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8785414 Differentially expressed microRNAs as biomarkers for the diagnosis and treatment of Sjögren's syndrome  
The identification of differentially expressed microRNAs in patients with Sjögren's syndrome is disclosed herein. Provided is a method of diagnosing a subject as having Sjögren's syndrome by m...
8785412 Method for inducing cancer cell apoptosis or inhibiting the cancer cell migration  
The present invention is related to a method for inducing the cancer cell apoptosis or inhibiting the cancer cell migration by inhibiting the expression of ribose-5-phosphate isomerase A.
8785407 Antisense antiviral agent and method for treating ssRNA viral infection  
The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment...
8778900 Modulation of eIF4E-BP1 expression  
Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of...
8778904 Methods and compositions for treating diseases, disorders or injury of the CNS  
The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use...
8779113 Group of nucleic acid fragments for prevention of HIV infection or AIDS and the usage thereof  
The invention provides a group of nucleic acid fragments, shown in the sequence listing, for prevention of HIV infection or AIDS and the usage thereof. In the invention, a series of RNA fragments,...
8778905 USP47 inhibitors and methods to induce apoptosis  
The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates...
8772254 Method and constructs for delivering double stranded RNA to pest organisms  
The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA)...
8772261 Treatment of tumors with genetically engineered herpes virus  
Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
8772260 Methods for inhibiting expression of connective tissue growth factor  
This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of...
8772262 Preventive or therapeutic agent for fibrosis  
Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA. An siRNA having a full length of 30 or fewer nucleotides and targeting a sequence consisting of...
8772257 SDF-1 binding nucleic acids and the use thereof  
The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells.
8772471 Targeted delivery of siRNA  
The present invention provides a method of delivering RNA interference molecules to a cell or a cell in a subject, which comprises contacting the cell with a protein-double stranded RNA complex,...
8772255 Cell transfecting formulations of small interfering RNA related compositions and methods of making and use  
Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and...
8772258 Single walled carbon nanotube/sirna complexes and methods related thereto  
The present invention includes single-walled carbon nanotube compositions for the delivery of bioactive agents and methods of making such single-walled carbon nanotube compositions.
8772259 Aptamer to FGF2 and use thereof  
Provided are an aptamer having an inhibitory activity on FGF2; a complex containing an aptamer having a binding activity or an inhibitory activity on FGF2, and a functional substance (e.g.,...
8765699 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases  
The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical...
8765703 Modification of MYD88 splicing using modified oligonucleotides  
Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
8765931 Double-stranded oligonucleotide compound for down-regulating the expression of CASP2 gene  
The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an...
8765701 Oligomeric compounds and compositions for use in modulation of small non-coding RNAs  
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding...
8765700 Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions  
A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or...
8765708 Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas  
The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs...
8765702 Composition and methods for modulating cell proliferation and cell death  
Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
8765376 Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator  
The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of...
8765709 Methods and compositions involving miRNA and miRNA inhibitor molecules  
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns...
8765707 MicroRNA-140-5p as a tumor suppressor and sensitizing agent for chemotherapy  
The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances...
8765705 Oligonucleotides inhibiting cellular migration  
Oligonucleotides inhibiting cellular migration, and the use of at least one inhibitor of protein expression, which inhibits the expression of TSP1 protein, or a protein, which controls the...
8759314 Methods for treating multiple sclerosis using antisense oligonucleotides  
A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising...
8759104 Cationic lipids  
The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a...
8759313 Treatment of fibrosis using microRNA 19b  
The present invention provides a method for treating or preventing fibrosis comprising administering to a patient in need of such treatment or prevention an amount of microRNA-19b effective to...
8759309 Polynucleotides that stimulate neutrophils  
The polynucleotides of the present invention are complementary to the Initiation Sites of microbes. Invading organisms, sensing the pH and nutrient deprivation of a physiologic environment quickly...
8759306 RNAi for the control of insects and arachnids  
The present invention describes a new non-compound based approach for insect and/or arachnid control. The present inventors have identified for the first time novel targets for RNAi, which can...
8759311 Use of siRNA targetting SIPA1L1 for the reduction of adipogenesis  
The present invention concerns Sipa1l1, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Sipa1l1 activity in preadipocytes and...
8754060 Methods and compositions for inhibition of axonal degeneration by modulation of the DLK/JNK pathway  
Methods of reducing Wallerian degeneration are disclosed. These methods comprise inhibiting expression or activity of a mixed lineage kinase such as a dual leucine-zipper-bearing kinase (DLK),...
8754058 Inhibitors of FAM3B gene, inhibitor compositions, inhibiting methods and applications of inhibitors in preparing pharmaceuticals  
Inhibitors that can inhibit expression of FAM3B gene to reduce the levels of expression products, or can combine the expression products to reduce the activity of promoting lipid synthesis of FAM3B...
8754056 Enhancing vessel lesion homing and repair potential of stem cells  
Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which TGF-β expression and/or activity has been transiently blocked. Other methods ...
8754057 Inhibition of apoptosis-specific eIF-5A(eIF-5A1″) with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics  
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for...
8754201 Therapeutic compositions  
This application relates to therapeutic siRNA agents and methods of making and using the agents.
8748403 Modulation of HSV infection  
Toll-like receptor 2 (TLR2) has been found to mediate certain effects of HSV infection, particularly in neonates. Compounds that decrease TLR2 expression or activity are useful for ameliorating...
8747903 Composition for nucleic acid delivery using metal nanoparticles and preparing method thereof  
The present invention relates to a composition for nucleic acid delivery and a method for preparing the same, more particularly to a composition for nucleic acid delivery having excellent stability...
8748405 Methods and compositions for the treatment of cancer or other diseases  
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods...
8748406 Preventive for adhesion following abdominal surgery  
The present inventors discovered that oligonucleotides which suppress midkine expression and antibodies which suppress midkine activity can be used to prevent post-surgical intraperitoneal adhesions.
8741867 Retinoid-liposomes for treating fibrosis  
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are...
8741864 Gene expression and pain  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
8741865 Treatment of immune disorders with Hom-1 inhibitors  
Disclosed are methods for treating immune disorders using inhibitors of Hom-1. The inhibitors include an RNAi agent containing the sequence of SEQ ID NO: 6.
8742091 Method of promoting nucleic acid transfer  
Means for transferring efficiently a desired nucleic acid into a cell is provided. The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired...
8741861 Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases  
The present invention discloses multiple treatment regimens for vascular-related diseases and disorders. The present invention provides for methods of treating vascular-related disorders based on...
8741868 Pharmaceutical composition including an HIF-2 alpha inhibitor as an active ingredient for preventing or treating arthritis  
The present invention relates to a pharmaceutical composition for preventing or treating arthritis, including, as an active ingredient, a material which inhibits the expression of the...
8741863 Compound and method for treating myotonic dystrophy  
An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a...
8735367 Small molecule-dependent split aptamer ligation  
Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first...