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7595347 |
Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone...
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7595340 |
Serotonin and norepinephrine reuptake inhibitor and uses thereof
Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a...
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7569601 |
Cycloalkylidene compounds as modulators of estrogen receptor
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective...
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7569576 |
Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof
The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl...
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7566724 |
Glycine derivative and use thereof
The compounds of the disclosure, for example, the compound represented by the formula:
has excellent therapeutic and prophylactic effects against inflammatory bowel disease. Further, they are...
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7557124 |
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
Compounds of Formula I:
(wherein n, R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , Y and Z are as defined herein) which are modulators of chemokine receptor activity and...
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7504434 |
Dimeric compounds and their use as anti-viral agents
The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; R 2 is acetyl or trifluoroacetyl; n and q are either the same or different and selected from...
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7498311 |
Treatment of migraine
A method for treating migraine in non-epileptic subjects which involves administering to subjects an effective amount of a pharmaceutical composition comprising a sulfamate of the following formula:
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7470672 |
Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it...
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7468388 |
Dimeric compounds and their use as anti-viral agents
The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R 2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is...
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7459165 |
Polypeptides of Pseudomonas aeruginosa
The present invention relates to polypeptides of Pseudomonas aeruginosa which may be used to prevent, diagnose and/or treat Pseudomonas aeruginosa infection.
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7432298 |
Fluorescent polymeric materials containing lipid soluble rhodamine dyes
Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored...
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7420002 |
Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such...
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7419967 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7417059 |
Substituted aromatic-ring compounds, process for producing the same and use
The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production,...
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7414074 |
Antiinflammatory lactones
Lactones of Formula (I) which are pharmaceutically active in diseases associated with inflammation
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7396828 |
PI-3 kinase inhibitor prodrugs
The invention provides prodrugs of inhibitors of PI-3 kinase. The compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
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7390803 |
Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
The present invention is directed to compounds of the formula (I) (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 27 , R 28 , R 29 , R 30 , R 31 , X, m, n and the...
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7378399 |
Avermectins substituted in the 4″ and 4′-positions having pesticidal properties
What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH 2 —CH 2 —; n is 0 or 1; R 1 , is C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl or C 2 -C 12 alkenyl; R 2 and R...
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7371772 |
Bicyclic compound, production and use thereof
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is...
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7354936 |
2-phenylpyran-4-one derivatives
The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula
processes for their preparation, pharmaceutical compositions containing them, and their medical...
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7351695 |
Topiramate salts and compositions comprising and methods of making and using the same
The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as...
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7276228 |
Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute...
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7259166 |
Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being...
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7253194 |
Compounds and inhibitors of phospholipases
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is,...
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7226918 |
DNA-PK inhibitors
The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214708 |
Synthetic discodermolide analogs
Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A
where R A through R E and X A are as defined herein.
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7166622 |
Substituted phenylsulfonamide inhibitors of beta amyloid production
Compounds of Formula I,
wherein R 1 –R 8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these...
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7157494 |
Dimeric compounds and their use as anti-viral agents
The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R 2 is acetyl or trifluoroacetyl; X is CONH, SO 2 NH, NHCO or NHCONH; m is either 0 or 1; n is...
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7157489 |
HIV protease inhibitors
Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant...
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7153837 |
Agent for protection of retinal neurons
This invention relates to an agent for the protection of retinal neurons which comprises, as an effective ingredient, sulfamate derivative having the following formula:
and to a method for the...
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7148218 |
Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain substituted polyketides of formula I,
wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7098188 |
Anticonvulsant derivative salts
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the...
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7094803 |
Biologically active raspailamide compounds
The subject invention provides novel compositions of biologically active polyketide compounds that can advantageously be used in blocking cellular proliferation and treatment of cancer.
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7084176 |
N-arylphenylacetamide derivatives and medicinal compositions containing the same
N-Arylphenylacetamide derivatives represented by the following formula [I]:
(wherein R 1 is C 1-6 alkoxy, etc.; R 2 is hydrogen, —(CH 2 ) m —N(R 6 )(R 7 ) (m is an integer of from 1 to...
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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7045535 |
Compounds useful for inhibiting paramyxovirus neuraminidase
Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:
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7041650 |
Anticonvulsant derivative salts
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7018983 |
Treatment of migraine
A method for treating migraine in non-epileptic subjects which involves administering to subjects an effective amount of a pharmaceutical composition comprising a sulfamate of the following formula:
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7012093 |
Multiple fluorescent natural dye compound from a marine organism and method of use thereof
The present invention provides a novel compound multiple fluorescent natural dye from a marine organism Holothuria Scabra having a chemical structure of of Si—O—R type wherein silica matrix...
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6989383 |
Method of treating cancer
The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase,...
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6906085 |
Tetrahydropyran derivatives as neurokinin receptor antagonists
The present invention relates compounds of the formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 represent a variety of substituents; and pharmaceutically acceptable salts...
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6905669 |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer by reestablishing the gene expression through inhibition of DNA...
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6890910 |
Murd protein and gene of Pseudomonas aeruginosa
This invention provides isolated polynucleotides that encode the MurD protein of Pseudomonas aeruginosa . Purified and isolated MurD recombinant proteins are also provided. Nucleic acid sequences...
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