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6391859 |
&lsqb 5-Carboxamido or 5-fluoro&rsqb -&lsqb 2′,3′-unsaturated or 3′-modified&rsqb -pyrimidine nucleosides
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6372723 |
Compositions and methods for preventing restenosis following revascularization procedures
In the present invention, a method is provided which reduces or prevents restenosis following revascularization procedures. It has now been found that selective stimulation of adenosine A 2A ...
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6372725 |
Specific lipid conjugates to nucleoside diphosphates and their use as drugs
The present invention concerns new phospholipid derivatives of nucleosides of the general formula (I) in which R 1 represents a straight-chained or branched, saturated or unsaturated aliphatic...
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6358915 |
Methods for inhibiting metastasis
The invention relates to methods for determining degree of integrin-mediated maintenance of cell invasive capacity of tumors, and to methods and compositions for inhibiting or preventing metastasis...
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6358934 |
Anti-retroviral activity of 2′,3′-dideoxy-3′-fluoronucleosides
Use of a compound of the formula wherein Base is thymine, Cytosine, adenine or guanine, or a physiologically acceptable salt thereof, for therapeutic or prophylactic control or treatment of...
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6355623 |
Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such...
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6355681 |
Glycine substitutes and precursors for treating a psychosis
Process for treating psychosis such as schizophrenia using a glycine substitute or a precursor thereof to potentiate NMDA receptormediated neurotransmission.
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6342484 |
Method and compositions for promotion of wound treatment
The present invention comprises compositions and preparations for the promotion of wound healing in an animal. Methods for preparing the compositions as well as methods for using the compositions...
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6339073 |
Uses of nicotinamide adenine dinucleotide and its derivatives for treatment of malignant and infectious diseases
This invention provides a method of killing tumor cells or microorganisms which comprises contacting the tumor cells or the microorganisms with an amount of nicotinamide adenine dinucleotide (NAD)...
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6333315 |
4'-C-ethynyl purine nucleoside compounds
The invention provides 4'-C-ethynyl purine nucleosides represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of purine and derivatives thereof; X...
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6331528 |
Method for treatment in gene therapy and use of guanine derivative therefor
The present invention relates to a method for inhibiting cell growth whereby a thymidine kinase gene is introduced and expressed in a cell followed by administering a...
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6326359 |
Adenosine A2A receptor agonists as antiinflammatory agents
The present invention provides compounds of formula (I): ##STR1## and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions...
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6309632 |
Methods for treating HIV-infected patients by administering GM-CSF
Provided are methods for reducing the HIV viral load in HIV-infected patients by administering human GM-CSF. The GM-CSF is administered in conjunction with at least two nucleoside reverse...
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6310039 |
Antineoplastic conjugates of transferrin, albumin and polyethylene glycol
Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at...
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6303618 |
Cyclin dependent kinase inhibiting purine derivatives
Method of treating a tumour or other cell proliferation disorder which comprises administering an effective amount of a purine compound which inhibits cyclic dependent kinase activity. Novel purine...
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6300539 |
Model for chronic cerebral inflammation by intracerebral injection of double stranded RNA
A method of producing a non-human mammalian model of chronic cerebral inflammation is disclosed. The method comprises introducing into the mammal's brain a polynucleotide that does not encode...
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6271212 |
Prodrug azide compositions and compounds
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
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6255291 |
Composition and method for treating cancer and immunological disorders resulting in chronic conditions
A composition containing alph-alanine, adenosine compound and a glucan. Methods for treating cancer and immunological disorders with said composition.
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6251874 |
Method of inhibiting human immunodeficiency virus using hydroxurea and a reverse transcriptase inhibitor in vivo
A method for treating HIV infection in human beings comprising the step of measuring viremia, and if viremia is less than 50,000-100,00 copies per milliliter, administering a combination of...
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6242429 |
Arabinosyladenine derivatives
Antiviral Ara-A derivatives having resistance to metabolism by adenosinedeaminase (ADA) are 2-substituted arabinosyladenine derivatives represented by the formula (I) and pharmaceutically...
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6242428 |
Nucleoside analogs and uses in treating Plasmodium falciparum infection
The invention relates to novel nucleosides and nucleoside dimers containing an L-sugar in at least one of the nucleosides, and their pharmaceutical compositions.
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6232300 |
Treatment of HIV by administration of β-D-2', 3'-didehydro-2',3'-dideoxy-5-fluorocytidine (D4FC)
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6214807 |
C-pyrazole 2A A receptor agonists
2-adenosine C-pyrazole compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for...
