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4423063 |
2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C 1 -4 alkyl; and L is a lipophilic group consisting essentially of ##STR2## where R' is (a)...
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4411896 |
Rifamycins, their compositions and use as antibiotics
New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=>CO; R 1 =OH; R 2 =H), 3,31-dihydroxy-rifamycin S (formula A:...
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4395420 |
Method and composition for treating pruritis
A method of and composition for treating pruritis comprising topically applying a therapeutically effective amount of a tricyclic anti-depressant in a pharmaceutically acceptable carrier. The...
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4390546 |
Antiparasitic macrolide from a strain of Streptomyces hygroscopicus
There is disclosed a macrolide isolated from the fermentation broth of a microorganism identified as MA-5285 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The...
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4385065 |
Novel substances and process for their production
There is disclosed a novel series of compounds isolated from the fermentation broth of a strain of the microorganism Streptomyces sp MA5038. The compounds have a 16-membered macrocyclic lactone...
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4370342 |
S-Alkyl 3-alkylthiopropionothioate compounds, their production and their medicinal use
The invention relates to S-alkyl 3-alkylthiopropionothioates of Formula (I) as defined herein. Also included in the invention are methods for the manufacture of said S-alkylthiopropionothioates,...
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4367238 |
Phenyl-alkanoic acid derivative and preparation thereof
This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic...
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4356186 |
Acetic acid derivatives and composition containing the same
Novel acetic acid derivatives of the formula: ##STR1## wherein X is oxygen or sulfur; R 1 is hydrogen or a lower alkyl; R 2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a...
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4338316 |
9-Aryloxy prostane derivatives
The disclosure relates to 9β-aryloxy prostane derivatives, for example 16-(3-chlorophenoxy)-11α,15α-dihydroxy-16-methyl-9β-pheno
xy-18,19,20-trinor-5-cis,13-trans-prostadienoic acid, which...
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4337258 |
2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C 1 -4 alkyl; and L is a lipophilic group consisting essentially of (1) ##STR2## where R'...
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4335122 |
Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use
The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R 4 is a hydrogen or an alkyl; R 1 is hydrogen or...
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4324778 |
Pharmaceutical composition containing parcetamol
The acute liver toxicity effects of paracetamol are reduced by co-formulating with ascorbic acid derivatives (ascorbate anion bioprecursors) which produce high liver concentrations of ascorbate...
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4321257 |
Potentiated medicaments
Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal...
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4289785 |
Method and compositions involving prostaglandins
5-Oxa-17-phenyl-18,19,20-trinor-PGF 1 α alkyl esters and 5-oxa-17-phenyl-18,19,20-trinor PGF 1 α amide are combined with certain other prostaglandins in synergistic combinations to induce...
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4279905 |
1-Benzoxepin-5 (2H)-one derivatives and pharmaceutical compositions
Novel, 3-amino-1-benzoxepin-5 (2H)-one derivatives and methods for their production are disclosed. These derivatives correspond to the Formula I: ##STR1## wherein: R 1 and R 2 independently of...
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4261988 |
Chromanone derivatives
Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R 1 and R 2 independently denote radicals including hydrogen, alkyl, aryl and...
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4251526 |
2-Benzothiepins and compositions and methods of use therefore
Novel 2-Benzothiepins, having substituents in the 1-position heretofore unknown, are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them...
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4239772 |
Allyl and propyl zearalenone derivatives and their use as growth promoting agents
Resorcylic acid lactone compounds of the formula: ##STR1## wherein -A- is either --CH 2 --CH 2 -- or --CHCH; >Z is either >CH 2 , >C0 or >CH-OH; and R and R 1 are either H or a...
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4234598 |
Phenylcarbamates
Phenylcarbamates of the general formula: ##STR1## wherein R 1 is lower alkyl, lower alkenyl, lower alkynyl, lower alkylcarbonyl, halogen-lower alkylcarbonyl or trichloromethylsulfenyl and R 2 is...
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4232039 |
Phenyl- or cycloalkyl-benzo-oxacyclic compounds
The invention provides compounds of formula I, ##STR1## wherein R 1 is branched alkyl, cycloalkyl or phenyl, R 2 is hydrogen, methyl or halogen, X--Y is --CHR 3 CH 2 --, --CR 3 CH--...
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4205081 |
Composition and method for preventing or treating swine dysentery
A composition comprising one or more kinds of macrotetrolide antibiotic substances represented by the following general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are lower alkyl groups,...
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4197318 |
Potentiated antimicrobial medicaments
Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quaternary ammonium compounds, bisdiguanides, anti-fungal...
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4179516 |
Ethers of 3,4-dihydro-1-benzoxepin-5-one oxime to treat intestinal disorders
Therapeutic compositions, particularly for treating intestinal disorders, and a method of treating colopathics by administering an effective amount of the compositions are described. The...
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4176188 |
Utero-evacuants
Chemical compounds having a substituted oxepane ring and methods of preparing such compounds are described. The compounds are active as utero-evacuant agents.
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4169145 |
ω-Nor-cycloalkyl-13,14-dehydro-prostaglandins
ω-NOR-CYCLOALKYL-13,14-DEHYDRO-PROSTAGLANDIN COMPOUNDS, SPECIFICALLY 13,14-DEHYDRO-17-CYCLOHEXYL-20,19,18-TRINOR-PGF 2 α having antiulcer and luteolytic activity, are disclosed.
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4166865 |
Macrotetrolide animal growth promotor
A method for promoting the growth of domestic animals which comprises administering one or more kinds of macrotetrolide antibiotic substances represented by the general formula ##STR1## wherein R 1...
