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7622499 |
β-Benzyloxyaspartate derivatives with photosensitive groups
The present invention relates to photosensitive derivatives of optically active L-threo-β-benzyloxyaspartate or its benzene ring-substituted analogs, represented by the following formula (1) or...
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7622498 |
Sugar derivatives comprising oxiranes or α, β-unsaturated δ-lactones, process for their preparation and their utilisation as pesticides
Pesticidal compounds of general formula (I)
Wherein represents a double bond; A— represents ═C(R 5 )—C(═O)—, wherein R represents hydrogen or halogen, R 1 and R 2 represent,...
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7618996 |
Diaryl ether derivatives and uses thereof
Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such...
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7595327 |
Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase
This invention provides compounds of Formula I, having the structure:
that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA),...
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7582675 |
Flavonoid compound and process for producing the same
A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial...
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7569594 |
Analogs of leucascandrolide A
The present invention describes leucascandrolide analogs of the formula (I), intermediates of the formula (III), pharmaceutical compositions containing the same, methods for preventing cell...
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7531521 |
Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is...
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7501541 |
Malonamides as orexin antagonists
The present invention relates to compounds of formula I
wherein
Ar 1 , Ar 2 , R, R 1 , R 2 , R 3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically...
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7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
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7485752 |
Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7479502 |
2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these...
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7417039 |
Use of substituted azetidinone compounds for the treatment of sitosterolemia
The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid...
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7410998 |
Inhibitors of NADH:ubiquinone oxidoreductase
Benzopyran-based inhibitors of NADH:ubiquinone oxidoreductase for inhibiting the growth of cancer cells.
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7399783 |
Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids...
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7381731 |
Pharmaceutical composition comprising citrulline
Embodiments of the present invention include compositions and pharmaceutical compositions comprising citrulline and Hmg-CoA reductase inhibitors. Further embodiments relate to the use of such...
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7368469 |
Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic...
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7354945 |
2-oxadiazolechromone derivatives
Novel compounds of the formula I
in which
R, X and n are as defined herein,
are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7300953 |
Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound
The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2):
wherein R...
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7261769 |
Stabilized anthocyanin extract from Garcinia indica
A method of making a red pigmented composition is disclosed which includes (a) preparing an aqueous extract of Garcinia indica fruit comprising at least one red colorant; (b) treating the extract...
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7256158 |
2,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides
The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I)
in which
Het represents one of the groups
wherein A, B, D, G, X, Y and Z have the meaning given in the...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7205333 |
Multivalent neuraminidase inhibitor conjugates
The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking...
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7192982 |
Modulators of peroxisome proliferator activated receptors
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH 2 — or —CH 2 CH 2 —; W is a substituted or...
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7192940 |
Ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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7183314 |
Compound for treatment of anxiety and methods of preparation and use thereof
A method for preventing or for treating anxiety in a patient in need thereof comprising administering wogonin to the patient in an effective dose that does not cause sedative or myorelaxant side...
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7157421 |
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula
where R 1 is H, C 1 –C 4 alkyl and OH; R 2 in is H, C 1 –C 4 alkyl and OH; R 3 is H and C 1 –C 4 alkyl; R 4 is H and C 1 –C 4 alkyl; n is an integer...
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7141605 |
Method of controlling animal pests and disinfecting inanimate surfaces
A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to...
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7141602 |
Process for obtaining HMG-CoA reductase inhibitors of high purity
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The...
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7138429 |
Flavonoid compound and process for producing the same
A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial...
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7125853 |
Bicyclic carbohydrate compounds useful in the treatment of infections caused by Flaviviridae sp., such as hepatitis C and bovine viral diarrhea viruses
We describe the use of bicyclic carbohydrates for the treatment of hepatitis C virus infections. Different bicyclic carbohydrates were tested in vitro against DNA-viruses, retro-viruses and ...
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7119085 |
Methods to treat alzheimer's disease
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII)
useful in treating Alzheimer's disease and other similar diseases.
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7101907 |
Topical administration of statins for treatment of bone disorders
The topical administration of statins for the treatment of bone disorders is disclosed.
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7053109 |
Aminediols for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7048940 |
Alpha-pyrone compositions for controlling craving and as a substitute for alcohol
Administered anticraving compositions are disclosed for treating patients addicted to alcohol comprising an effective amount of at least one alpha-pyrone compound formulated into a physiologically...
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7037936 |
Compounds useful for the treatment of cancer, compositions thereof and methods therewith
The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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RE39061 |
Pharmaceutical formulations comprising labdanes for the treatment of tumors or leukemias
The present invention relates to novel compositions based on hydrated lipidic lamellar phases or liposomal compositions, prepared by combining different lipid molecules, synthetic and/or from...
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7015244 |
Inhalable chemical debridement for COPD
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.
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6962931 |
Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors
CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are...
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6960573 |
Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same
Compounds expressed by the following general formula (1),
[wherein, R 01 and R 02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the...
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6939892 |
Compositions for treating or preventing malaria and method of treating malaria
An antibiotic SF2487 substance having the formula (I)
or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an...
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6939859 |
Skin preparations for external use
An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1)
(wherein R 1 , R 2 , R 3 , and R 4 which may be the...
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6927217 |
HIV protease inhibitors
The present invention relates to novel dihydropyrones of Formula I
wherein X is NH or NR 8 , which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in...
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6916831 |
Flavone acetic acid analogs and methods of use thereof
Compounds are described having a structure according to Formula I or Formula II:
wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O...
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6908902 |
Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin
Co-therapy for the treatment of neurological dysfunctions comprising administration of one or more fructopyranose sulfamates and erythropoietin.
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6890937 |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix...
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6884783 |
7-Hydroxy chromones as potent antioxidants
The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for...
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6844363 |
Hydrates of a neuraminic acid compound and crystalline forms thereof
Hydrates of the compound of formula (I) and crystalline forms thereof have excellent storage stability and are useful medicaments.
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