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5747528 |
Chroman derivatives as anti-oxidants
Chroman derivatives of Formula I or a pharmaceutically acceptable salt thereof are inhibitors of VCAM-1 and ICAM-1 and are thus useful in the treatment of inflammation, atherosclerosis, restenosis,...
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5733920 |
Inhibitors of cyclin dependent kinases
The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These...
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5733926 |
Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions
A method of treating or preventing, in a human patient, dementia of Alzheimer type, or age-related loss of cognitive function, said method comprising administering to said patient an isolated...
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5726034 |
Aglucone isoflavone enriched vegetable protein extract and protein material, and high genistein and daidzein content materials and process for producing the same
An aglucone is isoflavone enriched vegetable protein extract and protein material are provided, as well as a high genistein content material and a high daidzein content material. Isoflavone...
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5726202 |
Benign prostatic hypertrophy
The present invention provides novel uses of compounds of general formula I ##STR1## wherein R 1 , R 4 and R 5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower...
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5720956 |
Method of controlling the reactivity of human blood platelets by oral administration of the extract of the maritime pine (pycnogenol)
A method of inhibiting platelet aggregation with an agent which is able to normalize and enhance platelet reactivity without adversely affecting the bleeding time. The method additionally prevents...
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5719178 |
Methods and compositions for treating attention-deficit/hyperactivity disorder
A regimen and composition for treating Attention Deficit/Hperactivity Disorder (ADHD) by the use of proanthocyanidin both with and without a heterocyclic anti-depresssant, preferably desipramine...
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5719180 |
Chroman derivatives having vitamin E-like activities
Described herein is a chroman derivative represented by the following formula: ##STR1## wherein X represents H, --CH 2 OH, --CHO, --COOH, --COOCH 3 , --CHNOH, --CONH 2 , --COCH 3 , --CH(OH)CH 3...
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5719186 |
Amide derivatives and their therapeutic use
Novel carbocyclic amides together with their salts, solvates and physiologically active derivatives which have a number of uses in medicine, in particular as central muscle relaxants, and in the...
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5712305 |
Antineoplastic cocoa extracts and methods for making and using the same
Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants....
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5708020 |
Arylalkyl(thio)amides
A compound which is selected from those of formula (I) : ##STR1## in which A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description, its optical isomers, and its addition salts...
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5708012 |
Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus
Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations exhibiting insulin resistent non-impaired glucose tolerance (IRNIGT) in order to prevent...
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5705501 |
Certain substituted 1-aryl-3-morpholinopropanones to treat Alzheimer's Disease
Disclosed are compounds of formula I: ##STR1## wherein X is selected from oxygen, sulfur and NR; wherein R is selected from hydrogen, loweralkyl and CH 2 CH 2 COAr 1 ; and Z is hydrogen;...
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5703113 |
Benzopyran derivatives
The invention relates to benzopyran compounds of formula (I) possessing pharmacological activity, as well as to pharmaceutical compositions containing the compounds of formula (I) and processes for...
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5703115 |
(benzodioxan, benzofuran or benzopyran) alkylamino! alkyl substituted guanidines
The present invention is concerned with vasoconstricive benzodioxan, benzofuran or benzopyran)alkylamino!alkyl substituted guanidines having the formula ##STR1## the pharmaceutically acceptable...
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5703118 |
Use of benzopyran derivatives for the treatment of pathologies associated with the NA.sup.+ -independent CI-/HCO.sub.3 -exchanger
A method of treating a mammal afflicted with a disorder associated with the Na + -independent Cl - /HCO 3 - exchanger comprising the step of administering a compound selected from those of...
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5700396 |
Cosmetic compositions and an emulsion composition
A cosmetic composition and an emulsion composition respectively comprising 0.1 to 99 weight % of an oily component and 99.9 to 1 weight % of a watery component are are provided and the oily...
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5695652 |
Methods for inhibiting the production of slime in aqueous systems
Methods for inhibiting the attachment of microbes to surfaces in aqueous systems are disclosed. Tea extracts and/or tannins are added to aqueous systems, such as papermaking and cooling water...
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5691172 |
Cosmetic composition containing as colorant at least one 5-methoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one derivative
A cosmetic composition containing at least one derivative of 5-methoxy 8-methyl 2-phenyl 7H-1-benzopyran-7-one, the method of preparing these derivatives, and novel derivatives are disclosed. The...
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5691379 |
Dihydrolipoic acid as an ophthalmological agent to suppress intolerance reactions in the area between implants and living body tissue
Pharmaceutical compositions comprising dihydrolipoic acid or physiologically acceptable salts thereof are disclosed for the treatment of eye diseases and intolerance reactions in the area between...
