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8466119 |
Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL,...
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8466122 |
Trialkyl cationic lipids and methods of use thereof
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that...
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8466120 |
Oligomeric compounds and compositions for use in modulation of pri-miRNAs
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of pri-miRNAs. In particular, methods and compounds are provided for the modulation of...
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8466117 |
Compositions and methods for modulating angiogenesis
The invention generally features compositions and methods that are useful for modulating angiogenesis.
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8461124 |
Five- and six-membered conformationally locked 2′,4′-carbocyclic ribo-thymidines for the treatment of infections and cancer
Conformationally locked 2′,4′-carbocylic nucleosides with improved thermal and nuclease stability are disclosed. Oligonucleotides incorporating the locked nucleosides, and methods of treating dis...
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8461101 |
Targeting PAX2 for the treatment of breast cancer
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
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8461127 |
p27 and p21 in gene therapies
The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21cip1/waf1 and/or p27, cyclin dependent kinase inhibitors....
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8461126 |
Targeting EN2, PAX2, and/or DEFB1 for treatment of prostate conditions
The present invention relates to methods and compositions for treating a prostate condition in a subject. The method comprises administering to the subject a subject effective amount of a...
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8461125 |
Compositions and methods to treat asthma
The present invention provides compositions and methods for the treatment of asthma. The compositions can be, for example, siRNA directed to CD23. The invention also provides a method of treating...
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8455454 |
miR 204, miR 211, their anti-miRs, and therapeutic uses of same
Embodiments of the invention provide methods of preventing or treating detrimental epithelial cell proliferation, loss of epithelial cell differentiation, age-related macular degeneration and/or...
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8455518 |
Method of treating skin with microRNA modulators
Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast,...
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8455456 |
Compositions and their uses directed to diacylglycerol acyltransferase 1
Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating,...
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8455455 |
Compositions and methods for silencing genes involved in hemorrhagic fever
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target Lassa virus (LASV) or tissue factor (TF) gene...
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8450291 |
RNA antagonist compounds for the modulation of PIK3CA expression
The invention relates to oligomeric compounds (oligomers), which target PIK3CA mRNA in a cell, leading to reduced expression of PIK3CA. Reduction of PIK3CA expression is beneficial for the...
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8450282 |
Anionic polymer, polyion complex and ternary polymer composite using anionic polymer, and pharmaceutical composition
There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without...
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8450292 |
Oligonucleotides or their functional homologues, a composition comprising the same and a method of treating B cell neoplasm
The invention provides nine oligonuleotides with sequences of SEQ ID NO:1-9 or their functional homologues or a composition comprising the same and a method for treating B cell neoplasm by using...
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8445456 |
Use of RNA interference for treating or reducing pain
A use of a nucleic acid molecule mediating RNA interference for treating or reducing pain is disclosed. The nucleic acid molecule has a sequence selected from the group consisting of SEQ ID NO:1,...
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8440636 |
Micro-RNA family that modulates fibrosis and uses thereof
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29...
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8440637 |
Combination treatment for the treatment of hepatitis C virus infection
The present invention relate to the use of a combination of an inhibitor of miR-122 and an inhibitor of VLDL assembly, for the treatment of HCV, hyperlipidemia and hypercholesterolemia.
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8440809 |
RNA antagonists targeting Hsp27
The present invention relates to oligomer compounds (oligomers), which target Hsp27 mRNA in a cell, leading to reduced expression of Hsp27. Reduction of Hsp27 expression is beneficial for the...
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8440878 |
Insulin-like gene in prawns and uses thereof
The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii). The present...
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8440393 |
Pro-angiogenic genes in ovarian tumor endothelial cell isolates
A gene profiling signature for ovarian tumor endothelial cells is disclosed herein. The gene signature can be used to diagnosis or prognosis an ovarian tumor, identify agents to treat an ovarian...
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8431544 |
Compositions for inhibiting gene expression and uses thereof
The inventors have examined the means for providing more efficacious gene expression blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy...
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8431542 |
Micrornas that regulate muscle cell proliferation and differentiation
The presently disclosed subject matter provides methods and compositions for modulating gene expression in myocytes. Also provided are cells comprising the compositions of the presently disclosed...
