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9040492 Double-stranded lipid-modified RNA having high RNA interference effect  
An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference...
9040234 Oligonucleotide analogs as therapeutic agents  
The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the...
9040078 Use of lipid conjugates in the treatment of diseases of the nervous system  
The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple...
9034837 Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon  
The present invention provides compositions and methods of treatment of HCV infected subjects that are not sensitive to interferon treatment. Further, compositions and methods are provided for...
9034836 Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders  
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is...
9029142 Recombinant vectors and hosts comprising human glucokinase encoding gene  
Gene encoding human glucokinase mutant is provided. The gene has the nucleotide sequence chosen from the nucleotide sequence listed as SEQ ID NO:2 and the nucleotide sequence wherein the ORF...
9029336 Xenobiotic related induction of gene expression  
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid...
9029135 Kanamycin antisense nucleic acid for the treatment of cancer  
The invention relates to a nucleic acid comprising a sequence complementary to a fragment of the sequence coding for the kanamycin resistance protein. This nucleic acid is useful as a DNA vaccine...
9023819 Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification  
Disclosed herein is a method for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, the method...
9017661 Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes  
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo....
9018182 Tumor specific promoter and oncolytic virus vector comprising the same  
Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows...
9017696 Adenovirus vectors  
An adenoviral vector comprising a promoter further comprising a fragment of the 5′ untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or...
9011855 Weed control in joints of concrete block and other paving stone  
The present weed reducing material reduces the necessary weed control work by making joint filling sand a hostile substrate for plant and fungus growth by using an environmentally acceptable slow...
9012424 Nanogels  
The present invention relates to a polymer according to Formulas (1) or (2): The present invention further relates to nanogels and nanoparticles made of a polymer according to general Formulas (1)...
9012140 Target-dependent nucleic acid adapter  
In accordance with the present invention, there is provided a nucleic acid target-dependent adapter linked to a nucleic acid sequence. The adapter comprises linked together a biosensor having a...
9012225 Lipophilic polynucleotide conjugates  
Disclosed are lipophilic polynucleotide conjugates including polynucleotide-cholesterol conjugates and methods of delivering therapeutic polynucleotides to a mammalian cell or patient in need of...
9012417 Topical administration of NF-kappaB decoy to treat atopic dermatitis  
A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least...
9012422 Method of treating acute myelogenous leukemia  
The present invention relates to active compounds for treating acute myelogenous leukemia (AML) in a subject in need thereof and methods of treating AML carried out by administering the subject an...
9006190 Compositions and methods for cancer diagnosis and therapy  
The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate...
9006193 Polymeric carrier  
Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
9006203 Method of reducing inflammatory infiltration in subjects with inflammatory lung disease  
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for reducing neutrophil infiltration in subjects with inflammatory lung disease-by...
8999948 Vectors and sequences for the treatment of diseases  
The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
8999380 Modified polynucleotides for the production of biologics and proteins associated with human disease  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
8999947 Nucleic acid functionalized nanoparticles for therapeutic applications  
Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
8999946 Chimeric adenoviral vectors  
The present invention provides chimeric adenoviral vectors and methods for using the vectors to elicit an immune response to an antigen of interest.
8999927 Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof  
Described herein is the identification of primate-specific glial cell line-derived neurotrophic factor opposite strand (GDNFOS) transcripts and encoded peptides. In particular embodiments,...
8999949 Induced activation in dendritic cells  
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
8993316 Methods and compositions for gene therapy and GHRH therapy  
A composition and method comprising an anti-adjuvant such as DOI (an anti-inflammatory) together with any gene therapy plasmid is disclosed. A method for GHRH production in-vivo using a set of...
8993327 Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures  
Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes....
8993531 PKD ligands and polynucleotides encoding PKD ligands  
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The...
8993528 Oligomeric compounds comprising tricyclic nucelosides and methods for their use  
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided...
8987221 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9  
The invention provides the use of immune regulatory oligonucleotides (IRO) as antagonist of TLRs and potentiators of anti-inflammatory agents that inhibit TNF for the prevention and treatment of...
8987211 Therapeutic peptides and use thereof against huntington's disease  
Fusion proteins that contain the fusion of (i) a peptide of less than 100 amino acids comprising a first amino acid sequence comprising AASSG (SEQ ID NO: 1) and a second amino acid sequence...
8980864 Compositions and methods of altering cholesterol levels  
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
8980851 Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway  
Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic...
8980859 Aegyptin and uses thereof  
The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel...
8980295 Multifunctional in situ polymerized network via thiol-ene and thiol-maleimide chemistry  
Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second...
8980826 Method of treating chronic obstructive pulmonary disease  
The present invention relates to a method of promoting bronchodilation by administration of streptolysin O to a subject in need thereof.
8980862 Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD)  
Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably...
8975044 Polynucleotides encoding for frizzled-binding agents and uses thereof  
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as...
8975079 Reducible polymers for nonviral gene delivery  
Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The...
8975293 Epigenetic co-repressors of the gamma-globin gene and methods of using same  
This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This...
8969077 Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord  
The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding...
8962590 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer....
8961994 DNA constructs eliciting immune response against flavivirus and effective adjuvants  
Aspects of the present invention relate to isolated nucleic acids that encode a consensus DIII domain of protein E and vaccines made using same, and also methods for using the aforementioned to...
8962589 Cell line, system and method for optical control of secondary messengers  
A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence...
8962591 Compositions and methods for treating cancer  
This invention generally relates to compositions and methods for targeted delivery of chemotherapeutic agents to cancerous and pre-cancerous cells, thereby treating a cancer in a subject.
8962579 Methods and compositions for inhibition of immune responses and autoimmunity  
The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to...
8962614 ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors  
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog...
8962587 Gene delivery of OCT4 and SirT1 and pharmaceutical compositions thereof  
The present invention provides a method for decreasing the level of methylation of Oct4 promoter in a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and...