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6710089 |
Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6710074 |
Compound having antimalarial activity
An object of the present invention is to provide a novel compound having antimalarial acitivity and an antimalarial agent containing the novel compound as an active component. An antimalarial agent...
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6696483 |
Inhibitors of angiogenesis and tumor growth for local and systemic administration
The invention provides pharmaceutical formulations and methods for the treatment of individuals suffering from a condition, disease, or disorder that is treatable by the inhibition of angiogenesis....
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6685972 |
Process for isolating artemisinin from Artemisia annua
The present invention relates to a process for the isolation of artemisinin, an antimalarial agent from the herb of the Artemisia annua plant, comprising of extracting the herb with ethanol,...
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6680055 |
Mycolactone and related compounds, compositions and methods of use
The present invention provides, inter alia, polyketide macrolides including a polyketide macrolide of the structure wherein R 1 -R 5 are the same or different and each is independently selected...
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6677370 |
Compositions and uses of dictyostatin compounds
Dictyostatin-1 has been found to stabilize microtubules and prohibit their depolymerization to free tubulin. Because of these activities, the dictyostatin compounds can be used in the treatment of...
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6670348 |
Methods and compositions for destruction of selected proteins
Compounds having an ansamycin anitibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective...
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6667338 |
9-amino erythromycin derivatives with antibacterial activity
Compounds of formula (I) and formula (II) or therapeutically acceptable salts or prodrugs thereof are useful as antibacterial agents. Methods to make the compounds, compositions containing the...
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6663879 |
Injectable compositions
A stable injectable composition includes a non-aqueous parasitic agent in a therapeutically effect amount, chosen from the group of avermectin, ivermectin, doramectin, abamectin, milbemycin and...
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6660765 |
FC101 as a method of treatment for cancer
The present invention provides a treatment for angiogenic diseases, including solid tumors. The treatment consists of administering therapeutically active dosages of FC101, resulting in a reduction...
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6653342 |
13-substituted milbemycin derivatives, their preparation and their use against insects and other pests
Compounds of formula (I) and salts thereof: Wherein R 1 represents methyl, ethyl, isopropyl or s-butyl; and R 2 represents hydrogen or alkyl. R 3 represents hydrogen, optionally substituted...
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6649647 |
Trioxane derivatives
This invention relates to compounds containing a trioxane moiety, especially certain artemisinin derivatives, which have cytotoxic and antitumour activity and their use in the treatment of cancer....
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6649630 |
Methods and compositions controlling pests
The present invention provides compositions and methods which can provide a pesticidal effect. The compositions typically comprise 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether and an ether compound...
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6646000 |
Method to control plant pests, improve plant productivity and other purposes
A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to...
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6635662 |
Radicicol derivatives
Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R 1 and R 2 are the same or...
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6635671 |
Compounds which affect mRNA stability and uses therefor
Compounds which induce degradation of mRNA which contains one or more mRNA instability sequences are provided for use as pharmaceuticals, e.g. for use in the prophylaxis or treatment of diseases...
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6630506 |
Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 0 to 4; X is a bond, O, S, SO, SO 2 , CO, or NR 7 ; Y is a bond, O, S, SO,...
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6624189 |
Byrostatin analogues, synthetic methods and uses
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or imroved recognition domains are disclosed, including methods of preparing and...
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6610736 |
16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use
The invention relates to novel epothilone derivatives of general formula (I), wherein R 8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the...
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6596758 |
Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R 1 , R 2 and (R) p have the meanings as given in claim 1, which can be used in the treatment of...
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6593347 |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
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6589948 |
Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases
This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase...
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6586425 |
Cytoskeletal active agents for glaucoma therapy
Methods for the treatment of glaucoma are provided by the present invention. The compounds described cause a perturbation of the actin cytoskeleton in the trabecular meshwork or the modulation of...
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6586407 |
Injectable pharmaceutical formulations for partricin derivatives
New injectable pharmaceutical formulations are described, containing a partricin derivative in the form of a free base as the active ingredient, or a pharmaceutically acceptable water-soluble salt...
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6586464 |
Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same
Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and...
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6573295 |
Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a...
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6566391 |
Trioxepan compounds
The invention relates to compounds of formulae I and II and compositions comprising these compounds.
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6559178 |
Compositions and methods for apoptotic chemosurgery
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to achieve apoptotic ablation of internal organs or internal non-malignant cell populations are disclosed.
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6552089 |
Method of treating or preventing alopecia
The present application discloses a method of treating alopecia which is based on the use of a tellurium compound such as ammonium trichloro(dioxoethylene-O,O-tellurate).
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6545038 |
Heterocyclic metalloprotease inhibitors
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide,...
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6541038 |
Method for treating wood with a metal-containing treating agent and wood treated thereby
A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion...
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6531460 |
Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same
Compounds expressed by the following general formula (1), The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid...
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6528489 |
Mycotoxin derivatives as antimitotic agents
The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic...
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6518302 |
Remedies
Compounds represented by general formula (I) wherein X represents OH or OSO 3 H; and R represents a substituent other than OH which allows, after leaving, the induction of unsaturated bonds into...
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6495591 |
Fungal efflux pump inhibitors
The use of compounds of the milbemycin class as inhibitors of efflux pumps in microbes or other cells is described, along with pharmaceutical compositions incorporating a milbemycin. Also described...
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6495593 |
Compositions for preventing or treating adverse physiological effects associated with cardiac disease
A method is disclosed for preventing or treating the adverse physiological effects associated with cardiac disease by administering a purified proanthocyanidin composition to the person in an...
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6495592 |
Tracheal smooth muscle relaxants
The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient.
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6486195 |
Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic...
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6479537 |
Synergistic ectoparasiticidal methods and compositions
The present invention provides methods for synergistic control of ectoparasitic arthropods with a synergistically effective amount of a combination of the macrocyclic lactone moxidectin and an...
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6461603 |
Water-soluble polymer conjugates of artelinic acid
The present invention provides water-soluble polymer conjugates of the anti-malarial drug, artelinic acid, using water soluble and non-peptidic polymer backbones, such as poly(ethylene glycol). The...
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6455576 |
Macrolides with anti-inflammatory activity
3′-Des-dimethylamino-9-oxyimino macrolides of formula (I) endowed with anti-inflammatory activity and their pharmaceutical use are described.
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6444230 |
Synergistic composition of peracetic acid and amine oxide
Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid,...
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6444690 |
Insecticidal compositions
The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) in which R 1 represents C 1 -C 5 -alkyl, R 2 represents hydrogen or C 1 -C 5 -alkyl or...
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6440469 |
Plant protein for nutritional products and method of making same
The present invention relates generally to a method of producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese or nucleotides. More...
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6441027 |
Method of regulating the female reproductive system through angiogenesis inhibitors
A method of inhibiting angiogenesis in a female mammal to regulate fertility comprising administering to the female mammal an effective amount of an angiogenesis inhibiting compound. In addition, a...
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6429202 |
Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more...
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6423741 |
Anti-microbial composition and method for producing the same
This invention is related to the development of strategic and novel composition comprising α arteether and nalidixic acid or quinolone drugs, said composition useful as an advanced generation drug...
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6416752 |
Termite bait composition and method
An improved termite bait composition comprises a powdered cellulosic attractant having a particle size in the range of approximately 1 to 100 micrometers and a termite killing agent. Also disclosed...
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6410567 |
Pesticide containing a photosensitizer and an attractant
The present invention relates to a new pesticide which is based on a photosensitizer or combination of photosensitizers of the tetrapyrrole and/or tetraazapyrrole series which may comprise a...
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6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
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