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7618949 |
Drug-eluting stents coated with P2Y12 receptor antagonist compound
The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
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7615539 |
Nucleic acid-lipophilic conjugates
The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic...
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7612047 |
Degradation-resistant mononucleoside phosphate compounds
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7608600 |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention...
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7608597 |
Methods and compositions for treating hepatitis C virus
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
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7605143 |
2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity
The invention provides compounds having the following general formula (I):
wherein X, R 1 , R 2 , R 7 and Z are as described herein.
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7605137 |
Combination therapy comprising cloretazine
This invention provides a method for treating tumor in a subject comprising administering to the subject an effective amount of: (1) VNP40101M, or its equivalent; and (2) a nucleoside, or a...
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7601701 |
Compounds for the treatment of tobacco dependence and withdrawal
The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or...
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7595305 |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an...
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7592326 |
Method for stimulating the immune, inflammatory or neuroprotective response
Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune...
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7589075 |
Use of an adenosine A3 receptor agonist for inhibition of viral replication
The present invention concerns the use of an active ingredient selected from the group consisting of agonists of the adenosine receptor system, for inhibiting viral replication in cells. In...
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7582616 |
Nucleoside transport inhibitors
Compounds or compositions that are inhibitors and/or ligands of nucleoside transporters; and methods of treating cancer, heart disease and stroke, as well as AIDS and other infectious diseases.
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7579331 |
Method of improved diuresis in individuals with impaired renal function
Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic....
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7576069 |
2-polycyclic propynyl adenosine analogs having A2A agonist activity
The invention provides compounds having the following general formula (I):
wherein X, R 1 , R 2 , R 7 and Z are as described herein.
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7576068 |
Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus
This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention...
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7569555 |
Method for stimulating the immune, inflammatory or neuroprotective response
Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune...
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7566703 |
Semi-soft C-class immunostimulatory oligonucleotides
The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for...
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7566702 |
Immunostimulatory oligonucleotide multimers
The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is...
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7560544 |
3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The...
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7557093 |
Composition for promoting collagen production
The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the...
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7557092 |
Purinergic modulation of smell
Disclosed are compositions and methods for modulating odor sensitivity, as well as screening methods for detecting compounds that modulate odor sensitivity.
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7553823 |
C-pyrazole A2A receptor agonists
2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for...
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7550442 |
Nucleoside analog inhibitors of reverse transcriptase
Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase:
R 4 is a nucleoside with Q substituting a 3′ hydroxyl group, and...
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7521432 |
Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
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7517862 |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods...
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7514417 |
A1 adenosine receptor agonists
Disclosed are novel compounds that are partial and full A 1 adenosine receptor agonists having the structure of Formula I:
which are useful for treating various disease states, in particular...
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7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
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7504243 |
Methods for the production of biliverdin
The present invention relates to compositions and methods for the production of biliverdin. In particular, the invention concerns methods for producing biliverdin in yeast, especially Candida...
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7470784 |
Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin
-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose;...
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7468357 |
Nucleosides with anti-hepatitis B virus activity
A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally...
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7462604 |
Hair growth promotor composition
A hair growth promotor which is an ethanol or aqueous ethanol preparation comprising, as active ingredients for a hair growth promotor, (A) at least one compound selected from fatty acids having a...
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7452870 |
Drug-eluting stents coated with P2Y12 receptor antagonist compound
The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
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7435724 |
Degradation-resistant mononucleoside phosphate compounds
The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
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7432272 |
Antiviral analogs
The application relates to 4′-substituted nucleoside derivatives of Formula I:
wherein B and R 1 have any of the values described in the application, as well as to compositions comprising...
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7429571 |
Therapeutic furopyrimidines and thienopyrimidines
The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are...
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7429569 |
Compositions and methods for the regulation of homocysteine levels within the body
Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that...
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7425546 |
Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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7423144 |
Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's...
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7399754 |
N2-quinoline or isoquinoline substituted purine derivatives
Novel compound having the following formula:
wherein W represents a hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or an optionally substituted C...
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7396825 |
Agonists of A2A adenosine receptors for treatment of diabetic nephropathy
The present invention provides a therapeutic method for treating diabetic kidney disease, e.g., diabetic nephropathy that includes the administration of an effective amount of an A 2A adenosine...
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7390782 |
Methods and products related to metabolic interactions in disease
The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The...
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7381713 |
Treatment of cancer by reduction of intracellular energy and pyrimidines
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at...
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7378401 |
Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
The present invention is directed to the systemic administration of Fosfluridine Tidoxil, (5-fluorouridine)-5′-phosphoric acid (3-dodecylmercapto-2-decyloxy)propylester or a salt thereof, for the...
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7374783 |
Powders coated with specific lipoamino acid composition and cosmetics containing the same
There is provided a coated powder having a high skin care effect and a high anti-aging effect. The powder which can be used in cosmetics is coated with a mixture (lipoamino acid composition)...
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7371737 |
2-substituted-6-trifluoromethyl purine derivatives with adenosine-A3 antagonistic activity
The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A 3 receptor antagonists, to methods for the...
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7368437 |
Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents
Methods and compounds for inhibiting the enzymes adenosine monophosphate deaminase or adenoside deaminase are provided. Such methods and compounds are useful in agriculture, horticulture and/or...
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7358235 |
Analogs of nitrobenzylthioinosine
Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these...
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7357930 |
Methods and formulations for targeting infectious agents bearing host cell proteins
A formulation is disclosed for the treatment of diseases caused by an infectious agent which acquires host membranes protein during its life cycle. The formulation is a targeting pharmaceutical...
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7354907 |
Short immunomodulatory oligonucleotides
The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The...
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7354906 |
Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human
The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated...
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