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6670334 |
Method and compositions for treating the inflammatory response
Agonists of A 2A adenosine receptors optionally, in combination with a Type IV phosphodiesterase (PDE) inhibitor are effective for the inhibition of an inflammatory response in mammalian tissue,...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6660721 |
Anti-HCV nucleoside derivatives
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known...
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6656919 |
Method and a product for the rapid decontamination and sterilization of bacterial endospores
The present invention is directed to a method for the disinfection and sterilization of material and surfaces contaminated with one or more members selected from the group consisting of bacteria...
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6653293 |
Methods, apparatuses and medicaments for treating body fluid related diseases
This invention relates to two methods treating such disease as AIDS. The first method includes administering the Trigger Factor such as TNF, which is defined as substance stimulating infected cells...
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6645513 |
Treatment of skin with adenosine or adenosine analog
Methods for enhancing the condition of non-diseased skin by application of compositions containing adenosine or an adenosine analog are disclosed. Also disclosed are methods for increasing DNA...
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6642209 |
Use of adenosine compounds to alleviate or normalize pathologically hyperexcited sensory nerve function in a human patient
A method of inducing anesthesia, sedation, analgesia, hypothermia, and reduced stress by administering an effective amount of an adenosine compound to a mammal. It also provides a method for...
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6642210 |
2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
N-pyrazole substituted 2-adenosine compounds and methods for using the compounds as A 2 A-adenosine receptor agonists useful to stimulate mammalian coronary vasodilation for therapeutic purposes...
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6635615 |
Stable salts of S-adenosyl-l-methionine
Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in...
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6624203 |
Nucleic acid bases used in ophthalmic solutions
An ophthalmic solutions that are broad ranged and effective in low concentrations relative to state of the art systems. In particular it has been found that ophthalmic solutions comprising 0.00001...
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6613345 |
Conjugates of sodium channel blockers and methods of using the same
Compounds of the general formula P 1 -L-P 2 ; wherein “P 1 ” is a pyrazinoylguanidine sodium channel blocker, “L” is a linking group, and “P 2 ” is either (i) a pyrazinoylguanidine...
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6610665 |
2-(purin-9-yl)-tetrahydrofuran-3, 4-diol derivatives
There are disclosed according to the invention, compounds of formula (I) wherein R 1 , R 2 and R 3 are defined in the specification. Additionally, processes of preparing the compounds of formula...
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6605597 |
Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
N 6 heterocyclic 5′ modified adenosine derivatives that are adenosine A 1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte...
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6596701 |
S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
A new paradigm of disease centers around the metabolic pathways of S-adenosyl-L-methionine (SAM), the intermediates of these pathways and other metabolic pathways influenced by the SAM pathways....
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6596700 |
Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described...
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6593307 |
Cyclic-ADP-ribose analogs
The present invention provides a compound of formula I: wherein A, D, R 1 , and R 2 are as defined in the specification; or a salt or a detectably labeled derivative thereof. The invention also...
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6586413 |
Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1...
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6583123 |
Aminosugar, glycosaminoglycan, and S-adenosylmethionine composition for the treatment and repair of connective tissue
A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the...
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6579857 |
Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
The present invention provides materials and methods for the treatment of neoplastic disease states, especially cancers of cells/organs of epithelial origin. For example, the invention provides...
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6576619 |
Orally active A1 adenosine receptor agonists
Esters of N 6 -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivatives having the following formula; wherein the compounds are selective adenosine type 1 receptor agonists that are...
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6576620 |
Method of identifying partial adenosine A1 receptor agonists
The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods...
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6569837 |
β-L-2′-deoxy pyrimidine nucleosides for the treatment of hepatitis B
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
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6566371 |
Intraperitoneal administration of adenosine for the treatment of prevention of gastrointestinal of systemic diseases
A method for preventing or treating gastrointestinal or systemic diseases in a mammalian subject, comprising: the step of administering a therapeutically effective amount of a composition...
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6555545 |
Adenosine A2A receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver
Hepatic cirrhosis and fibrosis and fatty liver can be prevented and treated by administering to a subject in need thereof an effective amount of at least one adenosine A 2A receptor antagonist or...
