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7618998 |
Isoflavone derivatives and pharmaceutical compositions comprising the same
An isoflavone derivative is provided. The isoxazole derivative has following formula:
wherein R 1 and R 2 , independently, include C 1 -C 12 alkyl optionally substituted with oxirane,...
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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7612107 |
Treatment and inhibition of disease conditions using flexible heteroarotinoids
The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions...
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7601754 |
Flavonoid compounds as therapeutic antioxidants
Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a...
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7598291 |
Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7585892 |
Compound for promoting the growth of neural cells
Disclosed is a compound capable of promoting the growth and development of neurons, the proliferation of neural stem cells and inducing the neural stem cells to differentiate into neurons, which is...
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7585891 |
Pesticidal (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxole derivatives
Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where...
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7585890 |
Pharmaceutical compositions comprising flavonoids and menthol
The present invention relates to use of certain antiviral fragrances for reduction of viruses, in particular vira causing common cold. In one embodiment, the invention relates to pharmaceutical...
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7582675 |
Flavonoid compound and process for producing the same
A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial...
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7582674 |
Nutraceutical compositions and use thereof
Compositions including, as the active ingredients, resveratrol, a derivative, metabolite or analogue thereof, and at least one additional component selected from epigallocatechin gallate (EGCG),...
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7572824 |
Methods for minimizing thioamide impurities
Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are...
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7566737 |
Combinations of substituted 1,3-diphenylprop-2-en-1-one derivatives with other therapeutically active ingredients
The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives and combinations of said derivatives with other therapeutically active ingredients. The invention also concerns...
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7553869 |
Protein probe compounds, compositions, and methods
Coumarine/chinolone and Martina-type compounds, compositions, and method of using the compounds and compositions for protein detection, assay, quantitation, etc. are disclosed. The composition,...
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7553848 |
Vanilloid receptor ligands and their use in treatments
bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7550160 |
Composition for treating cancer cells and preparation method for the same
A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a...
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7544816 |
(−)-Epigallocatechin gallate derivatives for inhibiting proteasome
(−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides...
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7544717 |
2-amino- and 2-thio- substituted 1,3-diaminopropanes
Disclosed are compounds of the formula:
where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7544711 |
Use of nitroderivatives in urinary incontinence
The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other...
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7538137 |
1-O-β-D-glucopyranosylgeraniol-10,5-olide and use thereof
A novel natural compound having various therapeutically effects is provided. The compound is obtainable from Sibiraea leaves by aqueous extraction and is represented by a formula (1) as follows.
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7534812 |
Process for preparation of isochroman and derivatives thereof
The present invention relates to an improved process for preparing compounds of formula 1 on an industrial scale,
wherein R 1 , R 2 and R 3 are independently C 1-6 -alkyl, C 2-6 -alkenyl, C...
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7528250 |
Chroman derivatives and uses thereof
Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein m, p, q, Ar, R 1 , R 2 , R 3 and R 4 are as defined herein. Also provided are methods for preparing,...
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7524883 |
Eponemycin and epoxomicin analogs and uses thereof
The present invention provides compounds having formula (1): wherein R 1 -R 6 , A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
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7521475 |
Chondropsin-class antitumor V-ATPase inhibitor compounds, compositions and methods of use thereof
A composition comprising a substantially purified compound of the formula:
in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a...
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7514469 |
Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and...
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7514107 |
Treatment of diseases involving defective gap junctional communication
This invention relates to compositions containing polyphenols, for example, cocoa polyphenols such as flavanols and their related oligomers, and methods for treating abnormalities in gap junctional...
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7507762 |
Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
wherein A, B, X, Y, Z and R 5 are defined herein. The present invention...
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7507761 |
Benzopyran derivatives, method of production and use thereof
The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof.
wherein:
R 1 , R 2 , R 3 and R 4...
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7494674 |
Nutraceutical with tart cherries and method of treatment therewith
The present disclosure provides a nutraceutical for the use of a vacuolar flavonoid pigment from a natural source such as tart cherries as an additional compound as part of a mixture including at...
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7491413 |
Compositions and methods for treating and preventing virus infections
Provided are compositions comprising a vanilloid and tea catechins in amounts and proportions which combat virus infections in a human or animal. The vanilloid can be provided in the form of a...
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7488751 |
Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
Compounds of the Formula I:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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7488494 |
Compositions and therapeutic methods involving isoflavones and analogues thereof
Isoflavone compounds are described and recommended as therapeutic agents. Exemplified and preferred compounds are (a). Indications show compounds have good competitive binding to estrogen...
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7476673 |
Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
Compounds of the formula
where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases...
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7470722 |
Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
Disclosed herein are carbonyl compounds of Formula I as described herein.
Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune...
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7470721 |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
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7468445 |
Antigiardial agents and use thereof
The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic...
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7456214 |
Chromene-containing compounds with anti-tubulin and vascular targeting activity
Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are...
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7439265 |
Irciniastatins a and b
The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to <0.0001 μg/ml) murine and human cancer cell growth inhibitors, denominated herein as...
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7435722 |
Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous...
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7435705 |
Environmentally safe anti-fungal composition and methods of using same
Disclosed herein or novel, environmentally friendly compositions and methods for treating or preventing fungal growth, such as molds and mildew, on surfaces and in objects. Specifically exemplified...
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7432297 |
Reaction product of resorcin and methyl ethyl ketone
A compound of the following formula (I) or (II)
(in the formula (I), n represents an integer of 0 to 2)
(in the formula (II), m represents an integer of 0 to 2).
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7429576 |
Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded...
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7427686 |
(3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases
The present invention relates to compounds of the formula I in which substituents R 2 and R 3 are arranged in trans-configuration:
wherein:
R 1 is H or C1-C6 alkyl; C3-C7 cycloalkyl;...
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7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
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7417067 |
Composition and method for stabilizing the same
Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved...
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7405227 |
Treatment of cancer
Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed....
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7399784 |
Tocopherol and tocotrienol anti-obesity medicaments
Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form...
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7399783 |
Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids...
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7396855 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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7384976 |
Nebivolol and its metabolites in combination with nitric oxide donors, compositions and methods of use
The invention describes novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a...
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