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6737439 |
Aromatase inhibitors from Broussonetia papyrifera
A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera , or compounds included therein having aromatase inhibition properties,...
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6727278 |
Pharmaceutically active agents that impede amyloid formation in vivo
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation...
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6713506 |
Tea polyphenol esters and analogs thereof for cancer prevention and treatment
Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal...
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6706757 |
Chroman derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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6696485 |
Procyanidin and cyclo-oxygenase modulator compositions
This invention relates to compositions comprising a cyclo-oxygenase modulator in combination with cocoa procyanidin monomers and/or oligomers, wherein the cyclo-oxygenase modulator is a...
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6696483 |
Inhibitors of angiogenesis and tumor growth for local and systemic administration
The invention provides pharmaceutical formulations and methods for the treatment of individuals suffering from a condition, disease, or disorder that is treatable by the inhibition of angiogenesis....
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6696484 |
Method and compositions for regulation of 5-alpha reductase activity
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids,...
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6680332 |
Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA
Disclosed is a method for treating a disorder responsive to the positive modulation of AMPA receptors in animals suffering therefrom, comprising administering to an animal in need thereof a...
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6670383 |
Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity
The present invention relates to compounds and compositions useful in treating or preventing conditions and diseases related to Mycobacterium infection, and methods of use directed thereto.
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6670391 |
Benzopyran derivative and antiallergic agent
The present invention provides a compound which is highly safe in terms of toxicity and has a stronger antiallergic action, and particularly has an action of inhibiting both immediate and delayed...
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6660767 |
Coumarin compounds as microtubule stabilizing agents and therapeutic uses thereof
Compounds and compositions for stabilizing microtubules are disclosed. Also disclosed are methods of inhibiting, preventing, regulating, modulating, attenuating, stabilizing, or affecting...
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6579902 |
Ribose-substituted aromatic amides, method for the production and use thereof as medicaments
Compounds of formula (I); wherein R 1 =alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R 2 =hydrogen or halogen; R 3 =hydrogen, alkyl or...
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6576660 |
Methods and compositions for regulation of 5-α-reductase activity
Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
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6555332 |
Fluorescent detection method for microorganisms based on nitrocoumarins
A nitrocoumarin compound or one of its derivatives which are fluorescent in the reduced state, and the use of these compounds for detecting the presence or absence of at least one microorganism....
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6552089 |
Method of treating or preventing alopecia
The present application discloses a method of treating alopecia which is based on the use of a tellurium compound such as ammonium trichloro(dioxoethylene-O,O-tellurate).
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6548521 |
Inhibitors of metazoan parasite proteases
Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one...
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6524832 |
DNA damaging agents in combination with tyrosine kinase inhibitors
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
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6512005 |
Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates
An improved procedure for the purification of warfarin acid. Sodium, potassium and lithium warfarin salts and the corresponding clathrates are prepared in high, pharnacopeial grade purity and good...
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6500846 |
CDK inhibitors having flavone structure
The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase...
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6455578 |
Aromatic derivatives and iron complexes thereof for the use as normalizing agents of the iron level
The present invention is directed to aromatic derivatives of formula (I), wherein: R 1 is (a), wherein R 3 and R 4 are selected from between H and OH, provided that R 3 and R 4 are not...
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6455032 |
Composition and method for protecting skin from UV induced immunosuppression and skin damage
Compositions and a method of protecting skin from either UV-induced immunosuppression or from UV-induced skin damage using a composition containing an extract of soy or clover, and/or the...
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6455579 |
Pyran derivatives
Disclosed are pyran derivatives, which have distinctive sensitivity to visible light and distinctive luminous ability. The derivatives are useful in photopolymerization, electroluminescence, and...
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6447809 |
Composition for promoting healthy bone structure
A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline...
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6436987 |
Crystalline forms of (3S-trans)-2-&lsqb 3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl&rsqb -4-(trifluoromethyl)-benzoic acid
The present invention provides novel polymorphic forms of anhydrous crystalline (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-be
nzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid,...
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6426362 |
Formulations of tocopherols and methods of making and using them
Non-naturally-occuring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. The compositions comprise a tocopherol and/or a derivative thereof,...
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6420401 |
1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
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6407073 |
Use of coumarin derivatives for the treatment of digestive tract disorders
A compound of the formula wherein W is H or a β-D-glucopyranoslyloxy group, and Y and Z are independently H, C 1-6 alkyl, or C 1-6 alkoxy or a pharmacologically acceptable derivative thereof,...