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6555141 |
L-ergothioneine, Milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage
This invention provides therapeutic compositions for the protection, treatment and repair of liver tissue. The invention relates to novel compositions comprising two or more compounds selected from...
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RE38090 |
3′-substituted nucleoside derivative
The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents...
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6548486 |
Fatty acid esters of nucleoside analogs
New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The...
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6544960 |
Chemical compounds
A compound of formula (I), wherein R 2 represents C 1-3 alkyl, halogen or hydrogen; R 3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R 3 ...
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6537974 |
Method of treating arrhythmias
A method for treating arrhythmia in mammals is provided comprising administering a low dose of an adenosine receptor agonist of the Formula I: wherein R 1 is an optionally substituted...
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6534486 |
2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives
A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a...
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6531457 |
Methods and compositions for treating inflammatory response
Compounds and methods are provided to treat inflammatory conditions with certain A 2A adenosine receptor antagonists.
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6528042 |
Compositions of flavonoids for use as cytoprotectants and methods of making and using them
Non-naturally-occurring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. These compositions comprise a flavonoid or derivative thereof and...
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6528494 |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
There are provided according to the invention novel compounds of formula I wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations...
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6524785 |
Perfusion and/or preservation and/or re-perfusion solution during organ transplant
The invention concerns a perfusion and/or preservation and/or re-perfusion solution during organ transplant, in particular the cardiac organ, containing the following elements: K+ in the range of...
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6511696 |
Infant formula with free amino acids and nucleotides
A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy...
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6506736 |
Method for obtaining and using a combination of a purine nucleotide and nitrogen monoxide donor for treating sexual dysfunction
A method for treating a human being having or suspected of having sexual dysfunction or a disorder of physiological and/or anatomical response to sexual stimulation, said dysfunction or disorder...
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6495521 |
Combination therapy method for treating chronic hepatitis B
The present invention is aimed at augmenting the success rate of using thymosin in treatment of chronic hepatitis B, by employing a combination therapy using thymosin with antiviral agents which...
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6495528 |
2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2...
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6492348 |
Adenosine derivatives
A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable...
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6479466 |
Compositions for treating viral infections, and methods therefor
Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a...
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6475509 |
Covalent conjugates of sodium channel blockers and active compounds
Compounds of the general formula P 1 -L-P 2 ; wherein “P 1 ” is a pyrazinoylguanidine sodium channel blocker, “L” is a linking group, and “P 2 ” is either (i) a pyrazinoylguanidine...
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6458772 |
Prodrugs
Compounds of the formula I or corresponding monohydroxynucleoside derivatives wherein: R 1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon; a C 4 -C 22 ...
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6455507 |
Benzimidazole derivatives
Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of...
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6455510 |
Chemical Compounds
A compound of formula (I) which is an agonist at the adenosine A1 receptor wherein R 2 represents C 1-3 alkyl, halogen or hydrogen; R 3 represents a fluorinated straight or branched alkyl group...
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6448235 |
Method for treating restenosis with A2A adenosine receptor agonists
Agonists of A 2A adenosine receptors in combination with rolipram, its derivatives or other Type IV phosphodiesterase (PDE) inhibitors are effective for the treatment of restenosis.
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6448236 |
Purine derivatives
The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation...
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6440948 |
Thiophene A2A receptor agonists
2-(3-,4-(substituted)-5-alkylthienyl)adenosines and the 5′-uronic acid amide analogues thereof having the following formula: are disclosed herein. Additionally disclosed are medicinal methods...
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6440946 |
Multiple-agents-binding compound, production and use thereof
The present invention is to provide a multiple-agents-binding compound comprising a compound having anti-HIV activity and having no affinity for cell surface protein bound together with a same or...
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6440947 |
Method for treating occlusive peripheral vascular disease and coronary disease
Compositions and methods for treatment of occlusive peripheral vascular disease and coronary disease are disclosed. The compositions and methods allow treatment of diseases associated with...
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6440980 |
Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically...
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