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8835402 Compound and method for treating myotonic dystrophy  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic d...
8828963 Diagnosis and treatment of chronic lymphocytic leukemia (CLL)  
New markers in the form of miRNA levels in plasma are provided for indicating the presence of CLL in a subject as well as suggesting routes of therapeutic treatment.
8828960 Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds  
The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by...
8828959 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells  
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for...
8828958 Single-stranded antimicrobial oligonucleotides and uses thereof  
The current invention is directed to oligonucleotide sequences isolated from a sequence designated rbl-1 [SEQ ID NO. 19] that either kill or inhibit growth, or prevent the production of...
8828962 SiRNA compositions and methods for potently inhibiting viral infection  
No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique...
8828964 Cancer cell identification marker and cancer cell proliferation inhibitor  
Disclosed is an identification marker which can be utilized for detection of various human cancer cells and whose expression closely relates to malignant alteration of cells, and compositions for...
8828965 MiR-150 for the treatment of blood disorders  
The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor...
8828961 Methods and compositions to protect aquatic invertebrates from disease  
Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is...
8822426 Prevention and treatment of nosema disease in bees  
Compositions and methods for reducing susceptibility and enhancing tolerance to Nosema disease (Nosemosis) using RNA interference technology, and more particularly, prevention and treatment of...
8822427 Methods and compositions to protect aquatic invertebrates from disease  
Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is...
8822425 Dosage of oligonucleotides suitable for the treatment of tumors  
A method for preventing and/or treating a tumor, the method comprising: intravenously administering an antisense oligonucleotide in an amount of between about 400 to about 800 mg/m2/treatment...
8822428 Double-stranded RNA oligonucleotides which inhibit tyrosinase expression  
Novel double-stranded RNA oligonucleotides are useful for decreasing tyrosinase expression, have cosmetic and/or pharmaceutical applications, for example are useful skin depigmenting or...
8822669 miRNA expression vector  
A miRNA expression vector including SEQ ID NO. 11. The vector is capable of improving the fertility of animals by inhibiting the expression of inhibin.
8815825 Methods and compositions for the specific inhibition of beta-catenin by double-stranded RNA  
This invention relates to compounds, compositions, and methods useful for reducing β-catenin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.
8815821 Double-stranded oligonucleotides  
Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer...
8815818 Phagocytic cell delivery of RNAI  
The present invention provides a particulate delivery system for delivering an RNAi construct to phagocytic cells such as macrophages, comprising various configurations of a complex comprising a...
8815823 Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors  
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue...
8815819 Anti-connexin compounds targeted to connexins and methods of use thereof  
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and...
8815822 Means and methods for counteracting, delaying and/or preventing adverse energy metabolism switches in heart disease  
The invention relates to the fields of molecular biology and medicine, more specifically to treatment and prevention of heart disease. The invention provides alternative methods for counteracting,...
8809295 Composition containing inhibitors of the expression or activity of SH3RF2 for preventing or treating cancer  
The present invention relates to a composition comprising an inhibitor of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for preventing or treating cancers. More...
8809289 Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer  
A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an...
8809516 Therapeutic compositions  
This application relates to therapeutic siRNA agents and methods of making and using the agents.
8809291 Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma  
A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other...
8809293 Compositions and methods for inhibiting gene expression of hepatitis B virus  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising...
8809287 Compositions and methods for altering Wnt autocrine signaling  
The present invention relates to compounds and methods for treating cancers in which the autocrine Wnt canonical signaling pathway is activated. In particular, there is provided a method for...
8809517 Method of inhibiting Alu RNA and therapeutic uses thereof  
The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the...
8809294 Method of inhibiting miR-33 using a modified oligonucleotide  
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding...
8809292 Compositions and methods for inhibiting expression of the PCSK9 gene  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which...
8809296 Apoptosis inducer for cancer cell  
The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer...
8802153 System for targeted delivery of therapeutic agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
8802640 Oligonucleotides for RNA interference and biological applications thereof  
The invention relates to compositions comprising double-stranded oligonucleotides of identical or different sequences and/or length, said oligonucleotides having sequences 3′N1N2 . . . Ni-1Ni . . ....
8802648 Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity  
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention pr...
8802639 RNA interference modulators of hedgehog signaling and uses thereof  
The instant application relates to methods and reagents for modulating the Hedgehog signaling pathway using RNA interference technology (RNAi). The application provides potential targets of the...
8802649 Methods and compositions for inhibiting the proliferation of cancer cells  
A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an...
8802644 Lipid formulation  
The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids,...
8802839 Connective tissue growth factor antisense oligonucleotides  
The present invention relates to antisense oligonucleotides that target human CTGF mRNA and inhibit CTGF mRNA expression. Additionally, regions of human CTGF mRNA that are exceptionally sensitive...
8802645 Molecule for treating an inflammatory disorder  
The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to...
8802138 Methods and compositions for improved deliver, expression or activity of RNA interference agents  
The present disclosure provides methods and compositions for enhanced delivery of siRNA or miRNA, into the interior of multilayered tissues, and into the cytoplasm or nucleus of cells of a tissue....
8795734 Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells  
Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes...
8796235 Methods for attenuating dengue virus infection  
The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression...
8796239 Sirna compounds comprising terminal substitutions  
The invention relates to modified siRNA compounds which down-regulate target gene expression, to pharmaceutical compositions comprising such compounds and to methods of treating and/or preventing...
8796238 Short RNA mimetics  
The present invention provides synthetic oligonucleotides that mimic the function of short RNAs such as, for example, microRNAs or short interfering RNAs. In particular, the synthetic...
8795648 Poly(beta malic acid) with pendant Leu-Leu-Leu tripeptide for effective cytoplasmic drug delivery  
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a...
8796240 Cell growth inhibitor and screening method thereof  
An object is to provide a cell growth inhibitor also effective for androgen-independent prostate cancer. The present invention provides a cell growth inhibitor having, as an active ingredient, an...
8791088 Compositions and methods for modulation of LMNA expression  
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of...
8791087 Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of ‘C terminus of HSP70-Interacting Protein’ (CHIP), in particular, by targeting nat...
8791082 Double-stranded and single-stranded RNA molecules with 5′ triphosphates and their use for inducing interferon  
Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects,...
8791083 Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry  
The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3′-endo conformational geometry (3′-endo reg...
8791250 Compositions and methods for inhibiting expression of the HAMP gene  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is...