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5688777 |
Inhibition of C. difficile infections by indigestible oligosaccharides
The primary etiology of antibiotic-associated diarrhea (which may lead to pseudomembranous colitis) has been recognized as Clostridium difficile. It is believed that the indigenous microflora of a...
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5686486 |
4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections
The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected...
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5686485 |
Physiologically active EI-1941 compounds
The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R 1 and R 2 is hydrogen and...
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5684038 |
Composition and process for prevention and treatment of cutaneous immediate hypersensitivity reactions
A process and pharmaceutical composition for the prevention and treatment of cutaneous Type I hypersensitivity reactions in humans is disclosed. The pharmaceutical composition comprises of a...
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5684031 |
Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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5684041 |
Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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5679706 |
Combination of a potassium channel activator and an antiarrhythmic agent
A method for the concomitant treatment of ischemia and arrhythmia in mammalian species which includes administering a combination of a potassium channel opener having little or no effect on action...
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5674871 |
Iontophoretic delivery of an antimigraine drug
The present invention relates to the iontophoretic delivery to a patient, more in particular to a migraine patient, of a compound of formula (I) as shown hereinunder. The invention also relates to...
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5670538 |
Use of prodelphinidins for obtaining medicaments intended for the treatment of arthrosis
A subject of the invention is the use of prodelphinidins for obtaining medicaments intended for the treatment of articular pathologies associated with the destruction of the cartilage, and more...
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5670154 |
Reducing tyrosinase activity
A tyrosinase inhibiting agent acts specifically on tyrosinase to inhibit it; the effective component of this action being an inhibitor of tyrosinase consisting of tea polyphenols.
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5670518 |
Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
Unsubstituted or substituted halo nitro and nitroso compounds and their metabolites are potent, selective and non-toxic inhibitors and supressants of cancer growth and viral infections in a...
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5661166 |
Saishin N compounds, process for preparing same and antiulcer agents containing same
A Saishin N derivative represented by the following general formula: ##STR1## wherein X represents a carbonyl group or a >CH--ORx group, or X bonds to a carbon atom in Y or Z to represent a...
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5658941 |
Aminomethyl-benzodioxane and benzopyran serotonergic agents
Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.
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5656658 |
Method for the treatment of anxiety
A method is disclosed for the treatment of anxiety by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.
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5656657 |
Chroman derivatives
3-amino-5-carbonylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are...
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5654296 |
Condensed heterocyclic compounds, their production and use
The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R 1 and R 2 independently represent hydrogen, acyl or hydrocarbon group or R 1 and R 2 ...
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5650432 |
Method of treating or preventing non-viral microbial infection
Proanthocyanidin monomers, dimers, polymers, flavonoid, and flavanoid derivatives and related compounds are used for their ability to interfere with bacterial adherence to a surface. Crystalline...
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5648377 |
Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
The present invention relates to novel formulations and combinations of lipophilic and hydrophilic antioxidants and the use thereof in the therapeutic, foodstuff, dietetic, and cosmetic fields....
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5648378 |
2-iminochromene derivatives as inhibitors of protein tyrosine kinase
Protein tyrosine kinase inhibitors are provided of formula (I): ##STR1## wherein R 2 is H, OH, halo or O(C 1 -C 4 )alkyl; R 2 is OH, halo or O(C 1 -C 4 )alkyl; R 1 is ##STR2## wherein R 4 is...
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5646178 |
Cranberry extract and biologically active compounds derived therefrom
Compounds isolated from plant materials of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, are described. The specific...
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5643943 |
Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
Methods for treating vascular inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and...
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5643921 |
Cardiopulmonary bypass and organ transplant using a potassium channel activator
In accordance with the present invention novel methods for cardiopulmonary bypass and organ transplant, each employing a potassium channel activator, are disclosed. The use of a potassium channel...
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5643942 |
Methods, composition and solutions for treating alopecia
This invention relates to the method for treating the form of alopecia commonly known as "male pattern baldness" which comprises regular topical application to the affected areas of the human scalp...
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5641807 |
Method for the treatment of depression
A method is disclosed for the treatment of depression by the administration of 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.
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5639785 |
Methods for the treatment of baldness and gray hair using isoflavonoid derivatives
The present invention relates to novel pharmaceutical compositions of isoflavanoid derivatives useful for the treatment of male pattern baldness and alopecia areata, and their use in promoting the...
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5639784 |
Method for the treatment of migraine
A method is disclosed for the treatment of migraine by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.
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5637624 |
Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor.
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5629339 |
Diosmetin compounds
Disclosed herein are new diosmetin compounds of formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description. The said compounds are useful in the treatment of...
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5629321 |
Bicyclic compound and platelet aggregation inhibitor containing the same
The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet...
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5627205 |
Substituted phenoxyisobutyric acids and esters
New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Z are as...
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