Matches 151 - 200 out of 254 < 1 2 3 4 5 6 >
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5510379 Sulfonate ACAT inhibitors  
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
5506211 Genistein for use in inhibiting osteroclasts  
Disclosed are methods and compositions for use in inhibiting osteoclast activity and, particularly, the osteoclast acid secretion that leads to bone-degradation. It is shown that the isoflavone...
5489585 Alkoxylated phenyl and coumarin derivatives useful in the treatment of viral infections  
Alkoxylated phenyl and coumarin derivatives useful in the treatment of viral infections are disclosed. The compounds are particularly useful in the treatment of picornaviruses, and more...
5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5480907 Aromatic amide compounds and their production and use  
Aromatic amide compounds of the formula: ##STR1## wherein R 1 , R 2 , and R 3 are independently hydrogen, a lower alkyl or lower alkoxy group; Ar is an optionally substituted aromatic group; the...
5478857 Use of PLA.sub.2 inhibitors as treatment for alzheimer's disease  
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of...
5455268 Esculetin derivatives and pharmaceutical composition  
A pharmaceutical composition comprising a compound of the general formula (I): ##STR1## wherein R 1 and R 2 are, independently, a hydrogen atom, a saturated or unsaturated aliphatic acyl having 2...
5444042 Method of treatment of neurodegeneration with calpain inhibitors  
The present invention provides a method of treating a neurodegenerative pathology in a human patient. This method includes selecting a patient for monitoring for the presence of a neurodegenerative...
5428059 Benzopyran derivatives and an anti-allergic agent possessing the same as the active ingredient  
The present invention relates to an extremely effective anti-allergic agent with a low toxicity, which possesses as its active ingredient a benzopyran derivative described by the general formula...
5424320 Heteroaryl coumarins as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5414006 Arylalkoxythiocoumarins, the preparation thereof and therapeutic compositions containing these  
Arylalkoxythiocoumarins of the formula ##STR1## where R 1 and R 2 are each, independently of one another, hydrogen, C 1 -C 5 -alkyl, trifluoromethyl, phenyl or halogen, or together are a C 3 ...
5393729 3-aryl-pyrone derivatives  
The invention relates to 3-aryl-pyrone derivatives of the general formula (I) ##STR1## in which the substituents are as defined in the specification. The compounds are useful as pesticides,...
5393771 4-substituted benzopyran and related compounds  
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds have potassium channel activating activity and are useful, therefore for example, as...
5389646 Methods for treatment and prevention of bone loss using 2,3-benzopyrans  
Methods and pharmaceutical compositions for reducing bone loss are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment...
5376679 Bicyclic or tricyclic biocidal compounds  
Compounds of the general formula ##STR1## where R 2 and R 3 together, or R 3 and R 4 together, represent an optionally substituted hydrocarbyloxy chain; the ring is optionally substituted at...
5348973 Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis  
Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog,...
5317029 Pharmaceutical composition of benzopyranes for the inhibition of bone resorption  
Pharmaceutical compositions for the inhibition of bone resorption comprising a pharmaceutical carrier and a therapeutically effective amount of a benzopyran derivative represented by the general...
5314918 Leukotriene antagonists  
This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, processes for the preparation thereof, and...
5278186 Chromene derivatives, their production and use  
A chromene derivative of the formula (I) ##STR1## wherein each ring of A and B can have one or more substituents; X is an oxygen atom or sulfur atom, Y is an oxygen or sulfur atom or H 2 , Z is a...
5273993 Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals  
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O) 2 NR 1 R 2 ] z wherein A...
5254595 Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them  
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
5252612 Microbial immunosoppressant agent  
Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp....
5250529 Method alleviating migraine headache with mast cell degranulation blocking agents  
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the...
5185366 Method for treatment and prevention of diseases caused by enveloped viruses, including herpes simplex virus types 1 and 2 diseases, using 3,4-dihydroxy-2H-benzopyran-2H-one  
The present invention relates to the pharmaceutical use of 3,4-dihydroxybenzopyranone compounds in the treatment of diseases caused by enveloped viruses, including herpes simplex virus (HSV) types...
5155127 N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents  
Novel N-[substituted aryl]-N'-(substituted alkoxy)-urea and thiourea derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in...
5139940 Activation compounds and methods of synthesis of activation compounds  
The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate...
5132321 Anticoagulant/surfactant rodenticidal compositions and method  
Rodenticidal compositions comprising an anticoagulant type rodenticide in combination with a fluorosurfactant of the amphoteric, anionic or cationic type, optionally admixed with a cereal grain...
