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6753322 |
2-aminocarbonyl-9H-purine derivatives
The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the...
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6723737 |
Methods, pharmaceutical and therapeutic compostions for administering adenosine
The invention discloses methods for the chronic administration of adenosine, which contrary to the acute delivery of the drug by injection or infusion, acts in desensitizing adenosine receptors...
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6709679 |
Antineoplastic conjugates of transferin, albumin and polyethylene glycol
Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at...
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6703376 |
Use of uridine triphosphates and related compounds for the prevention and treatment of pneumonia in immobilized patients
A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises...
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6689759 |
Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6689760 |
Anti-mycobacterial compositions
This invention provides compositions of matter, pharmaceutical compounds, methods of synthesizing such compounds and methods for using such compounds to treat animals infected with a pathogenic...
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6683061 |
Enzyme catalyzed therapeutic activation
This invention provides novel substrate compounds that selectively inhibit the proliferation of pathological cells, for example, pathological calls that endogenously overexpress a target enzyme...
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6680303 |
3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
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6680292 |
Pharmaceutical composition comprising ribavirin and growth factors and methods of use
The present invention is directed to compositions comprising 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such...
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6677345 |
Cyclin dependent kinase inhibitors
A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment of...
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6677310 |
Ring-expanded nucleosides and nucleotides
The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded (“fat”) heterocyclic ring, in place of purine, and an unmodified or modified...
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RE38352 |
Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy....
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6663859 |
Compositions for enhancing the immune response
D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration...
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6660719 |
Inhibiting T-Cell proliferation
T-cell inhibition proliferation in a mammalian host by administering effective amounts of 2′-deoxyguanosine and/or prodrugs thereof; and certain PNP inhibitors.
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6660721 |
Anti-HCV nucleoside derivatives
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known...
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6656497 |
Liposomal vector for active-principle
The invention concerns liposome vectors, in powder form, of active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and...
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6642209 |
Use of adenosine compounds to alleviate or normalize pathologically hyperexcited sensory nerve function in a human patient
A method of inducing anesthesia, sedation, analgesia, hypothermia, and reduced stress by administering an effective amount of an adenosine compound to a mammal. It also provides a method for...
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6624203 |
Nucleic acid bases used in ophthalmic solutions
An ophthalmic solutions that are broad ranged and effective in low concentrations relative to state of the art systems. In particular it has been found that ophthalmic solutions comprising 0.00001...
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6620796 |
Combinatorial library synthesis and pharmaceutically active compounds produced thereby
The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications,...
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6596700 |
Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described...
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6593306 |
Methods for modulation and inhibition of telomerase
It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as...
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6593307 |
Cyclic-ADP-ribose analogs
The present invention provides a compound of formula I: wherein A, D, R 1 , and R 2 are as defined in the specification; or a salt or a detectably labeled derivative thereof. The invention also...
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6576636 |
Method of treating a liver disorder with fatty acid-antiviral agent conjugates
The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.
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6569837 |
β-L-2′-deoxy pyrimidine nucleosides for the treatment of hepatitis B
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
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6562801 |
PpGpp and pppGpp as immunomodulatory agents
The present invention relates generally to the fields of immunopreventive therapy and vaccine development. More particularly, it concerns compositions and methods of use of the bacterial...
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RE38090 |
3′-substituted nucleoside derivative
The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents...
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6551612 |
Methods for modulating the axonal outgrowth of central nervous system neurons
Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g.,...
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6548486 |
Fatty acid esters of nucleoside analogs
New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The...
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6537974 |
Method of treating arrhythmias
A method for treating arrhythmia in mammals is provided comprising administering a low dose of an adenosine receptor agonist of the Formula I: wherein R 1 is an optionally substituted...
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6534486 |
2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives
A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a...
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6528042 |
Compositions of flavonoids for use as cytoprotectants and methods of making and using them
Non-naturally-occurring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. These compositions comprise a flavonoid or derivative thereof and...
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6528494 |
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
There are provided according to the invention novel compounds of formula I wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations...
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6511696 |
Infant formula with free amino acids and nucleotides
A fat-rich powder provides the complete nutritional needs of an at-risk infant no more than one year old, who has acquired a milk allergy, such as cow's milk allergy (“CMA”), and/or an allergy...
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6506736 |
Method for obtaining and using a combination of a purine nucleotide and nitrogen monoxide donor for treating sexual dysfunction
A method for treating a human being having or suspected of having sexual dysfunction or a disorder of physiological and/or anatomical response to sexual stimulation, said dysfunction or disorder...
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6498149 |
Natural antitumor or antiviral substances and use of the same
The present invention provides substances having an efficacy against tumors and viruses on which the conventional anti-tumor agents and anti-virus agents exhibit only insufficient effects, and...
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6495521 |
Combination therapy method for treating chronic hepatitis B
The present invention is aimed at augmenting the success rate of using thymosin in treatment of chronic hepatitis B, by employing a combination therapy using thymosin with antiviral agents which...
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6495528 |
2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2...
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6489098 |
Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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6479466 |
Compositions for treating viral infections, and methods therefor
Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a...
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6475491 |
Treatment of HIV and other viral infections using combinatorial therapy
Novel antiviral combinations for the treatment or prevention of viral infections, in particular, HIV, are disclosed. This new antiviral therapy employs either DP-178 or DP-107, viral fusion...
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6458772 |
Prodrugs
Compounds of the formula I or corresponding monohydroxynucleoside derivatives wherein: R 1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon; a C 4 -C 22 ...
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6455507 |
Benzimidazole derivatives
Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of...
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6455508 |
Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
Novel heterocyclic aromatic compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may...
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6448236 |
Purine derivatives
The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation...
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6440946 |
Multiple-agents-binding compound, production and use thereof
The present invention is to provide a multiple-agents-binding compound comprising a compound having anti-HIV activity and having no affinity for cell surface protein bound together with a same or...
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6440469 |
Plant protein for nutritional products and method of making same
The present invention relates generally to a method of producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese or nucleotides. More...
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6440980 |
Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically...
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6423692 |
Method of enhancing the effectiveness of DCK phosphorylated molecules
A method of increasing the effectiveness of molecules that can be phosphorylated by dCK is described. This method involves transducing cells with the gene for deoxycytidine kinase which can...
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6403566 |
Nucleosides having bicyclic sugar moiety
Conformationally restricted 2′, 4′—bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or...
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6399654 |
Biflavanoids and derivatives thereof as antiviral agents
Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are...
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