-fluorocytidine (D4FC)
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6221851 |
Pharmaceutical therapy for congestive heart failure
The present invention is directed to reduce elevated levels of tumor necrosis factor-alpha (TNF-α) found in a failing heart. The present invention is directed to a composition and method of...
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6214807 |
C-pyrazole 2A A receptor agonists
2-adenosine C-pyrazole compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for...
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6194390 |
Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular...
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RE37077 |
Adenosine derivatives and pharmaceutical composition thereof
The present invention relates to novel adenosine derivatives having the formula (I): ##STR1## wherein R is a lower alkyl group; R' is hydrogen or a lower alkyl group; X is a cycloalkyl group, an...
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6194391 |
3'-azido-2',3'-dideoxyuridine administration to treat HIV and related test protocol
It has been discovered that 3'-azido-2',3'-dideoxyuridine (CS-87) induces a transient mutation in HIV-1 at the 70 th codon (K to R, i.e., lysine to arginine) of the reverse transcriptase region of...
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RE37045 |
N-6 substituted-5'-(N-substituted carboxamide)adenosines as cardiac vasodilator and antihypertensive agents
Compounds of the formula ##STR1## are disclosed, wherein R 1 , represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl,...
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6180615 |
Propargyl phenyl ether A2A receptor agonists
2-adenosine propargyl phenyl ether compositions having the following formula: ##STR1## and methods for using the compositions as A 2A receptor agonists to stimulate mammalian coronary...
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6180616 |
Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
A method for the alleviation or normalization (i.e., treatment) of physiopathologically excited sensory nerve function (i.e., pain) comprising the administration of a purine receptor agonist in an...
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6174873 |
Oral administration of adenosine analogs
Disclosed are compositions including an adenosine analog, wherein the composition comprises a dosage form suitable for oral (co)administration. Also disclosed are compositions including adenosine...
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6153594 |
5'-O-acylated antiviral nucleosides
A monoester compound of formula I: Nu--O--Fa wherein O is oxygen, Nu is a nucleoside analog, Fa is an acyl group of a mono-unsaturated C18 or C20 omega-9 fatty acid, which fatty acid is...
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6150337 |
Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes
Ribavirin is employed in a manner which is effective to modulate lymphokine expression in activated T cells. In particular, Ribavirin is used to suppress Type 2-mediated T cell responses and...
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6147056 |
Use of locally applied DNA fragments
Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or...
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6117849 |
S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside complexes as potent inhibitors of HIV-replication
Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of...
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6110902 |
Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
The present invention relates to the treatment of conditions associated with neuronal activity. Specifically, the invention is drawn to methods and compositions for administering adenosine to...
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6110901 |
Method for treating RNA viral infections by using RNA chain terminators
The present invention relates to methods for controlling and/or treating RNA-replicating viral infections which afflict human beings, animals and/or plants. Specifically, the RNA chain terminating...
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6103701 |
Method for enhancing hematopoiesis with acyl deoxyribonucleosides
The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced...
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6103702 |
Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
Methods of treating various-inflammatory conditions, including systemic inflammatory response syndrome (SIRS), septic shock and burns, conditions which may be ameliorated by increased local...
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6096724 |
Pyrimidine derivatives and guanine derivatives, and their use in treating tumor cells
The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring,...
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6093703 |
Pharmaceutical compositions, containing S-adenosyl-L-methionine salt, 5-methyl-tetrahydrofolic acid and 5-formyltetrahydrofolic acid
For the therapy of neurological complications in AIDS sufferers, the use of pharmaceutical compositions containing as an active principle at least one compound selected from the group consisting of...
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6080730 |
Rinse solution for organs and tissues
Disclosed is a rinse solution for rinsing organs and tissues prior to transplantation. The solution comprises, in one liter of solution: from 2 mM to 50 mM glycine; from 0.12 to 1.2 mM adenosine;...
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6068851 |
Formulation for use in the prevention of pathogen induced diseases including HIV and HSV
This invention relates to formulations comprising film-forming components capable of forming per se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly...
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6063805 |
Method for treating hypertension
The present invention relates to a method of treatment of hypertension in a mammal, particularly a human being. This method comprises the administration of a therapeutically effective hypertension...
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6054442 |
Methods and compositions for modulation and inhibition of telomerase in vitro
It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
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