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6528489 |
Mycotoxin derivatives as antimitotic agents
The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic...
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6528042 |
Compositions of flavonoids for use as cytoprotectants and methods of making and using them
Non-naturally-occurring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. These compositions comprise a flavonoid or derivative thereof and...
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6524832 |
DNA damaging agents in combination with tyrosine kinase inhibitors
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
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6524566 |
Synthetic soil-extract materials and medicaments for herpes viruses based thereon
Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an...
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6524630 |
Use of cocoa procyanidins combined with acelylsalicyclic acid as an anti-platelet therapy
The invention relates to the use of cocoa procyanidins in combination with an aspirin as an anti-platelet therapy and compositions comprising cocoa procyanidins and aspirin (acetylsalicyclic acid).
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6525088 |
Agent for measurement of singlet oxygen
Compounds represented by the following general formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, or a C...
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6521641 |
Male anti-fertility agents
Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.
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6509353 |
Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
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6506792 |
Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
The instant invention relates to sulphamate compounds of formula I, wherein A represents a ring structure, B represents a ring structure, D a ring structure, C is a bond, E is a link joining ring...
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6495524 |
Benzo&lsqb b&rsqb pyran derivatives useful as external agents for the skin
To provide an external agent for thee skin that not only exhibits excellent effects of prevention and amelioration of skin pigmentation but also has no fear of giving adverse influences to the skin...
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6495593 |
Compositions for preventing or treating adverse physiological effects associated with cardiac disease
A method is disclosed for preventing or treating the adverse physiological effects associated with cardiac disease by administering a purified proanthocyanidin composition to the person in an...
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6492415 |
Use of benzopyranols to treat neurological disorders
Benzopyran derivatives and analogs are disclosed as useful for the treatment and/or prophylaxis of neuralgia, trigeminal neuralgia, neuropathic pain, dental pain and cancer pain.
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6492390 |
Substituted benzopyran analogs for the treatment of inflammation
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular...
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6492389 |
Small molecule inhibitors of BCL-2 proteins
Small molecule inhibitors of Bcl-2 function are used to induce apoptosis of cells which are subject to Bcl-2, which cells are otherwise subject to Bcl-2 mediated blockage of apoptosis. The...
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6492414 |
Methods and compositions for the treatment and prevention of lung disease
Methods and compositions for the treatment of lung disease such as emphysema and/or bronchopulmonary dysplasia in a mammal. Also disclosed are methods and compositions promoting the formation of...
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6486197 |
Substance ft-0554 and process for producing the same
The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to...
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6486198 |
Compounds and methods for the treatment of post traumatic stress disorder
The application relates to the use of topiramate and related sulfamates for the treatment and/or prophylaxis of post traumatic stress disorder (PTSD).
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6479539 |
Procyanidin compositions and methods for making the same
Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants....
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6479054 |
Process for obtaining genistin-rich isoflavone composition
A process for simply and efficiently obtaining an isoflavone composition having a high ratio of genistin, which useful as a food material and the like, wherein in the process for obtaining genistin...
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6472423 |
Pharmaceutical composition
The invention relates to a composition comprising of a first component (a) which is (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzop
yran-5-carboxamide in the form of the free base,...
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6472436 |
Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing...
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6471973 |
Flavonoide esters and their use notably in cosmetics
The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in...
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6469053 |
Use of procyanidins in the maintenance of vascular health and modulation of the inflammatory response
Cocoa extracts which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an...
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6465436 |
Method for treating alcohol intoxication and alcohol abuse
Treatment for alcohol dependence or intoxication that involves administering a pharmaceutical composition containing an extract of the kudzu plant, Pueraria lobata.
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6455578 |
Aromatic derivatives and iron complexes thereof for the use as normalizing agents of the iron level
The present invention is directed to aromatic derivatives of formula (I), wherein: R 1 is (a), wherein R 3 and R 4 are selected from between H and OH, provided that R 3 and R 4 are not...
