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6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
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6403347 |
HIV integrase inhibitors
Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of...
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6403645 |
Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them
Norepinephrine uptake 2 inhibitors (or their precursors) are administered to enhance the effect of norepinephrine reuptake inhibitors and other antidepressants. The uptake 2 inhibitor may be...
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6384072 |
Benzocycloheptene derivatives
This invention relates to benzocycloheptene derivatives having novel structure. More particularly, it relates to new benzocycloheptene derivatives and pharmaceutically acceptable salts thereof,...
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6380227 |
Fermentative preparation process for and crystal forms of cytostatics
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new...
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6380200 |
Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
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6380244 |
Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers
Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers...
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6376535 |
Oxygen-containing heterocyclic compounds
The present invention relates to oxygen-containing heterocyclic compounds represented by the following formula (I): wherein m represents an integer of 0 to 4; R 1 , R 2 , R 3 and R 4 ...
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6362218 |
Brefeldin A derivatives
Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited...
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6362168 |
Antiparasitic agents
Compounds of the formula: wherein X represents a single or a double bond; R 1 is H or OH; provided that when X is a single bond, R 1 is H or OH, and when X is a double bond, R 1 is absent; R...
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6362219 |
Process for the preparation of a formulation of dihydroartemisinin for the control of wide spectrum of malaria
The present invention relates to a synergistic formulation useful for the control of wide spectrum of malarial infections, which comprises a pharmaceutically effective amount of dihydroartemisinin...
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6355674 |
Aminotetralins as 5-HT1D α Agonists
A class of novel aminotetralins is disclosed useful as 5-HT 1Dα agonists.
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6355634 |
Aromatic compounds
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
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6353019 |
Macrocyclic lactones, compositions, and methods of use
The present invention provides compound of the formula: wherein R 1 and R 2 are the same or different and are independently H, C 1 -C 6 straight-chain or branched saturated or unsaturated...
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6346527 |
Guanidine derivatives
A compound of the formula: wherein R 1 is hydrogen or halogen, R 2 is hydroxy, acyl(lower)alkoxy, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, lower alkylthio(lower)alkyl, mono(or di or...
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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6342520 |
Locally injectable chemotherapeutics
Sesquiterpenoid compounds and method for using such compounds to inhibit proliferation of malignant cells without inducing appreciable systemic cytotoxicity are disclosed. The compositions and...
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6340704 |
Cell differentiation inducing amide derivatives, their production and use
The present invention provides a compound represented by the formula: wherein R 1 is an amino group which may be substituted; R 2 is a hydrogen atom or a lower alkyl group which may be...
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6340671 |
Stable compositions for parenteral administration and their use
The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249α-λ compounds, 23-oxo or 23-imino...
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6333058 |
Process for the preparation of a spermicidal agent
A process for preparing a spermicidal agent from neem oil includes (a) mixing neem oil with an aliphatic hydrocarbon solvent so that a precipitate forms, and filtering the mixture to separate the...
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6326394 |
Calixarene tubes as cation receptors
A cyclic compound of formula (I) ##STR1## wherein R x groups which may be the same or different are selected from --O--(CH 2 ) n --O-- where n is an integer of from 2-6; R y and R z groups...
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6323238 |
Benzopyranyl guanidine derivatives, process for preparation thereof, and pharmaceutical compositions containing them
The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The...
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6323237 |
Therapeutic compositions
Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i)...
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6316437 |
Spirohydantoin compounds and uses thereof
Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One...
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6306819 |
Method for regulating size of vascularized normal tissue
Angiogenesis inhibitors are administered to patients in an amount effective to regulate normal, non-transformed vascularized tissue size and/or growth by regulating its vascular compartment....
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6306896 |
Pharmaceutically active composition containing artemisinine and/or derivative of artemisinine
The invention relates to a pharmaceutically active composition containing a substance which is active against malaria parasites and shows a high level of activity against multiresistant lines of...
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6300371 |
Rameswaralide and rameswaralide derivatives
A diterpene derivative compound, having the formula I, II, or III, compositions, and therapeutic compositions containing the compounds are disclosed. Also disclosed are methods for treating an...
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6294526 |
Use of flavone derivatives for induction of β-lactam-sensitivity of MRSA
A novel screening system for detecting a non-antibiotic compound having β-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a β-lactam antibiotic two times serially...
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6294570 |
Endosulfan microcapsule dispersion
Aqueous endosulfan microcapsule dispersions in which the dispersed microcapsules comprise endosulfan, an organic solvent or solvent mixture and a capsule-forming material based on isocyanate...
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6291515 |
Use of efomycins
The present invention relates to the use of known efomycins and elaiophylins for the treatment of autoimmune disorders, to new natural substances efomycins M and T, and processes for their...
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6288058 |
Substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
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6284797 |
Topical treatment of pain and to promote healing
A topical therapeutic preparation includes capsaicin which is an extract of peppers or chiles and which is a potent local pain killer. The ointment also includes a norepinephrine inhibitor and...
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6277889 |
Molluscicide formulation
A molluscicide containing a non-toxic animal repellant and metaldehyde, in which the molluscicidal efficacy of the molluscicide greater than that of the molluscicide if it did not contain...
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6274600 |
Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors
Compounds ##STR1## are useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof and methods for their use for treatment of...
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6245806 |
HIV integrase inhibitors
Novel tetracyclic aromatic ketones are natural product compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as...
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6224895 |
Method for promoting ovulation, parturition, and lactation in mammals
The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a...
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6221377 |
Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
Administration mediums comprising solutions of nitrous oxide in water, alcohols, ethers or oils, and optionally including essential fatty acids or C 1 -C 6 alkyl esters thereof enhance the action...
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6214864 |
Formulation of dihydroartemisinin for the control of wide spectrum of malaria
The present invention relates to a synergistic formulation useful for the control of wide spectrum of malarial infections, which comprises a pharmaceutically effective amount of dihydroartemisinin...
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6214865 |
Macrocyclic analogs and methods of their use and preparation
The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained...
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6211229 |
Treatment of transient and short term insomnia
The invention is directed to a method for the treatment of a patient suffering from transient or short term insomnia. The claimed method comprises the administration of a compound selected from the...
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6211228 |
Compositions and methods for treating mast-cell mediated conditions
Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are...
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6211171 |
Use of antidepressants for local analgesia
When administered locally, tricyclic, second generation and third generation antidepressants, such as amitriptyline and desipramine, have been shown to produce analgesia in a subject having a site...
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6197830 |
Method for achieving relief from sympathetically mediated pain
A method is presented whereby sympathetically mediated pain relief is achieved through the periodic topical administration of compositions comprising tricyclic antipressants mixed with one or more...
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6194405 |
Method of using substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
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6180659 |
Tracheal smooth muscle relaxant
The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective...
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RE37035 |
Phenylacetic acid benzylamides
Phenylacetic acid benzylamides having the following general structure ##STR1## wherein the substituents are defined herein, are disclosed, which compounds are hypoglcemic agents.
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6180105 |
Method for producing an extract containing artemesinin
A method of preparation of an artemisinin extract comprising the steps of extraction of Artemisia annua with liquid carbon dioxide and allowing the carbon dioxide to evaporate from the resultant...
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6174914 |
Method of inhibiting cytokine release from human ocular cells
Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepi
n-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for...
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6174880 |
Method for treatment of painful fibromuscular disorder
A method for treating painful fibromuscular disorders comprising topical application to the skin of a therapeutically effective amount of a tricyclic antidepressant compound in a pharmaceutically...
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