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5612054 |
Pharmaceutical compositions for treating gastrointestinal distress
This invention relates to a pharmaceutical composition for treating gastrointestinal distress comprising an effective amount of an antidiarrheal composition, e.g. loperamide, and an antiflatulent...
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5607965 |
Lipoprotein (a) lowering agent, cholesterol lowering agent and medicaments comprising these agents respectively
Described are a lipoprotein (a) lowering agent and a cholesterol lowering agent each comprising as an effective ingredient a proanthocyanidin contained in a grape extract or the like; and...
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5605929 |
Methods and compositions for inhibiting 5α-reductase activity
Disclosed are a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, their method of synthesis, and...
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5605896 |
Bicyclic heterocyclic derivatives having α.sub.1 adrenergic and 5HT.sub.1A activities
This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and...
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5603936 |
Process for removing light absorbing compounds from epidermal plant cells
A process is provided for harvesting light absorbing compounds from the epidermal cells of a plant. The plant is subjected to artificial light having wavelengths in the range of 260 to 400 nm. The...
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5602130 |
Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl,...
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5594028 |
Anti-tumor method and compounds
This invention provides certain sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.
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5591771 |
Use of propolis components as an adjuvant
A method of providing adjuvant activity utilizing one or more of the components of propolis, such as the benzopyran phenol derivates, pinocembrin, pinobanksin-3-acetate and naringenin, and...
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5589515 |
Cosmetic composition and an emulsion composition
A cosmetic composition and an emulsion composition respectively comprising 0.1 to 99 weight % of an oily component and 99.9 to 1 weight % of a watery component are provided and the oily component...
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5589504 |
Treatment of newborn jaundice
Based on the discovery that the human bilirubin/phenol UDP-glucuronosyltransferase ugt1 gene complex contains an electrophile responsive element and the knowledge that the rat NADP(H):quinone...
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5587176 |
Methods of using hesperetin for sebum control and treatment of acne
The subject invention relates to methods for sebum control and treatment of acne in mammalian skin and scalp comprising administration of hesperetin, having the structure: ##STR1## or a...
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5583155 |
6-amino-1,2-benzopyrones useful for treatment of viral diseases
Unsubstituted or substituted 6-amino-1,2-benzopyrones are potent, selective and non-toxic inhibitors and suppressants of viral infections in a mammalian host. The compounds are particularly useful...
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5578590 |
Pharmaceutical composition preparation for use in inhibiting protein kinase C
The present invention provides a method of inhibiting protein kinase C in a mammal having a tumor system which contains protein kinase C, which mammal is undergoing cytostatic therapy. The method...
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5576346 |
Process for treating uremic pruritus
A process and pharmaceutical composition for treatment of uremic pruritus in humans is disclosed. The pharmaceutical composition comprises of a chromone compound of the following formula, or a...
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5574061 |
Benzopyran derivative, process for producing the same and pharmaceutical composition containing the same
A benzopyran derivative represented by the formula (I) or its pharmaceutically acceptable salt: ##STR1## wherein either one of X and Y stands for the following formula ##STR2## and the other one of...
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5571844 |
Amidinophenylalanine derivatives, a process for their preparation, their use and compositions containing these as anticoagulants
The invention relates to amidinophenylalanine derivatives, to the synthesis of these compounds, to their use and to pharmaceutical compositions which contain these compounds which act as thrombin...
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5569669 |
Alkylaminoindane compounds
The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 2 ', R 2 ", R 2 '", R 3 and n are as defined in the description, an optical isomer, and an...
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5569459 |
Pharmaceutical compositions for the management of premenstrual syndrome and alleviation of menopausal disorders
A composition is disclosed for controlling the stimulation of estrogen production, which comprises: (a) 15 to 120 parts by weight of one or more phytoestrogen compounds calculated as a free...
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5563164 |
Phospholipase A.sub.2 inhibitors
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of...
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5563167 |
Abruquinone derivatives and their uses
Disclosed are methods of isolation and purification of active constituents from Hsian-ssu-tsu (Abrus precatorius L.), and the therapeutical applications of the purified compounds. From the...
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5563170 |
Substituted cyanoimino benzopyranes
Novel compounds are disclosed having the formula ##STR1## and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. These compounds are useful, for example, as cardiovascular agents...
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5554600 |
Methods for inhibiting endometriosis
The present invention provides a method for inhibiting endometriosis comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is...
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5554633 |
Substituted amines as tachykinin receptor antagonists
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR 9 , where R 9 is...
