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7615664 |
Phenyloctanamides
Compounds of the general formula (I) in which the substituents R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each as defined in claim 1 have renin-inhibiting properties and can be used as...
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7601712 |
Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
A compound represented by formula (I)
wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP...
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7589232 |
Alkynyl aryl carboxamides
The present invention is related to alkynyl aryl carboxamides of Formula (I′) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders...
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7531695 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
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7521474 |
Biologically active lasonolide compounds
The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of...
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7514461 |
Chroman derivatives
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I
wherein the substituents are as defined in the specification. They are...
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7507762 |
Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
wherein A, B, X, Y, Z and R 5 are defined herein. The present invention...
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7498359 |
Composition and method for preventing recurrence of stroke
By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in...
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7495025 |
Spiro-1,2,4-trioxanes
The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes.
...
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7485326 |
Oral microemulsion composition comprising biphenyldimethyldicarboxylate and silybin
A microemulsion composition comprising biphenyldimethyldicarboxylate (BDD) and silybin or a derivative thereof, or a <i> Carduus marianus </i> extract containing silybin and derivatives...
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7476690 |
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of...
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7456213 |
PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions
This invention relates to graft copolymer delivery vehicles comprising a polyethyleneglycol-poly(ortho ester), and to controlled release pharmaceutical compositions comprising the delivery vehicle...
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7423062 |
Insecticidal composition
An insecticidal composition which comprises an ester compound given by formula (1):
[wherein R represents a methyl or methoxymethyl group]
and 2,4,6-triisopropyl-1,3,5-trioxane as active...
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7419986 |
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
Compounds of the Formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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7384919 |
Increased solubility flavanolignan preparations
The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on...
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7354950 |
1,3-Dioxane derivatives, composition, optical element and display device containing the same
A composition includes at least one compound represented by the following Formula (1). In the Formula (1), R 1 represents an alkyl group having 1 to 18 carbon atoms, R 2 represents a hydrogen...
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7307043 |
Aqueous neonicotinoid compositions for seed treatment
An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one...
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7291644 |
Indole derivatives
Compounds represented by formula (I)
wherein all symbols represent the same meanings as described in specification and salts thereof.
Since the compound represented by the formula (I) binds...
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7265130 |
NPY Y5 antagonist
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I):
wherein R 1 is lower alkyl, cycloalkyl or the...
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7259170 |
Macrolides containing pharmaceutical compositions
A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s).
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7256218 |
Biguanide and dihydrotriazine derivatives
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine...
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RE39593 |
1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects
1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I
a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical...
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7183314 |
Compound for treatment of anxiety and methods of preparation and use thereof
A method for preventing or for treating anxiety in a patient in need thereof comprising administering wogonin to the patient in an effective dose that does not cause sedative or myorelaxant side...
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7166622 |
Substituted phenylsulfonamide inhibitors of beta amyloid production
Compounds of Formula I,
wherein R 1 –R 8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these...
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7157454 |
Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same
The invention relates to compounds of formula:
These compounds show affinity for the bradykinin receptors with selectivity towards the B 1 receptors; they may be used for the preparation of...
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7153885 |
Stolonoxides
Naturally occurring stolonoxide compounds, and derivatives thereof, have antitumor activity. Typical compounds are of the formula (I) or a derivative thereof
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7135495 |
Indole derivatives
Compounds represented by formula (I)
wherein all symbols represent the same meanings as described in specification. and salts thereof.
Since the compound represented by the formula (I) binds...
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7135479 |
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
Compounds of the Formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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7119116 |
Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
A compound corresponding to general formula (I):
in which R 1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C 1...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7101912 |
Carbidopa prodrugs and derivatives, and compositions and uses thereof
Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and...
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7101908 |
Bicyclic carbohydrate compounds useful in the treatment of infections caused by herpesviridae
Bicyclic carbohydrates for the treatment of infections caused by herpseviridae, and in particular cytomegalovirus. The invention consists of the novel bicyclic carbohydrates the generic structure...
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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7071226 |
Amino-functionalized 1,2,4-trioxanes useful as antimalarial agents and process for preparation thereof
The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4
wherein Ar represents aryl groups such as phenyl, 4-biphenyl,...
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7067315 |
Identification of anti-protozoal agents
The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to...
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7060727 |
Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
The present invention relates generally to prodrugs of fused GABA analogs, pharmaceutical compositions of prodrugs of fused GABA analogs, methods of making prodrugs of fused GABA analogs and...
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7053116 |
Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing...
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7022732 |
Propanolamine derivative having 1, 4-benzodioxane ring
This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof:
The present...
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7015244 |
Inhalable chemical debridement for COPD
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.
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7012091 |
Inhalable inhibitors of inflammation in the respiratory tract
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation to inhibit inflammatory responses in the respiratory tract are disclosed.
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7001905 |
Substituted diarylamines as MEK inhibitors
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; X is OR 12 , NR 13 R 12 , or NR 14 ; inhibitors of MEK and...
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6962931 |
Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors
CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are...
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6951882 |
Substituted 4-phenyl-[1,3]-dioxanes
Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder...
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6924306 |
Method for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraoccular pressure in the...
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6916844 |
Hydroxy pyranone derivative and preparation method thereof
The present invention provides hydroxy pyranone derivatives and a method for preparing the hydroxy pyranone derivatives. The hydroxy pyranone derivatives of the present invention are significantly...
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6911432 |
Drugs, foods or drinks with the use of algae-derived physiologically active substances
Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I):
These compositions include foods,...
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6906098 |
Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof
Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1
wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or...
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6890955 |
Aryloxypropanolamine derivatives, method of preparation and applications thereof
The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and...
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6864282 |
9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma
9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin...
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6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
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