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4164584 |
Anti-leukemic trichothecene epoxides
There are provided novel anti-leukemic epoxides which are isolated from Baccharis megapotamica. The novel compounds are characterized by a 12,13-epoxytrichothecene central ring system which is...
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4156010 |
(R)-(-)-3-{[2-(P-hydroxyphenyl) -1-methylethyl]-aminomethyl}-3,4-dihydro-2H-1,5-benzodioxepin-3-ol
The isomer (R)-(-)-3-{[2-(p-hydroxyphenyl)-1-methylethyl]-aminomethyl}-
3,4-dihydro-2H -1,5-benzodioxepin-3-ol and its non-toxic acid addition salts is unexpectedly more potent in the reduction of...
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4144352 |
Milbemycin compounds as anthelmintic agents
The milbemycins are a known series of macrolides, which are disclosed as having insecticidal activity. These compounds have been discovered to have substantial anthelmintic activity. Compositions...
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4127668 |
Miticidal mixtures and method utilizing a macrotetrolide compound
Miticidal mixtures containing a macrotetrolide compound represented by the formula ##STR1## wherein R 1 , Rd 2, R 3 and R 4 are each selected from the group consisting of ethyl and ethyl, known...
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4117152 |
Oxofuranobenzoxepin-acetic acids, precursors and derivatives thereof
Oxofuranobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful...
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4107322 |
Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic acids
Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.
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4086358 |
Purification of utero-evacuant extracts from plant substances
Novel compounds obtained from the zoapatle plant and methods of obtaining these compounds from the plant material are described. The novel compounds possess useful activity as central nervous...
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4082850 |
Method of treating dermal inflammations
A method of treating dermal inflammation by topically administering to a patient an effective amount of a 6,11-dihydrodibenz[b,e]oxepinalkanoic acid, physiologically tolerable salt thereof,...
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4075331 |
Monoesters of rosamicin for eliciting an antibacterial response
Described herein are novel monoesters of rosamicin, also known as Antibiotic 67-694. Also described is a process for the preparation of such esters by the selective solvolysis of diester...
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4069339 |
Novel method for the depression of fat deposition in swine
There is provided a method for the depression of fat deposition in swine by administering to said swine an effective amount of the compound: 1H-2-benzoxacyclotetradecin-1-one,...
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4067991 |
Pharmaceutical compositions and method of use for prostaglandin 1,11- and 1,15-lactones
There are described pharmaceutical compositions comprising a lactone which is the 1,9-lactone, the 1,11-lactone, or the 1,15-lactone of a prostaglandin or prostaglandin analog in combination with a...
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4062970 |
Zearalin ethers
Novel zearalin ethers are disclosed, which are represented by the formula: ##STR1## wherein Y may be a single bond or double bond; A may be --CH 2 --, >CO, or >CHOR 1 ; R represents...
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4058626 |
Composition and method for killing snails and slugs
Compositions for killing slugs and snails, containing as the essential active ingredient metaldehyde and as an organoleptic denaturant benzyldiethyl-(2,6-xylylcarbamoylmethyl)-ammonium benzoate,...
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4035504 |
Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
A process, and the composition used therein, for estrogenic therapy which comprises administering daily to the patient from about 0.2 to 2000 milligrams of a compound having the formula: ##STR1##...
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4025640 |
Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof
Oxothienobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and process for their preparation are disclosed. These compounds are useful as...
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4004021 |
Cyclopentane derivatives
The disclosure relates to novel pentanor prostaglandin analogues, for example 15-(5-chloroindan-2-yl)-9α,11α,15-trihydroxy-16,17,18,19,2
0-pe ntanor-5-cis,13-trans-prostadienoic acid and...
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4001425 |
Methods of treating hypertension and pharmaceutical compositions comprising 1-tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents
This invention relates to methods of treating hypertension and pharmaceutical compositions comprising a class of 1-tertiary-alkyl-3-(substituted furyl)ureas that exhibit antihypertensive activity...
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3992551 |
Antisiotic substances B-41, their production and their use as insecticides acaricides
New antibiotic substances are obtained by culturing a strain belonging to the genus Streptomyces and by recovering said substances from the culture material. The new antibiotic substances possess...
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3992552 |
Antibiotic substance B-41, their production and their use as insecticides and acaricides
New antibiotic substances are obtained by culturing a strain belonging to the genus Streptomyces and by recovering said substances from the culture material. The new antibiotic possess insecticidal...
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3987189 |
Anti-inflammatory composition and method containing cyclic 2-furfural-acetals
Anti-inflammatory cyclic 2-furfural-acetals of the formula ##SPC1## In which X is hydrogen, a lower alkyl preferably having 1 to 4 carbon atoms, or nitro, Z is an alkylene of the formula --CR 1 ...
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3965275 |
Composition and method
A process, and the composition used therein, for estrogenic therapy which comprises administering daily to the patient from about 0.2 to 2000 milligrams of a compound having the formula: ##EQU1##...
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3965274 |
Method of preventing pregnancy with lactone derivatives
A method for inhibiting pregnancy in female mammals which comprises administering an effective amount of a compound having the formulae: ##SPC1## The compound is administered for at least one full...
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3954990 |
Bactericidal and fungicidal cyclic dimedone derivatives of dialdehydes
A novel class of cyclic dimedone derivatives of dialdehydes are useful as antibacterial agents and fungicides. Their high activity and low toxicity make them candidates for replacements for...
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3812262 |
SUBSTITUTED PROPIOLOPHENONES USED AS PLANT FUNGICIDES
Compounds represented by the formula ##SPC1## Wherein one of R 1 and R 2 represents a member selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or...
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