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5552435 |
Benzopyran and related LTB antagonists
Benzopyran and other benzo-fused leukotriene B 4 antagonists have the formula ##STR1## wherein R 1 is a phenyl or substituted phenyl group, and A, n, R 2 and R 3 are as defined herein.
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5552436 |
Process for treating hemangioma
A process and pharmaceutical composition for treatment of hemangioma in humans is disclosed. The pharmaceutical composition comprises a chromone compound of the following formula, or a...
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5552444 |
Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones,...
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5545661 |
Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds
The present invention provides a method for inhibiting bone loss comprising administering to a human in need of treatment an effective amount of a compound of formula I ##STR1## wherein each R is...
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5545398 |
Method and compositions for topical application to the skin of tocotrienol for prevention and/or treatment of skin damage
A method for the prevention and/or treatment of skin or hair damage, particularly inflammation and aging of skin and hair damage from sunlight and chemicals, in which a tocotrienol, a derivative...
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5543428 |
Method for treating resistant tumors
This invention provides a method of reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of a series of phenoxy...
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5541199 |
Chroman-2-ylmethylamino derivatives
Compounds of the formula: ##STR1## in which n is one of the integers 1, 2, 3,or 4; m is one of the integers 0 or 1; R is ##STR2## or a pharmaceutically acceptable salt thereof, are inhibitors of...
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RE35279 |
Hydantoin derivatives
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives...
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5525625 |
2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran inhibits MEK and, as such, is effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
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5523087 |
Pharmaceutical compositions for the treatment of diabetic male sexual dysfunction
A pharmaceutical composition is disclosed for the treatment of diabetic male sexual dysfunction, which comprises: (a) 45 to 60 parts by weight of one or more phytoestrogen compounds calculated...
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5523319 |
Compounds of the benzo-heterocycle family
The present application relates to novel compounds of the benzo-heterocycle family as well as to processes for their preparation and to the intermediate compounds obtained.
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5516528 |
Dietary phytoestrogen in estrogen replacement therapy
Disclosed is a pharmaceutical composition for oral delivery. The composition includes about 1-2 mg mammalian estrogen and about 25-100 mg phytoestrogen. Compositions of the type described above are...
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5514382 |
Daily vitamin and mineral supplement for women
A daily vitamin and mineral supplement for women comprising vitamin A, beta-carotene, niacin, riboflavin, pantothenic acid, pyridoxine, cyanocobalamin, biotin, para-aminobenzoic acid, inositol,...
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5510373 |
Cardioprotective agents
This invention relates to certain hydroxy derivatives of 3,4-dihydro-2,5,7,8-tetraalkyl-2H-1-benzopyran-2-carboxylic acids and the lactones thereof, to the processes and intermediates useful for...
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5510374 |
3-aminochroman compounds
The invention relates to compounds of the formula (I): ##STR1## in which: Z represents oxygen, R 1 represents alkyl, R 2 represents hydrogen or alkyl, n represents 1 through 6, R 3 ...
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5508275 |
Lipid-selective antioxidants and their preparation and use
Lipid-selective antioxidants of the formula I (A) a (L)(X) a , (I), in which A=an antioxidative component, L=a bridging member, X=a lipophilic...
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5506211 |
Genistein for use in inhibiting osteroclasts
Disclosed are methods and compositions for use in inhibiting osteoclast activity and, particularly, the osteoclast acid secretion that leads to bone-degradation. It is shown that the isoflavone...
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5506243 |
Sulfonamide derivatives
Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as...
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5504105 |
Pharmaceutical compositions containing ipriflavone, process for the preparation thereof and relative therapeutic use
Oral pharmaceutical compositions containing Ipriflavone comprising oily vehicles that promote absorption of the drug enabling the dosage to be simplified.
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5500425 |
Chroman derivatives and a method of treating 5-HT mediated disorders
Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.
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5500444 |
Cardioprotective tocopherol analogs
This invention relates to quaternary ammonium salts of certain 2H-1-benzopyran derivatives, to the intermediates and processes useful for their preparation, to their free-radical scavenger and...
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5498631 |
Method for treatment of menopausal and premenstrual symptoms
A method is provided for preventing or treating symptoms of menopause, premenstrual syndrome, or a condition resulting from reduced levels of endogenous estrogen, by administering to the woman an...
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5491152 |
Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT),...
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5484810 |
Tissue protective tocopherol analogs
This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and...
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5482958 |
Method for treating endometriosis
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid...
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5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
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5482966 |
Oxime derivatives
The invention concerns oxime derivatives of the formula I ##STR1## wherein R 4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and...
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