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6403638 |
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R 1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid...
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6365199 |
Hair growth stimulant
A hair growth formulation. The two basic main ingredients are castor oil and a special lemon extract. The special lemon extract is made from fresh lemon peel. The peel, including the bioflavonoids...
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6335363 |
Use of inhibitors of the KQTI channel and methods of controlling and treating diseases caused by helminths and ectoparasites
Use of inhibitors of the KQT1 channel for preparing a medicament for treating diseases caused by helminths and ectoparasites Inhibitors of the KQT1 channel are a novel way of destroying helminths...
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6316495 |
Method for inhibition of retroviral replication
A method for inhibition of retroviral replication by manipulation of enzyme adenosine diphosphoribosyl transferase which endogenously inhibits retroviral reverse transcriptase. The method is useful...
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6291518 |
Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof
The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: ##STR1## wherein R 1 ...
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6291517 |
Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract
A method is disclosed for preventing and/or reducing stress-induced gastric injury by administering an amount of grape seed proanthocyanidin extract effective to inhibit injury is administered to...
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6287798 |
Esculetin derivatives
The invention concerns novel 6- or 7-substituted derivatives of esculetin (6,7-dihydroxy-2H-1-benzopyran-2-one), their synthesis, and their application as substrates for the detection of...
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6264969 |
Mole control system
A method is described for controlling or exterminating moles through the use of a bait composition in the form of a gel, paste, or grease. The composition includes an attractant and an active...
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6258840 |
Analogues or derivatives of quercetin (prodrugs)
Novel carbamate ester analogues or derivatives of Quercetin (prodrugs) are provided which have enhanced aqueous solubility and which are especially suitable for use as biodegradable prodrugs in...
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6251948 |
Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists
Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine...
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6251644 |
Method for inactivating non-enveloped viral contaminants with a photosensitizer by increasing viral permeability to the photosensitizer
A method is presented for inactivating non-enveloped viruses that may be contaminating a biological solution or suspension by mixing the solution or suspension with a photosensitizer to form a...
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6248778 |
Anticholestatic effect of luteolin
The invention relates to a drug for treating or preventing intrahepatic cholestasis, which is characterized by containing as active agent at least one compound with the general formula I, ##STR1##...
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6248730 |
Enhancing the toxicity of warfarin in rodents
The presence of a small amount of an antibiotic, such as tetracycline or a salt or derivative thereof, in warfarin-containing rodent baits enhances the toxicity of warfarin against rodents which...
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6207404 |
Coumarin-based CYP3A fluorescent assay reagents
Novel fluorescent substrates of human cytochrome P450 enzymes are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing cytochrome P450 enzyme...
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6194421 |
Inhibitors of metazoan parasite proteases
Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at...
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6187572 |
Method of inactivation of viral and bacterial blood contaminants
A method is provided for inactivating viral and/or bacterial contamination in blood cellular matter, such as erythrocytes and platelets, or protein fractions. The cells or protein fractions are...
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6184199 |
Active synergetic complex and cosmetic and/or pharmaceutical product containing this complex
The invention concerns a synergetic complex designed in particular for being incorporated in a cosmetic and/or pharmaceutical preparation for topical use on the skin and/or superficial body growth...
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6184246 |
Inhibition of cytokine production by polymethoxylated flavones
A method of inhibiting the production of cytokines, particularly inhibiting the production of tumor necrosis factorα, interleukin-10, and macrophage inflammatory protein-1α and the like, in a...
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6180662 |
Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides
The invention relates to the use of a) a compound or several compounds from the group consisting of flavonoids, or b) an active compound combination comprising a compound or several compounds...
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6180663 |
Therapeutic nasal inhalant
A therapeutic nasal inhalant for using bioflavanoids as a topical antioxidant. The therapeutic nasal inhalant includes a method for making a therapeutic nasal inhalant composition for treating...
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6180666 |
Use of gallic acid esters to increase bioavailability of orally administered pharmaceutical compounds
A method is disclosed for increasing bioavailability of an orally administered pharmaceutical compound comprising orally coadministering the pharmaceutical compound to a mammal in need of treatment...
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6177457 |
Process for the preparation of indacene compound
A process for preparing compounds of the formula: ##STR1## and intermediates for use in the process.
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6159505 |
Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine
Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other...
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