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6207650 |
Antiviral, highly water soluble, stable, crystalline salts of 2', 3'-dideoxyinosine, 2', 3'-dideoxy-2', 3'-didehydrothymidine and 2', 3'-dideoxy-2'-fluoroinosine
Provided are very highly water soluble, stable, crystalline salts of 2',3'-dideoxy-2',3'-didehydrothymidine ("d4T"), 2',3'-dideoxyinosine ("ddI"), and 2',3'-dideoxy-2'-fluoroinosine ("F-ddI"). Such...
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6194390 |
Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular...
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6194391 |
3'-azido-2',3'-dideoxyuridine administration to treat HIV and related test protocol
It has been discovered that 3'-azido-2',3'-dideoxyuridine (CS-87) induces a transient mutation in HIV-1 at the 70 th codon (K to R, i.e., lysine to arginine) of the reverse transcriptase region of...
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6194395 |
Cyclodextrin cladribine formulations
There is provided by the present invention liquid injectable and oral solid pharmaceutical dosage forms containing a mixture of cladribine (2-chloro-2'-deoxyadenosine; 2-CdA) and cyclodextrin.
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RE37045 |
N-6 substituted-5'-(N-substituted carboxamide)adenosines as cardiac vasodilator and antihypertensive agents
Compounds of the formula ##STR1## are disclosed, wherein R 1 , represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl,...
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6174873 |
Oral administration of adenosine analogs
Disclosed are compositions including an adenosine analog, wherein the composition comprises a dosage form suitable for oral (co)administration. Also disclosed are compositions including adenosine...
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6156723 |
Compositions comprising inhibitors of estrogen response
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
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6153594 |
5'-O-acylated antiviral nucleosides
A monoester compound of formula I: Nu--O--Fa wherein O is oxygen, Nu is a nucleoside analog, Fa is an acyl group of a mono-unsaturated C18 or C20 omega-9 fatty acid, which fatty acid is...
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6147056 |
Use of locally applied DNA fragments
Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or...
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6130206 |
Treating viral infections associated with chronic fatigue with dsRNA
Virus infections promoting Chronic Fatigue can be diagnosed by assessing the 2'-5'A/RNase L pathway, including measurement of 2'-5'A oligonucleotide levels in the patient's circulating peripheral...
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6117849 |
S-(+)-adenosylmethionine and 3'-azido-2', 3'-dideoxy-nucleoside complexes as potent inhibitors of HIV-replication
Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of...
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6103701 |
Method for enhancing hematopoiesis with acyl deoxyribonucleosides
The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced...
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6103702 |
Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome
Methods of treating various-inflammatory conditions, including systemic inflammatory response syndrome (SIRS), septic shock and burns, conditions which may be ameliorated by increased local...
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6096724 |
Pyrimidine derivatives and guanine derivatives, and their use in treating tumor cells
The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring,...
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6093702 |
Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus...
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6068851 |
Formulation for use in the prevention of pathogen induced diseases including HIV and HSV
This invention relates to formulations comprising film-forming components capable of forming per se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly...
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6063400 |
Targeted liposomal constructs for diagnostic and therapeutic uses
This invention provides a liposomal construct for delivering a diagnostic or therapeutic agent to a mammal comprising a liposomal carrier, a diagnostic or therapeutic agent entrapped within or...
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6060459 |
Enhancing blood cell count with oxypurine nucleosides
The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The...
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6054442 |
Methods and compositions for modulation and inhibition of telomerase in vitro
It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
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6054441 |
Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The...
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6048543 |
Amino acid compositions and use thereof in clinical nutrition
A method for treating a human having elevated tumor necrosis factor levels by administrating an effective amount of one of the amino acids glycine, alanine, or serine.
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6043228 |
O.sup.6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells
O 6 -hetarylalkyl- or naphthylalkylguanine derivatives of the formula ##STR1## wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR', wherein X is O or S, R" and R"' are alkyl, or substituted...
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6027936 |
Carbon monoxide dependent guanyly cyclase modifiers and methods of use
Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring...
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6025343 |
Lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) ##STR1## wherein R 1 represents an optionally substituted alkyl chain...
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6015796 |
Method for treating AIDS
The present invention relates to a method for treating AIDS, which comprises administering to an HIV-infected patient (a) a composition containing as the primary component a polysaccharide derived...
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RE36494 |
2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
Compounds are disclosed having the formulae: ##STR1## wherein R' is hydrogen, lower alkyl or lower alkoxy; r is 0 or 1 and p is zero to four; and wherein R 1 is selected from the group,...
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6001817 |
Pharmaceutical composition comprised of cisplatin, and processes for making and using same
A pharmaceutical composition, comprising cisplatin, a special carrier and, optionally, customary pharmaceutical excipients, is disclosed. The preparation of this pharmaceutical composition is also...
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