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7053064 |
Compounds for the treatment of tobacco dependence and withdrawal
The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or...
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7049303 |
Inhibition of viruses
Disclosed is a pharmaceutical composition comprising a ribonucleoside analogue in accordance with general formula I or II as herein defined, in admixture with a physiologically acceptable excipient...
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7034011 |
Method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate
It is an object of the present invention to provide a method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate [hereinafter abbreviated...
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7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
The present invention provides compounds having the formula:
wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted...
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7018985 |
Composition and method for inhibiting platelet aggregation
The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method...
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6995148 |
Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor...
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6995145 |
Methods and compositions for modulating drug activity through telomere damage
The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in...
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6987095 |
Fish feed with increased nucleotide content
The present invention provides for the improved uptake of feed additives, pigments for use in coloring the flesh and the like. This improved intestinal uptake of foodstuffs and additives is...
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6979468 |
Oral composition and method for the treatment of inflammatory cutaneous disorders
A method and composition for the treatment of acne vulgaris, acne rosacea, and other inflammatory skin conditions comprises the oral administration of a composition comprising a dose of...
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6974803 |
Pharmaceutical combination
The present invention relates to a combination comprising (a) an adenosine A 2a receptor agonist as defined herein and (b) an adrenergic β2 receptor agonist, for simultaneous, sequential or...
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6949522 |
β-2′- or 3′-halonucleosides
The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or...
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6949521 |
Therapeutic azide compounds
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
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6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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6926911 |
Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The...
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6921754 |
Compositions containing folic acid and reduced folate
Compositions are proposed which comprise folic acid in combination with 5-methyltetrahydrofolic acid, and also compositions which comprise folic acid, 5-methyltetrahydrofolic acid and/or...
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6919320 |
Pharmaceutical compositions containing deoxyribonucleosides for wound healing
The invention relates to compositions comprising 2′-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial...
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6914053 |
Adenosine A3 receptor agonists
Disclosed are novel adenosine A 3 receptor agonists of Formula I:
wherein: R is hydrogen or lower alkyl; R 1 is optionally substituted lower alkoxy or optionally substituted...
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6914061 |
4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z...
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6911435 |
Method of treating leukopenia with adenosine
Adenosine and active agent which interact with the adenosine system are used to treat conditions of weakened, immune system, as an anti-cancer therapy and for improving the therapeutic index of a...
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6903079 |
Nucleoside compounds and compositions thereof
The invention provides a novel class of substituted nucleoside derivatives having the formula:
A-Z1-L-Z2-G
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6900182 |
Inositolphosphoglycan and ribose for treatment of ischaemia-reperfusion injury
Compositions comprising inositolphosphoglycans (IPGs) and ribose are disclosed, and their use in the prevention or treatment of ischaemic-reperfusion injury. This treatment increases the energy...
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6875750 |
Aziridine compounds and methods of making and using them
Aziridine derivatives of formula (I)
are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.
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6833361 |
Nucleosides having bicyclic sugar moiety
Conformationally restricted 2′, 4′-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or linking...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6831072 |
Compositions and methods of synthesis and use of novel nucleic acid structures
The present invention is directed to a method to produce 8-amino-2′deoxyadenosine by treating 8-azido-2′deoxyadenosine with an aqueous solution of methylamine or dimethylamine.
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6800616 |
Treatment of HIV infections
Disclosed is a method of treating an HIV-infected host including administering to the host a therapeutic agent that is cytotoxic or cytostatic with respect to CD4+ T cells, but has reduced...
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6790839 |
Pharmaceutical administration of adenosine agonists
The present invention relates to a method of inducing proliferation of bone marrow cells in a subject, compromising administering to the subject an effective amount of an adenosine A1 receptor...
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6790837 |
Ribavirin syrup formulations
A liquid formulation comprising ribavirin having a longer shelf life and improved taste is disclosed.
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6787526 |
Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described...
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6784166 |
4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication.
The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols...
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6784161 |
Method for the treatment or prevention of flavivirus infections using nucleoside analogues
The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount...
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6784165 |
Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N 6 -substituted-5′(N-substituted)carboxamidoadenosines. More...
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6777396 |
Feed for livestock
A composition for livestock feed, comprising a feed for livestock and at least two additives selected from the group consisting of nucleic acid, glutamine and glutamic acid; and a method for...
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6767544 |
Methods for treating cardiovascular diseases with botulinum toxin
The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood...
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6762170 |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
There are provided according to the invention, novel compounds of formula (I) wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations...
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6759395 |
Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film.
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6753322 |
2-aminocarbonyl-9H-purine derivatives
The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the...
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6740644 |
Chemical compounds
A compound of formula (I), wherein R 2 represents C 1-3 alkyl, halogen or hydrogen; R 3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R 3 ...
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6723737 |
Methods, pharmaceutical and therapeutic compostions for administering adenosine
The invention discloses methods for the chronic administration of adenosine, which contrary to the acute delivery of the drug by injection or infusion, acts in desensitizing adenosine receptors...
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6703376 |
Use of uridine triphosphates and related compounds for the prevention and treatment of pneumonia in immobilized patients
A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises...
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6693088 |
3-deazaadenosine prevents atherosclerosis and graft vasculopathy
Vascular diseases and graft rejection are treated or prevented with 3-deazaadenosine and analogs thereof.
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6689759 |
Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6689761 |
Combination therapy for HIV infection
The combination of the HIV protease inhibitor Compound J, 3TC, and, optionally AZT, ddI, or ddC, is useful in the inhibition of HIV protease, the inhibition of HIV reverse transcriptase, the...
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6680059 |
Vaccines containing ribavirin and methods of use thereof
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
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6680052 |
Methods of inhibiting tumor growth using adenosine receptor activated cells
Methods of treating and/or imaging tumors utilize A 1 adenosine-receptor activated cells (such as monocytes and macrophages) are described. Activated cells may be administered systemically or...
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6680303 |
3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6680292 |
Pharmaceutical composition comprising ribavirin and growth factors and methods of use
The present invention is directed to compositions comprising 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such...
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6677316 |
Adenosine derivatives and methods of administration
A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which...
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6670334 |
Method and compositions for treating the inflammatory response
Agonists of A 2A adenosine receptors optionally, in combination with a Type IV phosphodiesterase (PDE) inhibitor are effective for the inhibition of an inflammatory response in mammalian tissue,...
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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