5106407 Iodones and methods for antimicrobial use  
The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that...
5100914 Arylalkoxycoumarins  
Arylalkoxycoumarins of the general formula I ##STR1## where R 1 and R 2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an...
5096887 Treatment of high protein oedemas  
A method of applying a drug selected from the benzo-pyrone group of drugs to an animal to treat high-protein oedemas.
5077281 Novel use of taurolin  
Taurolin compounds are used as blood coagulation-inhibiting agents and as abacterial inflammation-inhibiting agents. The outstanding coagulation-inhibiting action of taurolin is especially suitable...
5064861 Acylated amine compounds which are useful fungicigal agents  
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R 1 is selected from the group consisting of Ar-O- and aryl, polyaryl and condensed polyaryl...
5041430 Oral anticoagulant/platelet inhibitor low dose formulation  
There are disclosed combination products useful for the treatment and/or prevention of a first or recurrent myocardial infarction or a first or recurrent stroke. Said combination products comprise...
5010104 Tricyclic compounds  
Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formul (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and...
5006340 Curable compositions for dental drugs having sustained release property  
A crude drug ingredient having bactericidal activity incorporated into a curable composition comprising a (meth)acrylate type monomer, a polymerization initiator and if necessary a filler to...
H000852 Rodenticidal composition  
A method for stabilizing a rodenticidally active material selected from certain (i) indane dione derivatives, (ii) hydroxycoumarin derivatives and (iii) thiocoumarin analogs of (ii), comprising...
4868206 Composition for rodent control  
A composition and a method of using the same wherein said composition comprises a rodenticide and an additive selected from the group consisting of 1. polyoxyalkylated alkyl phenols; 2....
4863949 Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them  
The present invention provides compounds of the general formula: ##STR1## wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic radical, A is a straight-chained or branched...
4845121 Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties  
The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless...
4837222 Xenocoumacins  
The invention relates to compounds of formula (I), some of which are derived from culture of Xenorhabdus nematophilus and Xenorhabdus luminescens. The compounds possess antibacterial, antifungal,...
4829080 Aromatic benzopyranyl and benzopyranyl compounds; their preparation; and their use in cosmetic compositions and human and veterinary medicine  
An aromatic benzopyranyl or benzothiopyranyl compound of the formula ##STR1## wherein n is 0 or 1, X represents ##STR2## R' represents H, OH, acyloxy or NH 2 , R" represents H or alkoxy or R'...
4815923 Sweet corn based rodenticide  
A rodenticide includes an active ingredient mixed with an inert ingredient comprising dried sweet corn as a substantial portion thereof. The dried sweet corn is preferably ground, mixed with the...
4785004 Aromatic thioethers  
Novel asymmetric thioethers of the formula ##STR1## in which the general symbols have the following meanings: R 0 represents hydrogen or C 1 -7 -alkanoyl, R 1 represents C 1 -3 -alkyl which...
4783481 Rodenticides  
Rodenticidal compositions comprising a rodenticidally effective amount of an isomer of a 3-substituted-4-hydroxycoumarin rodenticide which is capable of existing in more than one stable isomeric...
4766144 3-carbamoyl-4-hydroxy-coumarins for combating parasitic heiminths  
3-carbamoyl-4-hydroxy-couramins for combating parasitic helminths of the formula ##STR1## in which R 1 represents hydrogen, halogen, alkyl, NO 2 , CN or alkoxy, X represents O, S, SO or SO 2 ...
4748185 4-hydroxycoumarin derivatives  
The invention provides 4-hydroxycoumarin compounds of general formula ##STR1## wherein R 1 and R 2 are independently selected from hydrogen and halogen atoms and R represents a group of formula...
4737517 Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer  
A compound having the formula: ##STR1## wherein R 1 is halogen or a substituted or unsubstituted hydrocarbon group; R 2 R 6 and R 7 , which may be the same or different, each represents hydrogen...
4665088 (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides  
This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed...
4618622 Sulfonates of hydroxycoumarins  
Sulfonates of hydroxycoumarins of the formula I ##STR1## where R 1 and R 2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by...
4616033 7 hydroxy-coumarin as a treatment for high protein oedemas  
A method of treating high-protein oedemas in humans or animals by administering the compound 7 hydroxy-coumarin.
Matches 151 - 200 out of 254 < 1 2 3 4 5 6 >