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5439883 |
Antihypoxic formulation
The invention relates to cardiology, and provides an antihypoxic formulation, Energostim, including cytochrome C, nicotinamide adenine dinucleotide and inosine. Energostim provides a complete...
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5430026 |
2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic derivatives,pharmaceutical compositions, and synthetic precursors
The invention provides certain 2-Deoxy-2,2-Difluoro (4-Substituted) Pyrimidine Nucleosides that are effective as anti-cancer agents and in treating viral infections.
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5424295 |
9-β-D-arabinofuranasyl-2-amino-6-methaoxy-9H-purine
The compound 9-B-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine along with its 5'-acetyl and 5'-(4-methoxy-4-oxobutyryl derivatives are disclosed as inhibitors of Varicella Zoster virus (VZV).
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5422343 |
Prophylactic and therapeutic composition for MRSA infection
The invention provides an anti-MRSA prophylactic/therapeutic composition containing as an active ingredient at least one nucleic acid component selected from among inosine, guanosine...
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5420116 |
Pharmaceutical compositions for the treatment of disorders of the respiratory tract
Methods for treating disorders of the upper and lower airways, which disorders involve dehydration of the respiratory epithelium and hyperadhesion of mucus, using adenosine 5'-triphosphate disodium...
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5420115 |
Method for the treatment of protoza infections with 2.sup.1 -deoxy-2.sup.1 -fluoropurine nucleosides
A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine...
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5414000 |
Antiviral pyrinyl substituted tetrahydropyrans
Compounds of the formula ##STR1## wherein R 1 is a substituted purinyl group including pharmaceutically acceptable salts are useful as antiviral agents.
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5399554 |
Readily soluble 2',3'-dideoxyinosine compositions
A readily soluble 2',3'-dideoxyinosine composition is prepared by combining 80 to 1 parts by weight of a basic amino acid and 20 to 99 parts by weight of 2',3'-dideoxyinosine. The greater solution...
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5378693 |
2'-halomethylidene cytidine, uridine and guanosine compounds and their pharmaceutical compositions
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment...
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5376642 |
Treatment of retroviral induced dementia by administration of 2',3'-dideoxyinosine
A preferred method and dosages for treatment of retrovirus-induced dementia by the administration of 2',3'-dideoxyinosine(ddI) is disclosed.
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5374625 |
Adenine and guanine derivatives for the treatment of hepatitis virus infections
A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity: ##STR1## wherein B...
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5366960 |
Method of treating cerebral and cardiovascular disorders employing [R]3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz 0-[4,5-d][1,3]diazepin-8-ol
The present invention discloses the use of [R]-3-(2-deoxy-β-D-erythropentofuranosyl)-3,6,7,8-tetrahydr
oimidazo-[ 4,5-d][1,3]diazepin-8-ol, also commonly known as pentostatin, or a...
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5352669 |
O.sup.6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O.sup.6 -alkylguanine-DNA alkyltransferase depleting activity
O 6 -Benzylated guanine guanosine and 2'-deoxyguanosine compounds of the formula ##STR1## wherein Z is hydrogen, ##STR2## and R is a benzyl group or a substituted benzyl group, cause a depletion...
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5317013 |
Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative...
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5310731 |
N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
Compounds of the formula ##STR1## are disclosed, wherein R 1 , represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl,...
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5292725 |
Administering particular compounds against various parasites, mycoplasmas, other indications and other infections
One or more compounds are administered against one or more kinds of parasites and/or one or more diseases caused by such parasites, against one or more kind of Mycoplasma and/or one or more...
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5276020 |
Anti-virals
Anti-virals wherein a linoleyl, gamma-linolenyl or other unsaturated long chain fatty acyl group is borne directly on a hydroxy or amino group of the sugar/sugar analogue or heterocyclic moiety of...
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5273886 |
Determination of isoaspartate in proteins
The invention relates to methods and means for quantitative determination of the isoaspartyl content of polypeptides via selective methylation of their fragments, catalyzed by a protein...
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5272152 |
Purinyl and pyrimidinyl tetrahydrofurans
Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
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5270304 |
Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain
The present invention concerns a therapeutic-prophylactic agent for ischemic diseases of the heart or brain, comprising as an active ingredient a 2-alkynyladenosine represented by the following...
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5254539 |
Method of treating HIV with 2',3'-dideoxyinosine
A method for tearing retroviral infections including acquired immune deficiency syndrome (AIDS) with 2',3'-dideoxyinosine or 2',3'-dideoxyadenosine is disclosed. This antiviral effect is...
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5246708 |
Methods for promoting wound healing with deoxyribonucleosides
Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine,...
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5231174 |
2'isodideoxy-β-D-nucleosides as stable antiviral agents
The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'β-D-nucleosides and their derivatives where the base moiety has β-stereochemistry but is transposed from the normal...
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5223263 |
Liponucleotide-containing liposomes
Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral...
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5200400 |
Method for inhibiting allograft rejection using photoactivatable nucleotides or nucleosides
Method for inhibiting acute rejection of a transplanted organ or tissue by a recipient mammal that includes the steps of administering to the mammal a compound which causes selective sensitization...
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5192749 |
4'-substituted nucleosides
Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where...
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5187162 |
Methods of treating neurodegenerative conditions
Methods of preventing neural tissue damage caused by excitotoxicity due to increased release of excitatory amino acids by increasing extracellular concentrations of adenosine in and around the...
