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6218427 |
Chromene-3-carboxylate derivatives
The present invention provides a compound of the formula (I): ##STR1## wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally...
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6218369 |
Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative
The invention relates to methods for preventing, inhibiting, or suppressing tumors by administering to a person in need of such treatment a therapeutically effective amount of one or more...
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6214868 |
Method for preventing or treating coronary restenosis with catechin
A coronary restenosis in a mammal can be prevented or treated by administering an effective amount of a catechin thereto.
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6211211 |
Benzopyrans and their use as therapeutic agents
This invention relates to substituted benzopyran amides useful in treating certain medical conditions and to processes for preparing these compounds.
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6210679 |
Method for isolation of caffeine-free catechins from green tea
The process of the present invention relates to the isolation and purification of caffeine-free mixtures catechins from various different biomass sources, preferably from green tea leaves. More...
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6207702 |
Method for reducing postprandial oxidative stress using cocoa procyanidins
A method for reducing postprandial oxidative stress and associated pathologies by the dietary intake of cocoa procyanidins, such as epicatechin is disclosed.
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6201011 |
Therapeutic agent for allergic dermatitis
A therapeutic agent for allergic dermatitis caused by type IV allergic reaction, which contains diethyl L-lysylcromoglycate of the formula: ##STR1## or a nontoxic salt thereof as an active...
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6197808 |
Methods for treating hyperplasia
A method for a treatment of hyperplasia caused by papilloma virus, such as Condyloma acuminata, which comprises concomitantly topically and orally administering at least one tea catechin. Tea...
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6194450 |
Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'--...
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6191164 |
Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I ##STR1## and of the formula 1a...
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6187822 |
Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
The present invention pertains to a method for healing a wound in a mammal which comprises the steps of (A) providing a therapeutic wound healing composition comprising a therapeutically effective...
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6184219 |
Composition and methods employing it for the treatment of 5-HT-mediated disorders
The invention relates to a composition comprising a first component (a) which is (R)-5-carbamoyl-8-fluoro-3-N,N-dicyclobutylamino-3,4-dihydro
-2H-1-benzopyr an in the form of the free base, or a...
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6184246 |
Inhibition of cytokine production by polymethoxylated flavones
A method of inhibiting the production of cytokines, particularly inhibiting the production of tumor necrosis factorα, interleukin-10, and macrophage inflammatory protein-1α and the like, in a...
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6180662 |
Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides
The invention relates to the use of a) a compound or several compounds from the group consisting of flavonoids, or b) an active compound combination comprising a compound or several compounds...
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6180661 |
Bioflavonol-glycoside peresters and their incorporation into pharmacologically active concentrates and ultramicroemulsions
Spontaneously dispersible concentrates capable of forming ultramicroemulsions are described. The concentrates include esters of formula (I) and (II): ##STR1## wherein (a) R 1 , R 3 , R 4 , and R...
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6180663 |
Therapeutic nasal inhalant
A therapeutic nasal inhalant for using bioflavanoids as a topical antioxidant. The therapeutic nasal inhalant includes a method for making a therapeutic nasal inhalant composition for treating...
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6180666 |
Use of gallic acid esters to increase bioavailability of orally administered pharmaceutical compounds
A method is disclosed for increasing bioavailability of an orally administered pharmaceutical compound comprising orally coadministering the pharmaceutical compound to a mammal in need of treatment...
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6177458 |
Isochroman compounds and their production process
This invention relates to the isochroman compound of formula (I) ##STR1## and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating...
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6177457 |
Process for the preparation of indacene compound
A process for preparing compounds of the formula: ##STR1## and intermediates for use in the process.
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6177449 |
Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them
Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for...
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6174710 |
Spirolaxine derivatives for treating gastrobuodenal diseases
Spirolaxine, the compound of formula (I) ##STR1## wherein R is H, and the novel compounds of formula (I) wherein R is (C 1 -C 6 )alkyl or CH 3 (CH 2 ) n CO and n is 1, 2, 3 or 4 are useful in...
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6165984 |
Naringin and naringenin as inhibitors of acyl CoA-cholesterol-o-acyltransferase
Methods for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating...
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6166068 |
Immunomodulator, cell adhesion inhibitor, and agent for treating, and preventing autoimmune diseases
Autoimmune diseases, cell adhesion inhibition and immunomodulation are treated or effected by a method, comprising, treating a patient with a therapeutically effective amount of a...
