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7176235 |
Epothilone derivatives and methods for making and using the same
This invention relates to compounds of formula (I)
and to pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , W, X, Y, and Ar are as defined herein....
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7166583 |
1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
The present invention relates to 1,3-diaza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well...
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7160898 |
Pharmacological treatment for sleep apnea
The present invention relates to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess...
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7151116 |
Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof;...
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7144866 |
Avermectin derivatives
Provided is a compound represented by the general formula (I) or a salt thereof:
wherein, —X Y— represents —CH═CH— and the like, between R 2 and the carbon atom at 5-position...
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7144885 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
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7141605 |
Method of controlling animal pests and disinfecting inanimate surfaces
A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to...
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7122335 |
Compounds and methods to enhance rAAV transduction
Agents and methods to alter rAAV transduction, including agents and methods to enhance rAAV transduction, are provided. For instance, the invention provides methods to identify agents that enhance...
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7122537 |
Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases
This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase...
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7115651 |
Macrocycles and uses thereof
The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof)
wherein R 0 –R 4 , Z, X, A—B, D—E, G—J, and K—L are as...
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7109235 |
Microtubule stabilizing compounds
Laulimalide and epothilone derivatives useful as microtubule stabilizing agents, and in the treatment of cancers are disclosed. Methods of making the compounds and using the compounds as...
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7101912 |
Carbidopa prodrugs and derivatives, and compositions and uses thereof
Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and...
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7098242 |
Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial...
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7084176 |
N-arylphenylacetamide derivatives and medicinal compositions containing the same
N-Arylphenylacetamide derivatives represented by the following formula [I]:
(wherein R 1 is C 1-6 alkoxy, etc.; R 2 is hydrogen, —(CH 2 ) m —N(R 6 )(R 7 ) (m is an integer of from 1 to...
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7081474 |
Drugs to improve synaptic transmission
Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal issues.
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7067315 |
Identification of anti-protozoal agents
The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to...
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7053109 |
Aminediols for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7029706 |
Composition for the treatment of cutaneous mycosis
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and...
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7026352 |
Physiologically active substances
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide...
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7015244 |
Inhalable chemical debridement for COPD
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation for chemical debridement of cells in the lungs of COPD patients are disclosed.
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7012091 |
Inhalable inhibitors of inflammation in the respiratory tract
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds by inhalation to inhibit inflammatory responses in the respiratory tract are disclosed.
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6982280 |
Epothilone derivatives, a method for the production thereof, and their use
The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents.
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6982252 |
Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents
The present invention relates to methods and compositions for inhibiting cell survival and/or promoting cell death following exposure to cytotoxic agents and stress such as radiation or...
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6960573 |
Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same
Compounds expressed by the following general formula (1),
[wherein, R 01 and R 02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the...
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6946482 |
Motilide compounds
Motilide compounds having the formula (I),
wherein R 1 , R 2 , R 3 , and R 4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions...
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6946456 |
Methods for treating cell proliferative disorders and viral infections
The present invention concerns methods for treating cell proliferative diseases, tumors associated with viral infections, and certain viral infections. The disclosed methods use compounds which...
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6936628 |
Oral administration of epothilones
The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have...
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6933318 |
Topical organic ectoparasiticidal formulations
This invention provides topical ectoparasiticidal fomulations comprising an ectoparasiticide, preferably a pyrethroid or a spinosyn, a spreading agent at is a (C 3 -C 6 ) branched alkyl (C 10 -C 20...
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6914051 |
Penetrating antibiotic gel for soft tissue diseases
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an...
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6911469 |
Sulfonamide compounds and pharmaceutical use thereof
A sulfonamide compound of the formula (I):
R 1 —SO 2 NHCO—A—X—R 2 (I)
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6881731 |
Enhancers for microbiological disinfection
Simple carboxylic acids, in particular dicarboxylic acids such as citric acid shows an unexpected ability to enhance the antimicrobial power of a wide range of disinfectant and/or antibiotic...
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6872747 |
Decalactones, method for making, and pharmaceuticals there from
A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the...
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6861442 |
PYK2 and inflammation
The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to...
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6855735 |
Ketamine treatment of restless legs syndrome
The present invention is directed to a method for treating symptoms associated with Restless Legs Syndrome (RLS). The method includes administering to a warm-blooded animal in need of such...
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6825229 |
Methods for Alzheimer's Disease treatment and cognitive enhancement
The present invention relates to compositions and methods to modulate α-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in...
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6821977 |
Antidiabetic agents
A compound of the formula whereon R 1 is: R 5 is: and n, m, Z, R 8 , R 9 , R 10 and R 11 are as defined herein, useful in the treatment of diabetes, insulin resistance, diabetic...
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6818667 |
Eurotinones, and derivatives thereof, processes for preparing them, and their use
The present invention relates to novel compounds of the formula I in which R(1), R(2), R(3) and R(4) are, independently of each other, hydrogen or an alkyl radical. The compounds of the formula...
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6815463 |
Laulimalide derivatives
Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
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6794376 |
Methods and compositions for enhancing diffusion of therapeutic agents through tissue
The present invention provides methods and compositions for enhancing the diffusion of therapeutic agents through mammalian tissue. In one embodiment, invention provides methods and compositions...
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6790863 |
Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial...
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6765016 |
Bicyclic ketolide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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6764996 |
9a-azalides with antibacterial activity
Compounds of formula (I) formula (II) formula (III) and formula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds,...
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6756402 |
Cyclipostins, process for their preparation and use thereof
The invention relates to compounds of formula I in which R 1 , R 2 , E, X 1 , X 2 , and X 3 have the meaning as described in the specification and claims, obtained by culturing Streptomyces...
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6746677 |
Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a...
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6727276 |
Epothilone derivatives for the treatment of refractory tumors
A method of treating tumors in a mammal, especially a human that have demonstrated resistance to oncology with taxane oncology agents is disclosed. The method is effective where the tumor has...
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6727278 |
Pharmaceutically active agents that impede amyloid formation in vivo
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation...
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6723753 |
Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6723731 |
Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Ar, X, Q, A, Y and Z are as defined in the specification. These compounds are...
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6713506 |
Tea polyphenol esters and analogs thereof for cancer prevention and treatment
Disclosed herein are ester-bond containing tea polyphenols that has a susceptibility to nucleophilic attack, their analogs and pharmaceutically acceptable salts, method for inhibiting proteasomal...
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