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5480645 |
Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular,...
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5480905 |
Benzodioxane derivatives
Compounds represented by the general formula (I): ##STR1## (where R 1 is an admantyl group; R 2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or an aralkyl group; R 3 is a...
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5480912 |
Method of treating HIV-1 with α-substituted benzenemethanamine derivatives
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
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5480903 |
3,4-diarylchromans for inhibiting calmodulin activity
A method for inhibiting is disclosed comprising administering, 3,4-diarylchromans and their pharmaceutically acceptable salts.
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5478857 |
Use of PLA.sub.2 inhibitors as treatment for alzheimer's disease
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of...
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5475023 |
Aqueous pharmaceutical formulations of sodium cromoglycate
A pharmaceutical formulation comprising a substantially clear aqueous solution having a viscosity of less than 10 mPa.s containing 3.5 to 5% w/v of 1,3-bis(2-carboxychromon-5-yloxy)-propan-2-ol, or...
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5472977 |
Method for the treatment of uterine fibroid desease
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid...
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5472979 |
1,2,3,4-tetrahydronaphthalene compounds
its enantiomers and its addition salts with a pharmaceutically acceptable base, and medicinal products containing the same are useful as anti-thrombotic.
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5470872 |
Benzopyranols
Novel Compounds A compound of formula (I): ##STR1## where the substituents are defined later in the specification. The compounds are useful as muscle relaxants and as such have a number of...
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5464862 |
Method for inhibiting bone loss using centchroman derivatives
Methods and pharmaceutical compositions for reducing bone loss are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment of...
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5462965 |
Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases
A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with...
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5457114 |
Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
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5457108 |
5-oxo-dibenzo[a,d]cyclohepta-1,4-dienes
The invention relates to substituted 5-oxo-di-benzo[a,d]cyclohepta-1,4-dienes of the formula (I) ##STR1## processes for their preparation and their use as retroviral agents.
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5457103 |
3',5'-di-tert.-butyl-4'-hydroxy flavones
Compounds of the general formula (I): ##STR1## in which R represents: a hydrogen atom, or a radical --OR' in which R' is as defined in the description.
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5457124 |
Carboxylic acid Leukotriene B4 antagonists
The invention relates to compounds selected from the group consisting of the formulas: ##STR1## wherein R 2 and Ph are as described herein. These compounds are potent leukotriene B 4 antagonists...
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5453421 |
Aryl and heterocyclic substituted propenamide derivatives
Novel compounds useful, for example, for the treatment of ischemic conditions and arrhythmia are disclosed. The compounds have the formula ##STR1## wherein X is oxygen or sulfur and the R groups...
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5451603 |
3,4-diarylchromans for treatment of dermatitis
Methods for the treatment of dermatitis are disclosed wherein 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments, including oral and topical medicaments,...
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5449794 |
Benzopyran phenol derivatives for use as antibacterial agents
A method of inhibiting microorganisms, including bacteria, using benzopyran phenol derivates from propolis. Propolis is extracted with an alcohol, and the resulting compounds are effective as...
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5447719 |
β-glucuronidase inhibitor
A β-glucuronidase inhibitor comprising at least one compound selected from the group consisting of baicalin, oroxylin A-7-O-glucuronide and luteolin-3'-glucuronide; an extract of scutellaria root...
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5441974 |
Phenyl amidines lactones useful as platelet aggregation inhibitors
This invention relates to compounds having the following formula ##STR1## wherein Z is a lactone or a lactone which is fused to a benzene ring which are useful in the inhibition of platelet...
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5438074 |
3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.
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5430060 |
Acetamide derivatives
The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of...
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5428027 |
Substituted semicarbazone arthropodicieds
Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.
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5424331 |
Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis
A composition for the treatment or prevention of osteoporosis, is disclosed, which comprises: (a) 75 to 200 parts of one or more phytoestrogen compounds; (b) 0 to 100 parts of dried licorice...
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5416118 |
Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
Novel bicyclic amides of the formula ##STR1## wherein Ar 1 and Ar 2 are phenyl, R 2 -substituted phenyl, heteroaryl or R 2 -substituted heteroaryl, wherein R 2 is 1 to 3 substituents...