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6162826 |
Genipin derivative having anti hepatitis B virus activity
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6159972 |
Combination of a selective 5-HT.sub.1A antagonist and a selective ub . h5-HT.s1B antagonist or partial agonist
The invention relates to a combination of a first component (a) which is a selective 5-HT 1A receptor antagonist having the formula I wherein R 1 is n-propyl or cyclobutyl, R 2 is isopropyl,...
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6159505 |
Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine
Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other...
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6156791 |
Methods for treatment using procyanidin topoisomerase inhibitors
Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants....
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6156723 |
Compositions comprising inhibitors of estrogen response
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
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6149923 |
Antirheumatic agent
An antirheumatic agent comprising diethyl L-lysylcromoglycate of the following formula ##STR1## or a nontoxic salt thereof as an active ingredient. This compound has an anti-inflammatory action and...
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6150400 |
Method for treating vulvar vestibulitis
The present invention provides an improved method for treating vulvar vestibulitis in a patient, comprising applying to the vestibule or the vestibule and the vagina of a patient an effective...
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6143788 |
Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to...
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6136848 |
Flavone derivative and medicine comprising the same
This invention relates to a flavone derivative represented by the formula (1) or a salt thereof, and also to a medicine containing the same. ##STR1## wherein A represents H, halogen, phenyl,...
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6136832 |
5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones and methods of use therefor
The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones;...
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6136849 |
Antibacterial and antifungal flavanones from Eysenhardtia texana
An activity-guided fractionation of a methanol-dichloromethane extract obtained from the aerial parts of Eysenhardtia texana Kunth. (Fabaceae) led to the isolation of two new antibacterial and...
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6133241 |
Bioflavonoids as plasma high density lipoprotein level increasing agent
A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R...
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6130254 |
Methods for inhibiting photoaging of skin
Methods are provided for ameliorating various effects of UVA and UVB radiation from the sun, comprising administering compositions including an ingredient that prevents photoaging from MED and...
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6130251 |
Alkoximinoacetic acid amides
The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests.
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6126940 |
Hair-growing agent comprised of proanthocyanidins
A hair-growing agent comprising proanthocyanidin as the active ingredient. The present invention provides a hair-growing agent having strong pharmaceutical effects.
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6124346 |
Estrogen agonist/antagonists treatment of atherosclerosis
A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque....
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6123944 |
Icariin preparations
Icariin-containing preparations obtained from the aerial parts of a plant of the genus Epimedium, comprising about 15% to about 95% icariin by weight and about 5% to about 80% non-icariin flavones...
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6124347 |
Chromene derivatives and salts thereof, and pharmaceuticals containing the same
Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R 1 s represent alkyl, alkoxy or like groups, R 2 represents a hydrogen atom or an alkyl group, R 3 ...
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6124284 |
Bicyclic amide derivatives and their use as muscle relaxants
Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.
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6121010 |
Methods and assays useful in the treatment of alcohol dependence or alcohol abuse
A method for the treatment of alcohol abuse using daidzin and compounds analogous to daidzin is disclosed. Also disclosed is a method for screening compounds having antidipsotropic activity.
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6121274 |
Dihydrobenzofurane
The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors.
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6110960 |
Dihydrobenzopyran and related compounds useful as anti-inflammatory agents
A compound having structure (1) wherein (a) X is selected from the group consisting of O, S, SO, or SO 2 ; (b) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from...
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6110963 |
Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure ##STR1## wherein A is C or N; B is O, S, N, or CHCH; E is ##STR2## or --X--D; D is ##STR3## or alkyl of 1-12 carbon...
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6110964 |
Bicyclic hydroxamic acid derivatives
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6103771 |
Method of treating neuroma pain
Methods of treating a host suffering from neuroma pain are provided. In the subject methods, a topical local anesthetic composition is applied to a keratinized skin site of the host proximal to the...
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6096316 |
Composition for limiting and attenuating the visible symptoms of natural or accidental ageing of the skin
The composition is characterized in that it contains an extract of Chrysanthellum indicum with low concentration comprising 0.0001% to 0.05% of equivalent dry extract of Chrysanthellum indicum. It...
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6093408 |
Skin care compositions
The present invention provides compositions and methods for treatment of human skin. Such methods include those for regulating sebum on facial skin of a human subject, comprising applying to said...
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