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8431398 |
Methods for modulating the proliferation and differentiation potential of stem cells and progenitor cells
Modulators of TRIM-NHL proteins and their use for modulating the proliferation and differentiation potential of stem cells and progenitor cells. Inhibitors of TRIM-NHL proteins, e.g. TRIM32, are...
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8431547 |
Synthetic genes and genetic constructs
The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant....
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8431543 |
Chitosan based polymer conjugate and a method for producing the same
The present invention relates to a conjugate of chitosan and polyamine polymer that is useful for transferring a desired gene medicine into cells, and a method for preparing the same. In...
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8426379 |
POT1 alternative splicing variants
The present invention provides methods and compositions for diagnosis and treatment of carcinomas with aberrant expression patterns of POT 1. The invention also provides methods of identifying...
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8426380 |
Inhibition of viral gene expression using small interfering RNA
The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as...
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8426378 |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided...
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8420612 |
Diabetes treatment methods and drug targets therefor
Provided are methods of treating insulin resistance or type II diabetes. Disrupting CAP in the macrophage can alter the inflammatory response associated with impaired insulin action and ultimately...
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8420617 |
Multiantivirus compound, composition and method for treatment of virus diseases
A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a...
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8420613 |
Methods and compositions for reducing amyloid beta levels
The present invention provides methods for reducing the level of amyloid beta protein in a cell or tissue, the methods generally involving contacting the cell or tissue with an agent that reduces...
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8420614 |
Compositions and methods for inhibiting or reversing fibrotic disorders
The present invention provides compositions and methods for inhibiting or reversing fibrotic disorders by administering a Hic-5 antagonist to a mammal in need thereof. The invention also includes...
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8420616 |
MAT II beta subunit RNAi and therapeutic methods using same
The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods and...
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8415319 |
Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
The present invention relates to devices, systems, and methods for improving memory and/or cognitive function by brain delivery of compositions of small interfering RNA or vectors containing the...
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8415315 |
Methods and compositions for inhibiting the proliferation of cancer cells
A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an...
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8415316 |
Method for increasing bone mass
The present invention features methods for promoting the differentiation of osteoblast bone forming cells to a mineralization phenotype and increasing bone mass using inhibitors of Brahma. Subjects...
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8415323 |
MicroRNAs for inhibiting viral replication
The present invention relates to reducing accumulation of viral genomes in a target cell. In particular the present invention provides compositions and methods for combating viral infection through...
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8415313 |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
A method and composition for inducing human dendritic cells to a condition of reduced capacity for antigen-specific activation of T cells, and, in mature dendritic cells, increased production of...
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8415314 |
Methods for treating multiple sclerosis using antisense oligonucleotides
A method for treating a patient suffering from multiple sclerosis, particularly a relapsing form of multiple sclerosis, comprising periodically administering a pharmaceutical composition comprising...
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8410070 |
Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a...
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8410069 |
Oligoribonucleotide inhibitors of Nrf2 and methods of use thereof for treatment of cancer
The invention provides novel double stranded oligoribonucleotides that inhibit the Nrf2 gene. The invention also provides a pharmaceutical composition comprising one or more such...
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8410067 |
Inhibition of versican with siRNA and other molecules
The present invention provides methods of treating disease or condition in a subject in need thereof, comprising administering the subject a versican inhibitor in an amount effective to treat the...
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8410074 |
Modulation of eIF4E expression
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid...
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8410073 |
Methods and compositions for prevention or treatment of RSV infection
Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose...
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8404658 |
RNA interference for the treatment of heart failure
The present invention relates to targeted RNAi for the treatment of heart failure by modulating defective cardiac Ca2+ homeostasis via decreasing expression or activity of phospholamban (PLB) using...
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8404659 |
Pharmaceutical compositions for treatment of MicroRNA related diseases
The present invention provides compositions and methods of treatment of diseases that are sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or viral genomes. In...
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8404657 |
Means and methods for treating or preventing brain tumors based on the nuclear receptor tailless (Tlx)
The present invention relates to the use of an inhibitor of tailless gene expression or tailless protein activity for the preparation of a pharmaceutical composition for treating or preventing the...
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8404656 |
Methods of treatment and prevention of diet-induced obesity and sequelae thereof
Disclosed are methods of treating or preventing diet-induced obesity and/or one or more sequelae thereof in a subject. These methods comprise administering to a subject in need of treatment or at...
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