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5414015 |
Anti-skin tumor promoting composition
An anti-skin tumor promotor comprising a compound of the general formula ##STR1## wherein R means a hydrogen atom or a hydroxyl group. The promotor may be an extract of the crude drug Scutellaria...
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5413997 |
Triphenylmethane derivatives
A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
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5407961 |
α-substituted benzenemethanamine derivatives and pharmaceutical use
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
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5403846 |
Spirocycles
Compounds of the general formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form enantiomer, diastereomer or mixtures thereof are Class III antiarrhythmic agents.
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H001427 |
Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
The use of substituted flavonoid compounds which have the immunomodulatory activity of (1) boosting natural killer activity in vivo and (2) inducing interferon, and (3) belong to the family of...
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5399584 |
Use of flavone derivatives for gastroprotection
The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective...
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5399561 |
Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity
Compounds of the formula ##STR1## where R 1 and R 2 are hydrogen, lower alkyl of 1-6 carbons, or halogen; R 3 is hydrogen, lower alkyl of 1-6 carbons, halogen, OR 11 , SR 11 , OCOR 11 , SCOR 11...
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5395842 |
Anti-estrogenic compounds and compositions
Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress...
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5393729 |
3-aryl-pyrone derivatives
The invention relates to 3-aryl-pyrone derivatives of the general formula (I) ##STR1## in which the substituents are as defined in the specification. The compounds are useful as pesticides,...
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5391568 |
Inhibition of lung tumorigenesis by administration of a polyphenol
A method is provided for reducing the incidence of lung cancer in a mammal by administering thereto a pharmacologically effective amount of epigallocatechin gallate (EGCG). The EGCG may be...
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5391569 |
New chromene compounds having a triene side chain
A compound selected from those of formula (I): ##STR1## in which the groups R 1 to R 8 are as defined the description. Medicaments.
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5389646 |
Methods for treatment and prevention of bone loss using 2,3-benzopyrans
Methods and pharmaceutical compositions for reducing bone loss are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment...
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5387604 |
1,4 benzodioxin derivatives and their use as serotonin 5HT.sub.1A agonists
The present invention is directed to a new class of serotonin 5HT 1A agonists.
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5385931 |
Sulfonamides derived from benzocyclic or benzoheterocyclic acids, their preparation and application in therapeutics
The invention relates to new sulphonamide derivatives of benzo-cyclic or benzo-heterocyclic acids and their derivatives of general formula I ##STR1## in which: R represents a straight-chain or...
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5384327 |
Anticonvulsant sorbopyranose sulfamates
Sulfamate derivatives having the following formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as herein defined, have been found to exhibit anticonvulsant activity and are...
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5382572 |
Alkyl and acyl substituted quinolines
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically...
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5380748 |
Trialkylamine derivative and ameliorant for digestive tract movement containing the same
A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R 1 and R 2 may be the same or different from each other and each...
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5378694 |
Acyl and alkoxy substituted quinolines
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1.0: ##STR1## and their...
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5376679 |
Bicyclic or tricyclic biocidal compounds
Compounds of the general formula ##STR1## where R 2 and R 3 together, or R 3 and R 4 together, represent an optionally substituted hydrocarbyloxy chain; the ring is optionally substituted at...
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5374643 |
Aryl urea (thiourea) and cyanoguanidine derivatives
Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.
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5373023 |
Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them
The invention provides compounds which are tetrahydronaphthalene derivatives of the formula (I) ##STR1## wherein R 1 represents a halogen atom, a cyano group, a nitro group, an unbranched (C 1 -C...
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5348973 |
Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog,...
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5348974 |
Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. The isolation of...
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5348975 |
7-chromanyl esters of phenols and benzoic acids having retinoid-like activity
Retinoid like activity is exhibited by compounds of the formula ##STR1## wherein the R 1 -R 6 groups are independently H or straight chain or branched chain lower alkyl or cycloalkyl of 1 to 6...
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5348976 |
Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same
The present invention provides a condensed heterocyclic derivative represented by a formula: ##STR1## wherein R 1 represents a lower alkyl group, an alkenyl group, or the like, R 2 , R 3 , R 4 , R...
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