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7427686 |
(3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases
The present invention relates to compounds of the formula I in which substituents R 2 and R 3 are arranged in trans-configuration:
wherein:
R 1 is H or C1-C6 alkyl; C3-C7 cycloalkyl;...
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7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
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7417067 |
Composition and method for stabilizing the same
Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved...
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7405227 |
Treatment of cancer
Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed....
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7399784 |
Tocopherol and tocotrienol anti-obesity medicaments
Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form...
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7399783 |
Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids...
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7396855 |
Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition...
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7384919 |
Increased solubility flavanolignan preparations
The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on...
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7384976 |
Nebivolol and its metabolites in combination with nitric oxide donors, compositions and methods of use
The invention describes novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a...
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7381743 |
Macrocycles for the treatment of cancer
The present invention relates to new macrocycles of the general formula (I) as well as their use for the treatment of cancer diseases
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7375132 |
Compounds and methods for inhibiting cellular responses to hypoxia
Compounds and compositions of the following formula:
and analogs and stereoisomers thereof (and pharmaceutically acceptable carriers). Additionally disclosed is a method of inhibiting...
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7371775 |
7-carboxymethyloxy-3′,4′,5-trimethoxy flavone monohydrate, the preparation method and uses thereof
The present invention relates to 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate which is a non hygroscopic product suitable for the preparation of metered dose of...
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7368434 |
Compounds useful for the inhibition of ALDH
The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol...
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7365095 |
Chromane and chromene derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 2 , R 3 , R 4 , y, m, n, and Ar are as defined, and described in classes and subclasses...
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7358245 |
Treatment of gastroesophageal reflux disease
The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed.
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7351737 |
4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity
Compounds of the formula
where the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with...
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7351738 |
Substituted ureas and carbamates
The invention provides compounds of formula I:
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful...
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7345089 |
Microbial method of making equol-containing composition and product made
This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition...
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7345090 |
Galenical formulation
The invention relates to compounds of the formula I
where R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in claim 1. The compound is suitable in particular for use in skin care...
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7338941 |
Pharmaceutical compositions for lowering blood glucose and blood cholesterol levels
Methods of treating a mammal with high blood-glucose, or high blood-cholesterol, levels with isovitexin, and pharmaceutical compositions comprising the same are disclosed.
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7335683 |
Compositions and methods for cystic fibrosis therapy
Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating...
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7329687 |
Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents
Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7314634 |
Use of polyphenols to treat skin conditions
A composition is provided to treat and/or prevent for treating skin conditions including fine lines and wrinkles, acne rosacea, surface irregularities of the skin and hyper-pigmentation melasma of...
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7314642 |
Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's...
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7312243 |
Materials and methods for treatment of gastrointestinal disorders
The subject invention pertains to materials and methods for the prevention and treatment of gastrointestinal diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative...
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7312242 |
Use of parthenolide derivatives as antileukemic and cytotoxic agents
Compounds of the formula having anti-tumor activity, wherein R 1 and R 2 are as described herein
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7306789 |
Method of stimulating hair growth using benzopyrans
The present invention is directed to methods of stimulating hair growth by administering particular benzopyran compounds.
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7307088 |
Substituted anthranilic amide derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7307100 |
2-Benzoylchromone derivatives
Novel compounds of the formula I
in which
R, X, n and m are as defined herein are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for...
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7297715 |
PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
A class of chromane and chromene compounds having the structure shown below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment and...
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7271193 |
Inhibitors of cyclin-dependent kinases and their use
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia),
wherein R 1 , R 2 , R 3 , R 4...
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7265130 |
NPY Y5 antagonist
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I):
wherein R 1 is lower alkyl, cycloalkyl or the...
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7256214 |
Flavanone compound and uses thereof
Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone...
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7252845 |
Synergistic compositions containing aromatic compounds and terpenoids present in Alpinia galanga
Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alpinia galanga (Zingiberaceae) show synergistic...
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7244725 |
Acetyl 2-hydroxy-1, 3-diaminoalkanes
Disclosed are compounds of the formula:
where variables Z, X, R 15 , R 2 , R 3 , and R C are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7244763 |
Compounds that modulate PPAR activity and methods of preparation
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
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7238376 |
Black tea extract for prevention of disease
Compositions and methods for preventing and treating disease are provided. The compositions are extracts of black tea that include a mixture of theaflavin-3-gallate and theaflavin-3′-gallate.
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7232844 |
Insect repellent compounds
Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis...
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7226945 |
Estrogen receptor-β ligands
A method for treating a disease associated with the estrogen receptor-β, comprising the step of administiering a therapeutically-effective amount of a compound that satifies the equation: K iαA...
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7217735 |
Methods and compositions for enhancing delivery of therapeutic agents to tissues
The invention, at least in part, is directed to methods for enhancing delivery of therapeutic agents, such as macromolecules and drugs, into the interior of tissues, such as solid tissues or...
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RE39593 |
1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects
1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I
a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical...
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7202222 |
Methods for treatment of obesity and effective fat loss promotion
Methods for treating obesity, reducing total weight and reducing body fat mass by administering a composition comprising dihydroquercetins and root-derived aralosides A, B, C and D is disclosed.
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7199152 |
TNF-α production inhibitor comprising kavalactone as an active ingredient
The present invention provides a TNF-α production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-α...
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7196081 |
Compounds with hydroxycarbonyl-halogenoalkyl side chains
The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral...
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7192982 |
Modulators of peroxisome proliferator activated receptors
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or...
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7192612 |
Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins,...
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7183314 |
Compound for treatment of anxiety and methods of preparation and use thereof
A method for preventing or for treating anxiety in a patient in need thereof comprising administering wogonin to the patient in an effective dose that does not cause sedative or myorelaxant side...
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7179476 |
Medical composition for external use for dermatosis
The object of the present invention is to provide a dermal composition for external use which keeps skin healthy and demonstrates a sufficient effect in treating skin diseases. The present...
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