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6455577 |
Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same
A compound of formula (I) treating or preventing an elevated blood lipid level-related disease and inhibiting the activities of acyl-CoA:cholesterol-O-acyltransferase(ACAT) and...
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6455032 |
Composition and method for protecting skin from UV induced immunosuppression and skin damage
Compositions and a method of protecting skin from either UV-induced immunosuppression or from UV-induced skin damage using a composition containing an extract of soy or clover, and/or the...
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6451846 |
Isocoumarin derivatives inhibiting angiogenesis
The present invention relates to novel isocoumarin derivatves inhibiting angiogenesis, a method for preparation thereof and pharmaceutical compositions comprising the said derivatives as...
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6447809 |
Composition for promoting healthy bone structure
A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline...
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6448238 |
Inhibitors of β-lactamases and uses therefor
The invention provides novel non-β-lactam inhibitors of β-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the...
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6444709 |
Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same
The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or...
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6441029 |
Method of suppressing tumor growth with combinations of isoprenoids and statins
A method of inhibiting the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of exposing tumor cells to an effective amount of a composition comprising at least...
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6436914 |
2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists
Compounds are provided having the formula including pharmaceutically acceptable salts thereof, wherein R 1 is lower alkyl, aryl or arylalkyl; A is hydrogen or B is hydrogen, alkyl, alkenyl, or...
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6432996 |
Pharmaceutical composition
To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of...
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6428973 |
Compositions and methods for evaluating bone resorption
Compositions and methods for the evaluation of bone resorption and bone resorption-related diseases are disclosed. The compositions include a human osteoclast-like cell line capable of resorbing...
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6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more...
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6426362 |
Formulations of tocopherols and methods of making and using them
Non-naturally-occuring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. The compositions comprise a tocopherol and/or a derivative thereof,...
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6423744 |
Method of diminishing the adverse effects of interleukin-2
A method and composition for preserving or enhancing the beneficial effects of interleukin-2 (IL-2) while simultaneously mitigating the adverse effects of IL-2 on a subject is disclosed. The method...
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6423743 |
Cocoa extract compounds and methods for making and using the same
Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds...
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6423747 |
Cosmetic and dermatological preparations with flavonoids
The invention relates to cosmetic and dermatological formulations having a) a content of a compound or several compounds from the group consisting of flavonoids, or having b) a content of an...
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6420369 |
Anticonvulsant derivatives useful in treating dementia
Anticonvulsant derivatives useful in treating dementia and/or behavioral and psychotic disturbances in dementia are disclosed.
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6420401 |
1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
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6417224 |
Prophylactic, therapeutic agent for osteoporosis
The prophylactic, therapeutic agent for osteoporosis of the invention is a combination of an indigestible oligosaccharide with phytoestrogen which inhibits bone loss. The action of inhibiting the...
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6413998 |
Compositions and methods for treating bone deficit conditions
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic...
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6409996 |
Composition comprising one or more flavonoids, method of obtaining such composition and use thereof as UV-absorbing agent
A flavonoid-containing sunscreen composition having UV absorbency at 282 nm in water contains at least one flavanone and at least one flavone, the flavanone providing 75 to 98% of the UV absorbency...
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6410052 |
Tea catechins in sustained release formulations as cancer specific proliferation inhibitors
The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of...
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6410588 |
Use of cannabinoids as anti-inflammatory agents
The application relates to the identification that cannabinoids, such as cannabidiol can be used to treat inflammatory diseases. Cannabinoids for use in treating inflammatory diseases, methods of...
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6410586 |
Modulators of protein tyrosine phosphatases (PTPases)
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
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6410567 |
Pesticide containing a photosensitizer and an attractant
The present invention relates to a new pesticide which is based on a photosensitizer or combination of photosensitizers of the tetrapyrrole and/or tetraazapyrrole series which may comprise a...
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6410061 |
Tea catechins as cancer specific proliferation inhibitors
The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of...
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