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5180714 |
Adenosine compounds for the treatment of diseases caused by parasitic protozoa
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5166141 |
Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
An immune response-enhancing guanosine analog derivative having a structure that conforms to the formula ##STR1## wherein Z is oxygen (O) or sulfur (S); X is oxygen (O), sulfur (S) selenium (Se) or...
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5166140 |
Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
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5164376 |
Method for treating retroviral infections with aryl-(2-pyrryl) keytone compound
A method for treating viral infections in a patient with aryl-(2-pyrryl) ketone compound and compositions.
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5153318 |
3'-Azido nucleoside compound
The present invention relates to 3'-azido purine nucleosides and their use in medical therapy, particularly for the treatment of human immunodeficiency virus and hepatitis B virus infections, to...
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5130302 |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
A novel class of pharmaceutically active boronated nucleosides are provided. The nucleosides are boronated at a ring nitrogen of the purine or pyrimidine or analogues thereof. Also provided are...
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5126347 |
Isomeric dideoxynuclesides
Isomeric derivatives of 2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine wherein the adenine or guanine base is attached to the 1' position of the iso-dideoxysugar residue by the 9-N position, the...
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5122517 |
Antiviral combination comprising nucleoside analogs
Antiviral and antitumor compositions are disclosed comprising a mixture of AZT, ribavirin, d4T or CS-87 with a compound of general formula: ##STR1## wherein Z is H, OH or NH 2 , Y is CH, and X is...
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5114931 |
Injectable therapeutic compositions containing stable S-adenosyl-L-methionine salts
The invention discloses injectable therapeutic compositions containing stable S-adenosyl-L-methionine (SAMe) salts as an active ingredient. Injectable therapeutic compositions which permit large...
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5108993 |
Pharmaceutical composition comprising zidovudine and inosiplex or components thereof for the treatment of aids-related syndromes
The administration of a pharmaceutical mixture consisting of the immunomodulator inosiplex or components thereof (p-acetamidobenzoic acid and inosine), and zidovudine (3'-azio-3'-deoxythymidine,...
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5106837 |
Adenosine derivatives with therapeutic activity
Novel adenine derivatives whose structures are represented by Formula I, are disclosed, as are methods of using those compounds and others of Formula II to treat monocyte-mediated disorders and...
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5102873 |
Adenosine compounds useful in the prevention and treatment of vaccinia virus infections
Substituted 1-(benzyloxy)adenosines and the use of substituted 1-(benzyloxy)adenosines and adenosine-N 1 -oxides in the prevention and treatment of vaccinia virus infections are disclosed.
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5093318 |
Immunostimulating guanosine derivatives and their pharmaceutical compositions
7,8-Disubstituted guanosine nucleoside derivatives are found to be potent immune response enhancing agents in human and animal cells. 7-Substituents are heteroatom-substituted-hydrocarbyl radicals...
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5073546 |
Lipophilic salts of S-adenosyl-L-methionine (SAM) with acylated taurine derivatives
Liposoluble salts of S-adenosyl-L-methionine (SAM) with acyl derivatives of taurine having the formula: SAM n [R--CO--NH--(CH 2 ) 2 --SO - 3 ] n in which R--CO is a member selected from C 12 ...
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5073544 |
Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes
This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said...
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5061793 |
2-deoxy-2',2'-difluoro-inosine and 5'O-derivatives
2'-deoxy-2',2'-difluoro-inosine and 5'-O alkyl derivatives are disclosed as inhibitors of neoplasms.
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5053396 |
Therapeutic composition
A therapeutic composition and a method for the treatment of the acute and/or chronic symptoms associated with the excessive ingestion or inhalation of alcohols, most particularly ethanol in the...
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5053499 |
2',3'-dideoxy purine nucleoside
2', 3'-Dideoxy purine nucleosides represented by following general formulae [I] and/or [II] ##STR1## (wherein X and Y indicate nitrogen atoms or carbon atoms and R 1 , R 2 , R 3 , R 4 and R 5 ...
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5051425 |
Therapeutic composition for combatting AIDS
A therapeutic composition for combatting acquired immune deficiency syndrome (AIDS) comprising: (A) a pharmaceutically effective amount of at least one carcinostatic agent selected from alkylating...
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5043325 |
N-6 substituted adenosine derivatives as cardiac vasodilators
New, N-6 monosubstituted adenosine derivatives are disclosed which have significant cardiac vasodilatory effect. The compounds of the invention include 6-(cyclo-butyl...
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5039667 |
Antiviral therapy for hepatitis B with 2',3'-dideoxypurine nucleosides
A method is disclosed for the treatment of hepadnavirus infection in animals. Animals infected with duck hepatitis B virus may be treated with the 2',3'-dideoxynucleoside of adenine, guanine,...
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5034381 |
2-(substituted amino) adenosines as antihypertensives
Disclosed are 2-substituted adenosine derivatives of the formula ##STR1## in which R represents a substituted amino grouping of the formula ##STR2## as defined herein; pharmaceutically acceptable...
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5032584 |
S-diastereomer of an n.sup.6 -((2-hydroxypropyl)aryl)adenosine and its medicinal uses
A novel S diastereomer of an N 6 -[(2-hydroxypropyl)aryl] adenosine, which diastereomer exhibits fewer CNS side effects than the racemate, but with no decrease in cardiovascular activity. The...
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